{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T12:15:40Z","timestamp":1773663340968,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"18","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The collateral sensitivity effect is among the most promising strategies for overcoming multidrug resistance in cancer. In this work, 28 cucurbitane-type triterpenoids (1\u201328), previously isolated from the African medicinal plant Momordica balsamina and its derivatives, were evaluated for their collateral sensitivity effect on three different human cancer entities, gastric (EPG85-257), pancreatic (EPP85-181), and colon (HT-29), each with two different multidrug-resistant variants. One was selected for its resistance to daunorubicin (EPG85-257RDB, EPP85-181RDB, HT-29RDB) and the other was selected for its resistance to mitoxantrone (EPG85-257RNOV, EPP85-181RNOV, HT-29RNOV). On gastric cell lines, the best results were obtained for compounds 3 and 10, which exhibited a collateral sensitivity effect together with high antiproliferative activity. In turn, on colon cancer cell lines, the best multidrug resistance-selective antiproliferative effects were observed for derivatives 11, 13, and 15, which showed collateral sensitivity effects against both resistant variants. Compounds 11 and 3 were also the most selective against the multidrug resistance pancreatic cells lines. Some compounds, such 6, 10, 11 and 15, were previously found to be strong P-glycoprotein modulators, thus highlighting their potential as promising leads for overcoming multidrug resistance in cancer cells.<\/jats:p>","DOI":"10.1055\/a-0651-8141","type":"journal-article","created":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T19:16:18Z","timestamp":1531336578000},"page":"1372-1379","source":"Crossref","is-referenced-by-count":23,"title":["Triterpenoids from Momordica balsamina with a Collateral Sensitivity Effect for Tackling Multidrug Resistance in Cancer Cells"],"prefix":"10.1055","volume":"84","author":[{"given":"C\u00e1tia","family":"Ramalhete","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal"},{"name":"ATL\u00c2NTICA \u2013 Escola Universit\u00e1ria de Ci\u00eancias Empresariais, Sa\u00fade, Tecnologias e Engenharia, Oeiras, Portugal"}]},{"given":"Silva","family":"Mulhovo","sequence":"additional","affiliation":[{"name":"Centro de Estudos Mo\u00e7ambicanos e de Etnoci\u00eancias, Faculty of Natural Sciences and Mathematics, Pedagogical University, Maputo, Mozambique"}]},{"given":"Hermann","family":"Lage","sequence":"additional","affiliation":[{"name":"Institute of Pathology, University Hospital Charit\u00e9, Berlin, Germany"},{"name":"Department of Pathology, Vivantes Clinics, Berlin, Germany"}]},{"given":"Maria-Jos\u00e9","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal"}]}],"member":"194","published-online":{"date-parts":[[2018,7,11]]},"container-title":["Planta Medica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0651-8141.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T19:29:52Z","timestamp":1543433392000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0651-8141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,11]]},"references-count":0,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2018,11,28]]},"published-print":{"date-parts":[[2018,12]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0651-8141","relation":{},"ISSN":["0032-0943","1439-0221"],"issn-type":[{"value":"0032-0943","type":"print"},{"value":"1439-0221","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,11]]}}}