{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:51:12Z","timestamp":1768467072279,"version":"3.49.0"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:p>\n            Background\u2002Endoscopic submucosal dissection (ESD) in colorectal lesions is technically demanding and a significant rate of noncurative procedures is expected. We aimed to assess the rate of residual lesions after a noncurative ESD for colorectal cancer (CRC) and to establish predictive scores to be applied in the clinical setting.<\/jats:p><jats:p>\n            Methods\u2002Retrospective multicenter analysis of consecutive colorectal ESDs. Patients with noncurative ESDs performed for the treatment of CRC lesions submitted to complementary surgery or with at least one follow-up endoscopy were included. <\/jats:p><jats:p>\n            Results\u2002From 2255 colorectal ESDs, 381 (17\u200a%) were noncurative, and 135 of these were performed in CRC lesions. A residual lesion was observed in 24 patients (18\u200a%). Surgery was performed in 96 patients and 76 (79\u200a%) had no residual lesion in the colorectal wall or in the lymph nodes. The residual lesion rate for sm1 cancers was 0\u200a%, and for &gt;\u200asm1 cancers was also 0\u200a% if no other risk factors were present. Independent risk factors for lymph node metastasis were poor differentiation and lymphatic permeation (NC-Lymph score). Risk factors for the presence of a residual lesion in the wall were piecemeal resection, poor differentiation, and positive\/indeterminate vertical margin (NC-Wall score).<\/jats:p><jats:p>\n            Conclusions\u2002Lymphatic permeation or poor differentiation warrant surgery owing to their high risk of lymph node metastasis, mainly in &gt;\u200asm1 cancers. In the remaining cases, en bloc and R0 resections resulted in a low risk of residual lesions in the wall. Our scores can be a useful tool for the management of patients who undergo noncurative colorectal ESDs.<\/jats:p>","DOI":"10.1055\/a-1906-8000","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T22:49:00Z","timestamp":1658443740000},"page":"235-244","source":"Crossref","is-referenced-by-count":14,"title":["Risk of residual neoplasia after a noncurative colorectal endoscopic submucosal dissection for malignant lesions: a multinational study"],"prefix":"10.1055","volume":"55","clinical-trial-number":[{"clinical-trial-number":"nct04484311","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-0576","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Santos-Antunes","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Faculty of Medicine, Centro Hospitalar Universit\u00e1rio S. Jo\u00e3o, Porto, Portugal"},{"name":"Ipatimup\/i3S (Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto), Porto, Portugal"}]},{"given":"Mathieu","family":"Pioche","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology, Edouard Herriot Hospital, Lyon, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0365-1231","authenticated-orcid":false,"given":"Felipe","family":"Ramos-Zabala","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Department of Clinical Medical Sciences, Hospital Universitario HM Montepr\u00edncipe, HM Hospitales, Universidad San Pablo-CEU, CEU Universities Madrid, Madrid, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1870-5952","authenticated-orcid":false,"given":"Paolo","family":"Cecinato","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Azienda USL \u2013 IRCCS di Reggio Emilia, Reggio Emilia, Italy"}]},{"given":"Francisco J.","family":"Gallego Rojo","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital de Poniente, Almer\u00eda, Spain"}]},{"given":"Pedro","family":"Barreiro","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar Lisboa Ocidental EPE, Lisbon, Portugal"},{"name":"Lisbon Advanced Endoscopic Center, Hospital Lus\u00edadas, Lisbon, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1605-0200","authenticated-orcid":false,"given":"Catarina","family":"F\u00e9lix","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar Lisboa Ocidental EPE, Lisbon, Portugal"}]},{"given":"Sandro","family":"Sferrazza","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Santa Chiara Hospital, Trento, Italy"}]},{"given":"Frieder","family":"Berr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Clinics Salzburg, Paracelsus Medical University, Salzburg, Austria"}]},{"given":"Andrej","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, University Clinics Salzburg, Paracelsus Medical University, Salzburg, Austria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6256-0167","authenticated-orcid":false,"given":"Arnaud","family":"Lemmers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, CUB Erasme Hospital, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"}]},{"given":"Mariana","family":"Figueiredo Ferreira","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, CUB Erasme Hospital, Universit\u00e9 Libre de Bruxelles (ULB), Brussels, Belgium"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9311-3746","authenticated-orcid":false,"given":"Eduardo","family":"Alb\u00e9niz","sequence":"additional","affiliation":[{"name":"Navarrabiomed Research Institute, Complejo Hospitalario de Navarra, Public University of Navarra, IdiSNA, Pamplona, Spain"}]},{"given":"Hugo","family":"Uchima","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Service, Centro M\u00e9dico Teknon, Barcelona, Spain"},{"name":"Gastroenterology Service, Hospital Universitario Germans Trias i Pujol, Barcelona, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8522-5756","authenticated-orcid":false,"given":"Ricardo","family":"K\u00fcttner-Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Santo Ant\u00f3nio, Centro Hospitalar Universit\u00e1rio do Porto, Porto, Portugal"}]},{"given":"Carlos","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Centro Hospitalar de Vila Nova de Gaia\/Espinho, Vila Nova de Gaia, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1293-3353","authenticated-orcid":false,"given":"Rui","family":"Morais","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Faculty of Medicine, Centro Hospitalar Universit\u00e1rio S. Jo\u00e3o, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3471-8304","authenticated-orcid":false,"given":"Sunil","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Westmead Hospital, Sydney, Australia"}]},{"given":"Daniel","family":"Martinho-Dias","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Information and Decision in Health, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Elisabete","family":"Rios","sequence":"additional","affiliation":[{"name":"Pathology Department, Faculty of Medicine, Centro Hospitalar Universit\u00e1rio S. Jo\u00e3o, Porto, Portugal"}]},{"given":"Isabel","family":"Faria-Ramos","sequence":"additional","affiliation":[{"name":"Ipatimup\/i3S (Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade da Universidade do Porto), Porto, Portugal"}]},{"given":"Margarida","family":"Marques","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Faculty of Medicine, Centro Hospitalar Universit\u00e1rio S. Jo\u00e3o, Porto, Portugal"}]},{"given":"Michael J.","family":"Bourke","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Westmead Hospital, Sydney, Australia"}]},{"given":"Guilherme","family":"Macedo","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Faculty of Medicine, Centro Hospitalar Universit\u00e1rio S. 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