{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T04:09:57Z","timestamp":1660277397264},"reference-count":12,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction Statin therapy is associated with an increased risk of\n                    developing diabetes. Among bariatric patients, the influence of this therapy on\n                    various metabolic outcomes, such as diabetes status and its remission, is\n                    largely unknown.<\/jats:p><jats:p>\n          Methods This was a retrospective study of 1710 patients who underwent\n                    bariatric surgery at our hospital between January\/2010 and\n                    June\/2017. We compared patients with and without statin therapy at\n                    baseline, 12 and 24 months after surgery regarding statin use and its impact on\n                    several clinical and analytical parameters. Multiple linear regression was\n                    performed, adjusting differences for age, sex, surgery type, antidiabetic drugs\n                    at baseline, hypertension at baseline, LDL cholesterol\n                    \u02c3\u2009130\u2009mg\/dL, weight variation one year after surgery,\n                    and age of obesity onset.<\/jats:p><jats:p>\n          Results The overall prevalence of statin use was 20.2% before,\n                    13.6% 12 months after surgery, and 15.0% 24 months after\n                    surgery. There was a larger reduction in fasting glucose and HbA1c at 12 and 24\n                    months after surgery among statin-treated patients, with the opposite trend for\n                    weight reduction and BMI. Statin-treated patients with diabetes had lower\n                    diabetes remission rates (45.3 vs 68.5%) 12 months after surgery,\n                    with the highest reduction in HbA1c (1.3\u00b11.3 vs\n                    \u22121.1\u00b11.2%; p=0.042), fasting glucose\n                    (\u221240.8\u00b148.8 vs\n                    \u221230.9\u00b141.6\u2009mg\/dL; p=0.028), and insulin\n                    (\u221221.7\u00b128.2 vs \u221213.4\u00b114.2 mIU\/L;\n                    p=0.039). The proportion of new-onset cases of diabetes was equal\n                    between statin-treated vs non-treated individuals at 12 months (1.9%)\n                    and 24 months (1.0%) after surgery.<\/jats:p><jats:p>\n          Conclusion Bariatric surgery seems to lead to diabetes remission more\n                    frequently in patients not treated with statins. A larger reduction was observed\n                    in fasting glucose and HbA1c among statin-treated patients. Statin did not\n                    contribute to an increased proportion of new-onset diabetes after surgery.<\/jats:p>","DOI":"10.1055\/a-1743-2335","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T23:58:37Z","timestamp":1648079917000},"page":"539-545","source":"Crossref","is-referenced-by-count":0,"title":["Statin Therapy Among Bariatric Patients: The Impact on Metabolic\n                    Outcomes and Diabetes Status"],"prefix":"10.1055","volume":"130","author":[{"given":"Fernando M","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo do Centro\n                    Hospitalar e Universit\u00e1rio de S. Jo\u00e3o"},{"name":"Faculdade de Medicina da Universidade do Porto"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em\n                    Sa\u00fade, Universidade do Porto"}]},{"given":"Maria M","family":"Silva","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo do Centro\n                    Hospitalar e Universit\u00e1rio de S. Jo\u00e3o"},{"name":"Faculdade de Medicina da Universidade do Porto"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em\n                    Sa\u00fade, Universidade do Porto"}]},{"given":"Marta","family":"Borges-Canha","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo do Centro\n                    Hospitalar e Universit\u00e1rio de S. Jo\u00e3o"},{"name":"Faculdade de Medicina da Universidade do Porto"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em\n                    Sa\u00fade, Universidade do Porto"}]},{"given":"Jo\u00e3o S","family":"Neves","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo do Centro\n                    Hospitalar e Universit\u00e1rio de S. Jo\u00e3o"},{"name":"Faculdade de Medicina da Universidade do Porto"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em\n                    Sa\u00fade, Universidade do Porto"}]},{"given":"Cl\u00e1udia","family":"Costa","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo do Centro\n                    Hospitalar e Universit\u00e1rio de S. Jo\u00e3o"}]},{"given":"Pedro M.","family":"Cabral","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Patologia Cl\u00ednica do Centro Hospitalar\n                    Universit\u00e1rio Cova da Beira"}]},{"given":"Vanessa","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo do Centro\n                    Hospitalar e Universit\u00e1rio de S. Jo\u00e3o"},{"name":"Faculdade de Medicina da Universidade do Porto"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em\n                    Sa\u00fade, Universidade do Porto"}]},{"given":"Rita","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias da Nutri\u00e7\u00e3o e\n                    Alimenta\u00e7\u00e3o da Universidade do Porto"}]},{"given":"Patr\u00edcia","family":"Meira","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias da Nutri\u00e7\u00e3o e\n                    Alimenta\u00e7\u00e3o da Universidade do Porto"}]},{"given":"Maria J","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo do Centro\n                    Hospitalar e Universit\u00e1rio de S. Jo\u00e3o"},{"name":"Faculdade de Medicina da Universidade do Porto"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em\n                    Sa\u00fade, Universidade do Porto"}]},{"given":"Daniela","family":"Salazar","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo do Centro\n                    Hospitalar e Universit\u00e1rio de S. Jo\u00e3o"},{"name":"Faculdade de Medicina da Universidade do