{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T16:24:18Z","timestamp":1774542258242,"version":"3.50.1"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"15","funder":[{"DOI":"10.13039\/501100008530","name":"FEDER","doi-asserted-by":"crossref","award":["POCI-01-0145-FEDER-029767"],"award-info":[{"award-number":["POCI-01-0145-FEDER-029767"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100018886","name":"Laborat\u00f3rio Associado para a Qu\u00edmica Verde","doi-asserted-by":"crossref","award":["UIDB\/50006\/2020"],"award-info":[{"award-number":["UIDB\/50006\/2020"]}],"id":[{"id":"10.13039\/501100018886","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Centro de Investiga\u00e7\u00e3o em Materiais Cer\u00e2micos e Comp\u00f3sitos \u2013 Aveiro Institute of Materials","award":["UIDB\/50011\/2020"],"award-info":[{"award-number":["UIDB\/50011\/2020"]}]},{"name":"Centro de Investiga\u00e7\u00e3o em Materiais Cer\u00e2micos e Comp\u00f3sitos \u2013 Aveiro Institute of Materials","award":["UIDP\/50011\/2020"],"award-info":[{"award-number":["UIDP\/50011\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synlett"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A mild synthesis of 3,5-disubstituted nitrobenzenes from readily available 3-formylchromones is reported. The developed methodology follows a cascade process, promoted by 1,8-diazabicyclo[5.4.0]undec-7-ene. The proposed mechanism involves an initial Michael addition of nitromethane at C-2 of a 3-formylchromone. The resultant intermediate undergoes another Michael reaction with a second 3-formylchromone molecule. After ring closure through intramolecular cyclization, the aromatization is completed by deformylation, affording the 3,5-disubstituted nitrobenzenes in 52\u201386% yield. The reported method produces three new C\u2013C bonds in a simple and straightforward manner, and it is consistent with gram-scale synthesis.<\/jats:p>","DOI":"10.1055\/a-1875-2646","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T23:15:55Z","timestamp":1655162155000},"page":"1505-1510","source":"Crossref","is-referenced-by-count":1,"title":["Mild Synthesis of Symmetric 3,5-Disubstituted Nitrobenzenes"],"prefix":"10.1055","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":false,"given":"Artur M. S.","family":"Silva","sequence":"first","affiliation":[{"name":"LAQV-REQUIMTE, Department of Chemistry, University of Aveiro"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5905-3316","authenticated-orcid":false,"given":"H\u00e9lio M. 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