{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:43:06Z","timestamp":1778546586174,"version":"3.51.4"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Colorectal cancer is now a frequently treatable illness for most and a\nchronic disease for many. The number of people living with a diagnosis of\ncolorectal cancer is thus expected to rise. Yet even after successful\ntreatment, colorectal cancer survivors, mostly the elderly, frequently\nexperience health problems and impaired health-related quality of life. We\ninvestigated the cross-sectional association between physical fitness,\nmeasured with the 6-min walk test, 30-second chair-stand test, and isometric\nhandgrip strength, as well as health-related quality of life, in a cohort of\ncolorectal cancer patients (n=71, mean [SD] age 67\u00b110 years,\n63% men; 35, 39 and 25% in stages I, II and III,\nrespectively). Greater performance in the 6-minute walk test and 30-second\nchair-stand test was associated with higher levels of global health status\n(p&lt;0.001, p=0.001 respectively), higher functioning\n(p&lt;0.001) and lower levels of symptomatology (p&lt;0.001; pain\nand fatigue). Additionally, greater 6-min walk test performance was\nassociated with a better cognitive function (p=0.005). Our results\nsuggest that greater aerobic fitness and lower-extremity muscle strength are\ncross-sectionally associated with higher levels of global health status,\nhigher functioning and lower levels of symptomatology such as pain and\nfatigue in colorectal cancer patients.<\/jats:p>","DOI":"10.1055\/a-1342-7347","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T01:06:28Z","timestamp":1614301588000},"page":"924-929","source":"Crossref","is-referenced-by-count":14,"title":["Physical Fitness and Health-related Quality of Life in Patients with Colorectal Cancer"],"prefix":"10.1055","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5929-4731","authenticated-orcid":false,"given":"Luisa","family":"Soares-Miranda","sequence":"additional","affiliation":[{"name":"Research Center in Physical Activity Health and Leisure, Faculty of\nSport, University of Porto, Porto, Portugal"}]},{"given":"Alejandro","family":"Lucia","sequence":"additional","affiliation":[{"name":"Research Institute of Hospital 12 de Octubre\n(\u2018i+12\u2019), Madrid, Spain"},{"name":"Universidad Europa de Madrid (Faculty of Sports Sciences), Madrid,\nSpain"}]},{"given":"Marco","family":"Silva","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar S\u00e3o\nJo\u00e3o, Porto, Portugal"}]},{"given":"Armando","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar S\u00e3o\nJo\u00e3o, Porto, Portugal"}]},{"given":"Rosa","family":"Ramalho","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar S\u00e3o\nJo\u00e3o, Porto, Portugal"}]},{"given":"Pedro Correia","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Surgery, Centro Hospitalar S\u00e3o Jo\u00e3o,\nPorto, Portugal"}]},{"given":"Jorge","family":"Mota","sequence":"additional","affiliation":[{"name":"Research Center in Physical Activity Health and Leisure, Faculty of\nSport, University of Porto, Porto, Portugal"}]},{"given":"Guilherme","family":"Macedo","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar S\u00e3o\nJo\u00e3o, Porto, Portugal"}]},{"given":"Sandra","family":"Abreu","sequence":"additional","affiliation":[{"name":"Research Center in Physical Activity Health and Leisure, Faculty of\nSport, University of Porto, Porto, Portugal"}]}],"member":"194","published-online":{"date-parts":[[2021,2,25]]},"reference":[{"key":"ref1","first-page":"89","article-title":"Epidemiology of colorectal cancer: Incidence, mortality, survival, and risk\nfactors","volume":"14","author":"P Rawla","year":"2019","journal-title":"Prz Gastroenterol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1186\/s12885-018-5075-1","article-title":"Health-related quality of life in long-term survivors of colorectal cancer and\nits association with all-cause mortality: A German cohort study","volume":"18","author":"I Ratjen","year":"2018","journal-title":"BMC Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0959-8049(02)00098-9","article-title":"Baseline quality of life predicts survival in patients with advanced colorectal\ncancer","volume":"38","author":"N R Maisey","year":"2002","journal-title":"Eur J Cancer"},{"key":"ref4","first-page":"126","article-title":"Physical activity, exercise, and physical fitness: Definitions and distinctions\nfor health-related research","volume":"100","author":"C J Caspersen","year":"1985","journal-title":"Public Health Rep"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"199","DOI":"10.12688\/f1000research.9795.1","article-title":"Recent advances in the link between physical activity, sedentary behavior,\nphysical fitness, and colorectal cancer","volume":"6","author":"V Namasivayam","year":"2017","journal-title":"F1000Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1001\/jamaoncol.2015.0226","article-title":"Midlife cardiorespiratory fitness, incident cancer, and survival after cancer in\nmen: The Cooper Center Longitudinal Study","volume":"1","author":"S G Lakoski","year":"2015","journal-title":"JAMA Oncol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s10552-007-9016-6","article-title":"Associations of leisure-time physical activity with quality of life in a large,\npopulation-based sample of colorectal cancer survivors","volume":"18","author":"B M Lynch","year":"2007","journal-title":"Cancer Causes Control"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1007\/s10350-008-9324-2","article-title":"Associations between exercise, quality of life, and fatigue in colorectal cancer\nsurvivors","volume":"51","author":"C J Peddle","year":"2008","journal-title":"Dis Colon Rectum"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1200\/JCO.2007.15.7917","article-title":"Prospective relationships of physical activity with quality of life among\ncolorectal cancer survivors","volume":"26","author":"B