{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T21:10:24Z","timestamp":1719868224625},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite the importance attributed to exercise training in the breast cancer (BC) continuum, the underlying mechanisms modulating tumor behavior are unknown. We evaluated the effects of long-term moderate-exercise in the development of mammary tumors, and studied the microenvironment of infiltrative lesions, the amount of connective tissue, and balance between cellular proliferation\/death.<\/jats:p><jats:p>Fifty Sprague-Dawley rats, randomly assigned into four groups: two control groups (sedentary and exercised) and two models of BC groups (sedentary and exercised) induced by N-methyl-N-nitrosoureia (MNU), were sacrificed after 35 weeks of moderate-exercise, and all perceptible tumors were removed for histological and immunohistochemistry analysis.<\/jats:p><jats:p>The median number of infiltrative-lesions per animal was lower in the MNU exercised animals (p=0.02). More than one histological pattern was identified, and papillary carcinoma was the most frequent in both groups. Within infiltrative-lesions, the number of immunopositive cells per \u03bcm2 of Ki67 was lower in exercised animals (p=0.002). This presents increased cell death per \u03bcm2 (p=0.019). Tumors from sedentary animals had a higher expression of collagen deposition (p=0.027).<\/jats:p><jats:p>Long-term moderate-exercise has beneficial effects in tumor development with a diminished prevalence of malignancy. Within infiltrative-lesions, moderate-exercise improves the balance between cell-proliferation and cell-death with decreased connective tissue that suggests lower tumor aggressiveness.<\/jats:p>","DOI":"10.1055\/a-0660-0198","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T22:40:59Z","timestamp":1533940859000},"page":"885-892","source":"Crossref","is-referenced-by-count":3,"title":["Exercise Training-induced Modulation in Microenvironment of Rat Mammary Neoplasms"],"prefix":"10.1055","volume":"39","author":[{"given":"Ana","family":"Figueira","sequence":"additional","affiliation":[{"name":"CIAFEL, Research Center in Physical Activity, Health and Leisure; Faculty of Sport, University of Porto, Porto, Portugal"},{"name":"Polytechnic Institute of Set\u00fabal, Set\u00fabal, Portugal, Department of Sciences and Technologies\/Sport Sciences, Set\u00fabal, Portugal"}]},{"given":"Mafalda","family":"Figueira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Set\u00fabal Hospital Center"}]},{"given":"Carina","family":"Silva","sequence":"additional","affiliation":[{"name":"CIAFEL, Research Center in Physical Activity, Health and Leisure; Faculty of Sport, University of Porto, Porto, Portugal"}]},{"given":"Ana","family":"Padr\u00e3o","sequence":"additional","affiliation":[{"name":"CIAFEL, Research Center in Physical Activity, Health and Leisure; Faculty of Sport, University of Porto, Porto, Portugal"},{"name":"QOPNA, Department of Chemistry, University of Aveiro, Aveiro, Portugal"}]},{"given":"Paula","family":"Oliveira","sequence":"additional","affiliation":[{"name":"CITAB, Department of Veterinary Sciences, University of Tr\u00e1s-os-Montes and Alto Douro, Vila Real, Portugal"}]},{"given":"Rita","family":"Ferreira","sequence":"additional","affiliation":[{"name":"QOPNA, Department of Chemistry, University of Aveiro, Aveiro, Portugal"}]},{"given":"Jose","family":"Duarte","sequence":"additional","affiliation":[{"name":"CIAFEL, Research Center in Physical Activity, Health and Leisure; Faculty of Sport, University of Porto, Porto, Portugal"}]}],"member":"194","published-online":{"date-parts":[[2018,8,10]]},"container-title":["International Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-0660-0198.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T23:47:32Z","timestamp":1541461652000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-0660-0198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,10]]},"references-count":0,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,11,5]]},"published-print":{"date-parts":[[2018,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-0660-0198","relation":{},"ISSN":["0172-4622","1439-3964"],"issn-type":[{"value":"0172-4622","type":"print"},{"value":"1439-3964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,10]]}}}