{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:12:53Z","timestamp":1774444373065,"version":"3.50.1"},"reference-count":89,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tumors present dysfunctional vasculature that limits blood perfusion and hinders\n                    immune cells delivery. We aimed to investigate if regular voluntary running\n                    promotes tumor vascular remodelling, improves intratumoral immune cells\n                    infiltration and inhibits tumor growth. Tumors were induced in C57BL\/6\n                    male mice (n=28) by subcutaneous inoculation in the dorsal region with a\n                    suspension of RM1 cells (1.5\u00d7105\n                    cells\/500\u2009\u00b5L PBS) and randomly allocated into two\n                    groups: sedentary (n=14) and voluntarily exercised on a wheel\n                    (n=14). Seven mice from each group were sacrificed 14 and 28 days after\n                    cells\u2019 inoculation to evaluate tumor weight, microvessel density,\n                    vessels\u2019 lumen regularity and the intratumoral quantity of NKG2D\n                    receptors, CD4+and CD8+T cells, by\n                    immunohistochemistry. The statistical inference was done through a two-way\n                    ANOVA. Exercised mice developed smaller tumors at 14 (0.17\u00b10.1\u2009g\n                    vs. 0.48\u00b10.2\u2009g, p&lt;0.05) and 28\n                    (0.92\u00b10.7\u2009g vs. 2.09\u00b11.3\u2009g, p&lt;0.05)\n                    days, with higher microvessel density (21.20\u00b13.2 vs. 15.86\u00b14.0\n                    vessels\/field, p&lt;0.05), more regular vessels\u2019 lumen\n                    (1.06\u00b10.2 vs. 1.43\u00b10.2, p&lt;0.05), and higher\n                        CD8+T cells (464.95\u00b148.0 vs. 364.70\u00b149.4\n                        cells\/mm2, p&lt;0.01), after 28 days. NKG2D\n                    expression was higher in exercised mice at 14 (263.27\u00b125.8\n                        cells\/mm2, p&lt;0.05) and 28 (295.06\u00b156.2\n                        cells\/mm2, p&lt;0.001) days. Regular voluntary\n                    running modulates tumor vasculature, increases immune cells infiltration and\n                    attenuates tumor growth, in mice.<\/jats:p>","DOI":"10.1055\/a-2008-7732","type":"journal-article","created":{"date-parts":[[2023,3,18]],"date-time":"2023-03-18T00:01:15Z","timestamp":1679097675000},"page":"427-437","source":"Crossref","is-referenced-by-count":2,"title":["Regular Voluntary Running is Associated with Increased Tumor\n                    Vascularization and Immune Cell Infiltration and Decreased Tumor Growth in\n                    Mice"],"prefix":"10.1055","volume":"44","author":[{"given":"M\u00e1rio","family":"Esteves","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o, Inova\u00e7\u00e3o e\n                    Desenvolvimento Fernando Pessoa (FP-I3ID), Escola Superior de Saude Fernando\n                    Pessoa, Porto, Portugal"},{"name":"Laboratory of Biochemistry and Experimental Morphology, CIAFEL, Porto,\n                    Portugal"}]},{"given":"Carina","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Experimental Morphology, CIAFEL, Porto,\n                    Portugal"}]},{"given":"Ant\u00f3nio","family":"Bovolini","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Experimental Morphology, CIAFEL, Porto,\n                    Portugal"}]},{"given":"Sofia S.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Endocrinology, Unit for Multidisciplinary\n                    Research in Biomedicine, University of Porto Institute of Biomedical Sciences\n                    Abel Salazar, Porto, Portugal"}]},{"given":"Tiago","family":"Morais","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Endocrinology, Unit for Multidisciplinary\n                    Research in Biomedicine, University of Porto Institute of Biomedical Sciences\n                    Abel Salazar, Porto, Portugal"}]},{"given":"\u00c2ngela","family":"Moreira","sequence":"additional","affiliation":[{"name":"Communication Unit, Universidade do Porto Instituto de\n                    Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Porto,\n                    Portugal"}]},{"given":"Madalena M.","family":"Costa","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Endocrinology, Unit for Multidisciplinary\n                    Research in Biomedicine, University of Porto Institute of Biomedical Sciences\n                    Abel Salazar, Porto, Portugal"}]},{"given":"Mariana P","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Endocrinology, Unit for Multidisciplinary\n                    Research in Biomedicine, University of Porto Institute of Biomedical Sciences\n                    Abel Salazar, Porto, Portugal"}]},{"given":"Jose Alberto","family":"Duarte","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry and Experimental Morphology, CIAFEL, Porto,\n                    Portugal"},{"name":"TOXRUN, University Institute of Health Sciences, CESPU, Gandra,\n                    Portuga"}]}],"member":"194","published-online":{"date-parts":[[2023,3,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality\n                    worldwide for 36 cancers in 185 countries","volume":"71","author":"H Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1101\/gad.314617.118","article-title":"Roles of the immune system in cancer: from tumor initiation to metastatic\n                    progression","volume":"32","author":"H Gonzalez","year":"2018","journal-title":"Genes 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