{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T16:27:16Z","timestamp":1670084836795},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PMIO"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The new polyketide laccaridione C (1) was obtained by bioassay-guided\n                    isolation of organic extracts of the fungal strain CF-223743, isolated from dung\n                    collected in a forest of Grand Comoros Island. Its structure was established\n                    using spectroscopic methods, namely HRMS and 1D and 2D NMR. The new compound was\n                    tested against seven cancer cell lines, evidencing effective activity against\n                    melanoma (A2058) with an IC50 of 13.2\u2009\u00b5M, and an\n                    increased activity against breast cancer (MCF-7) with an IC50  of\n                    3.7\u2009\u00b5M. The strain CF-223743 was taxonomically identified as\n                        Montagnula sp. based on ITS\/28S analysis<\/jats:p>","DOI":"10.1055\/a-1032-3346","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T19:05:39Z","timestamp":1574103939000},"page":"e57-e62","source":"Crossref","is-referenced-by-count":1,"title":["Laccaridione C, a Bioactive Polyketide from the Fungus\n                        Montagnula sp."],"prefix":"10.1055","volume":"6","author":[{"given":"Celso","family":"Almeida","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Microbiology, Armilla, Spain"}]},{"given":"Thomas Andrew","family":"Mackenzie","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Screening and Target Validation, Armilla,\n                    Spain"}]},{"given":"V\u00edctor","family":"Gonz\u00e1lez-Men\u00e9ndez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Microbiology, Armilla, Spain"}]},{"given":"Nuria","family":"de Pedro","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Screening and Target Validation, Armilla,\n                    Spain"}]},{"given":"Ignacio","family":"P\u00e9rez-Victoria","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Chemistry, Armilla, Spain"}]},{"given":"Gloria","family":"Crespo","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Chemistry, Armilla, Spain"}]},{"given":"Jes\u00fas","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Chemistry, Armilla, Spain"}]},{"given":"Olga","family":"Genilloud","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Microbiology, Armilla, Spain"}]},{"given":"Francisca","family":"Vicente","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Screening and Target Validation, Armilla,\n                    Spain"}]},{"given":"Bastien","family":"Cautain","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Screening and Target Validation, Armilla,\n                    Spain"}]},{"given":"Fernando","family":"Reyes","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Chemistry, Armilla, Spain"}]}],"member":"194","published-online":{"date-parts":[[2019,11,18]]},"container-title":["Planta Medica International Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1032-3346.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T21:19:19Z","timestamp":1574889559000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1032-3346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2019,8,21]]},"published-print":{"date-parts":[[2019,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1032-3346","relation":{},"ISSN":["2509-9264","2509-6656"],"issn-type":[{"value":"2509-9264","type":"print"},{"value":"2509-6656","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11]]}}}