M Lynch","year":"2008","journal-title":"J Clin Oncol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12955-018-0934-7","article-title":"Quality of life and physical activity in long-term (>\/=5\nyears post-diagnosis) colorectal cancer survivors \u2013 systematic\nreview","volume":"16","author":"R E Eyl","year":"2018","journal-title":"Health Qual Life Outcomes"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s00520-015-2615-y","article-title":"Association between physical fitness, quality of life, and depression in stage\nII-III colorectal cancer survivors","volume":"23","author":"J Lee","year":"2015","journal-title":"Support Care Cancer"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/23809000.2018.1503538","article-title":"Physical activity and nutritional interventions and health-related quality of\nlife in colorectal cancer survivors: A review","volume":"3","author":"L Soares-Miranda","year":"2018","journal-title":"Expert Rev Qual Life Cancer Care"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00384-016-2671-x","article-title":"Cancer Survivor Study (CASUS) on colorectal patients: Longitudinal study on\nphysical activity, fitness, nutrition, and its influences on quality of life,\ndisease recurrence, and survival. Rationale and design","volume":"32","author":"L Soares-Miranda","year":"2017","journal-title":"Int J Colorectal Dis"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1055\/a-1015-3123","article-title":"Ethical standards in sport and exercise science research: 2020 update","volume":"40","author":"D J Harriss","year":"2019","journal-title":"Int J Sports Med"},{"key":"ref15","first-page":"127","article-title":"Development and validation of a functional fitness test for community-residing\nolder adults","volume":"6","author":"R E Rikli","year":"1999","journal-title":"J Aging Phys Act"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1055\/s-0032-1323746","article-title":"Validity of the six-minute walk test in cancer patients","volume":"34","author":"K Schmidt","year":"2013","journal-title":"Int J Sports Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1164\/rccm.167.2.211","article-title":"American College of Chest P. ATS\/ACCP Statement on cardiopulmonary\nexercise testing","volume":"167","author":"S Thoracic","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30: A\nquality-of-life instrument for use in international clinical trials in\noncology","volume":"85","author":"N K Aaronson","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"ref19","volume-title":"The EORTC QLQ-C30 Scoring Manual","author":"PA N Fayers","year":"2001","edition":"3rd edition"},{"key":"ref20","volume-title":"Physical status : The use of and interpretation of anthropometry","year":"1995"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/geront\/gns071","article-title":"Development and validation of criterion-referenced clinically relevant fitness\nstandards for maintaining physical independence in later years","volume":"53","author":"R E Rikli","year":"2013","journal-title":"Gerontologist"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"355","DOI":"10.4103\/IJPC.IJPC_65_17","article-title":"Effect of aerobic exercise on Cancer-related Fatigue","volume":"23","author":"J G Patel","year":"2017","journal-title":"Indian J Palliat Care"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.bbi.2007.03.013","article-title":"Cancer-related fatigue: Links with inflammation in cancer patients and\nsurvivors","volume":"21","author":"J E Bower","year":"2007","journal-title":"Brain Behav Immun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/j.bbi.2012.06.011","article-title":"Inflammation and cancer-related fatigue: Mechanisms, contributing factors, and\ntreatment implications","volume":"30","author":"J E Bower","year":"2013","journal-title":"Brain Behav Immun"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12955-018-0882-2","article-title":"Effect of exercise on pain and functional capacity in breast cancer\npatients","volume":"16","author":"A D Reis","year":"2018","journal-title":"Health Qual Life Outcomes"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1093\/annonc\/mdu448","article-title":"Cognitive function and fatigue after diagnosis of colorectal cancer","volume":"25","author":"J Vardy","year":"2014","journal-title":"Ann Oncol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nrn2298","article-title":"Be smart, exercise your heart: Exercise effects on brain and cognition","volume":"9","author":"C H Hillman","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.neuroimage.2017.11.007","article-title":"Effect of aerobic exercise on hippocampal volume in humans: A systematic review\nand meta-analysis","volume":"166","author":"J Firth","year":"2018","journal-title":"Neuroimage"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1365-2796.2010.02281.x","article-title":"Physical activity and risk of cognitive decline: A meta-analysis of prospective\nstudies","volume":"269","author":"F Sofi","year":"2011","journal-title":"J Intern Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3389\/fneur.2018.00698","article-title":"Endocrine crosstalk between skeletal muscle and the brain","volume":"9","author":"J Delezie","year":"2018","journal-title":"Front Neurol"}],"container-title":["International Journal of Sports Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1342-7347.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T23:23:39Z","timestamp":1631834619000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1342-7347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,25]]},"references-count":30,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,9,16]]},"published-print":{"date-parts":[[2021,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1342-7347","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0172-4622","1439-3964"],"issn-type":[{"value":"0172-4622","type":"print"},{"value":"1439-3964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,25]]}}}