{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:48:13Z","timestamp":1768690093508,"version":"3.49.0"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"17","funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UIDP\/50006\/2020"],"award-info":[{"award-number":["UIDP\/50006\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synlett"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A well-known squaramide-cinchonine organocatalyst was immobilized in a controlled way onto three types of commercial porous glass beads EziG\u2122 (EziG OPAL, EziG Amber, and EziG Coral) and applied in asymmetric Michael reactions. The performance of the immobilized catalysts was evaluated under batch and continuous-flow conditions, showing promising results in both approaches. In batch reactions, 0.8 and 1.6 mol% of the immobilized cinchonine-squaramide provided the products with excellent yields (up to 99%) and enantioselectivities (up to 99% ee). These excellent results were also verified in the case of continuous-flow reactions, where also 0.8 and 1.6 mol% of the catalyst immobilized onto the glass beads afforded the product with extraordinary yields (up to 99%) and very high enantioselectivities (up to 97% ee). The immobilized catalysts could be recycled (up to seven cycles) using both approaches.<\/jats:p>","DOI":"10.1055\/a-1916-4858","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T22:54:54Z","timestamp":1659480894000},"page":"1756-1762","source":"Crossref","is-referenced-by-count":6,"title":["Immobilization of Functionalized epi-Cinchonine Organocatalysts on Controlled Porous Glass Beads: Applications in Batch and \u00adContinuous Flow"],"prefix":"10.1055","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8248-1116","authenticated-orcid":false,"given":"Anthony J.","family":"Burke","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, University of Coimbra"},{"name":"Coimbra Chemistry Centre, Institute of Molecular Sciences, Chemistry Department, University of Coimbra"}]},{"given":"Ana C.","family":"Amorim","sequence":"additional","affiliation":[{"name":"Chiratecnics, LDA, PO Box, 59, Rossio, \u00c9vora, 7006-802, Portugal Laboratory 007, Building A, Col\u00e9gio Pedro de Fonseca, University of \u00c9vora"}]},{"given":"Daniela P.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Chemistry and Biochemistry Department, School of Science and Technology, University of Evora"},{"name":"LAQV-REQUIMTE, Institute for Research and Advanced Studies, University de \u00c9vora"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8117-7737","authenticated-orcid":false,"given":"Elisabete P.","family":"Carreiro","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Institute for Research and Advanced Studies, University de \u00c9vora"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5726-4881","authenticated-orcid":false,"given":"Gesine J.","family":"Hermann","sequence":"additional","affiliation":[{"name":"Chiratecnics, LDA, PO Box, 59, Rossio, \u00c9vora, 7006-802, Portugal Laboratory 007, Building A, Col\u00e9gio Pedro de Fonseca, University of \u00c9vora"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5781-1689","authenticated-orcid":false,"given":"Hans-J\u00fcrgen","family":"Federsel","sequence":"additional","affiliation":[{"name":"RISE, Research Institutes of Sweden"}]}],"member":"194","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/anie.197104961","volume":"10","author":"U Eder","year":"1971","journal-title":"Angew. 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