Porto"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em\n                    Sa\u00fade, Universidade do Porto"}]},{"given":"Jorge","family":"Pedro","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo do Centro\n                    Hospitalar e Universit\u00e1rio de S. Jo\u00e3o"},{"name":"Faculdade de Medicina da Universidade do Porto"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em\n                    Sa\u00fade, Universidade do Porto"}]},{"given":"Ana","family":"Varela","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo do Centro\n                    Hospitalar e Universit\u00e1rio de S. Jo\u00e3o"},{"name":"Faculdade de Medicina da Universidade do Porto"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em\n                    Sa\u00fade, Universidade do Porto"}]},{"given":"Selma","family":"Souto","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo do Centro\n                    Hospitalar e Universit\u00e1rio de S. Jo\u00e3o"},{"name":"Faculdade de Medicina da Universidade do Porto"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em\n                    Sa\u00fade, Universidade do Porto"}]},{"given":"Eva","family":"Lau","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo do Centro\n                    Hospitalar e Universit\u00e1rio de S. Jo\u00e3o"},{"name":"Faculdade de Medicina da Universidade do Porto"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em\n                    Sa\u00fade, Universidade do Porto"}]},{"given":"Paula","family":"Freitas","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo do Centro\n                    Hospitalar e Universit\u00e1rio de S. Jo\u00e3o"},{"name":"Faculdade de Medicina da Universidade do Porto"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em\n                    Sa\u00fade, Universidade do Porto"}]},{"given":"Davide","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Endocrinologia, Diabetes e Metabolismo do Centro\n                    Hospitalar e Universit\u00e1rio de S. Jo\u00e3o"},{"name":"Faculdade de Medicina da Universidade do Porto"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em\n                    Sa\u00fade, Universidade do Porto"}]},{"given":"CRIO","family":"group","sequence":"additional","affiliation":[{"name":"Centro de responsabilidade integrada em Obesidade, Centro Hospitalar e\n                    Universit\u00e1rio de S. Jo\u00e3o"}]}],"member":"194","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.medcli.2017.11.030","article-title":"Statins: Pros and cons","volume":"150","author":"I Pinal-Fernandez","year":"2018","journal-title":"Med Clin"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/s41569-018-0098-5","article-title":"Safety and efficacy of statin therapy","volume":"15","author":"B B Adhyaru","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.numecd.2017.03.001","article-title":"Statin use and risk of new-onset diabetes: A meta-analysis of observational\n                    studies","volume":"27","author":"M Casula","year":"2017","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/pds.4020","article-title":"Statin use and the risk of developing diabetes: A network meta-analysis","volume":"25","author":"D Thakker","year":"2016","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.15537\/smj.2016.10.16078","article-title":"Do statins really cause diabetes? A meta-analysis of major randomized controlled\n                    clinical trials","volume":"37","author":"A J Rahal","year":"2016","journal-title":"Saudi Med J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.3390\/ijms21134725","article-title":"Statin treatment-induced development of type 2 diabetes: From clinical evidence\n                    to mechanistic insights","volume":"21","author":"U Galicia-Garcia","year":"2020","journal-title":"International J Mol Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nrgastro.2016.170","article-title":"Bariatric surgery for obesity and metabolic disorders: State of the art","volume":"14","author":"N T Nguyen","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.soard.2016.11.018","article-title":"Effects of statin therapy on weight loss and diabetes in bariatric patients","volume":"13","author":"B A Taylor","year":"2017","journal-title":"Surg Obes Relat Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1177\/000313481107700119","article-title":"Statins and the bariatric patient: characterization and perioperative effects of\n                    statin therapy in the gastric bypass patient","volume":"77","author":"M Perna","year":"2011","journal-title":"Am Surg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000511737","article-title":"Bariatric surgery impact on cardiovascular risk factors: Is age a factor to\n                    consider?","volume":"14","author":"F Mendon\u00e7a","year":"2021","journal-title":"Obes Facts"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosissup.2014.04.001","article-title":"The use of statins in people at risk of developing diabetes mellitus: Evidence\n                    and guidance for clinical practice","volume":"15","author":"N A Sattar","year":"2014","journal-title":"Atheroscler Suppl"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e011320","DOI":"10.1161\/JAHA.118.011320","article-title":"Time- and dose-dependent association of statin use with risk of clinically\n                    relevant new-onset diabetes mellitus in primary prevention: A nationwide\n                    observational cohort study","volume":"8","author":"M J Ko","year":"2019","journal-title":"J Am Heart Assoc"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1743-2335.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T22:57:52Z","timestamp":1660258672000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1743-2335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,23]]},"references-count":12,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2022,8,11]]},"published-print":{"date-parts":[[2022,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1743-2335","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,23]]}}}