{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T09:59:37Z","timestamp":1697536777804},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Purpose Posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS) are often complicated by vasospasm and ischemia. Monitoring with transcranial color-coded Doppler (TCCD) could be useful, but its role is not established. We studied the incidence of ultrasonographic vasospasm (uVSP) in PRES\/RCVS and its relationship with ischemic lesions and clinical outcome.<\/jats:p><jats:p>\n            Materials and Methods We conducted a multicenter retrospective study of all patients with PRES\/RCVS from 2008 to 2020 who underwent TCCD and magnetic resonance imaging (MRI). TCCD exams were analyzed for uVSP. Diffusion-weighted MRI was analyzed for positive lesions (DWI-positive). Functional outcome was assessed by modified Rankin scale (mRS) at 90 days. The associations with outcomes were determined by logistic regression.<\/jats:p><jats:p>\n            Results We included 80 patients (mean age of 46 (standard deviation, 17) years; 66% females; 41 with PRES, 28 with RCVS and 11 with overlap phenotype). uVSP was detected in 25 (31%) patients. DWI-positive lesions were more often detected in uVSP-positive than uVSP-negative patients (36% vs. 15%; adjusted odds ratio [aOR] 4.05 [95% CI 1.06 \u2013 15.5], P=0.04). DWI-positive lesions were independently associated with worse functional prognosis (mRS 2\u20136, 43% vs. 10%; aOR, 10 [95% CI 2.6 \u2013 43], P&lt;0.01). Having additional uVSP further increased the odds of a worse outcome (P interaction=0.03).<\/jats:p><jats:p>\n            Conclusion Ultrasonographic vasospasm was detected in a third of patients with PRES\/RCVS and was associated with brain ischemic lesions. TCCD bedside monitoring can help to stratify patients at risk for cerebral ischemia, a strong predictor of functional outcome.<\/jats:p>","DOI":"10.1055\/a-2127-9459","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:52:00Z","timestamp":1692831120000},"page":"487-494","source":"Crossref","is-referenced-by-count":1,"title":["Ultrasonographic Vasospasm and Outcome of Posterior Reversible Encephalopathy and Cerebral Vasoconstriction Syndromes"],"prefix":"10.1055","volume":"44","author":[{"given":"Maria Jo\u00e3o","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal"}]},{"given":"Miguel","family":"Schon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospitalar Universit\u00e1rio Lisboa Norte EPE, Lisboa, Portugal"}]},{"given":"Jo\u00e3o Andr\u00e9","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Universidade de Coimbra Faculdade de Medicina, Coimbra, Portugal"}]},{"given":"Jo\u00e3o","family":"Filipe","sequence":"additional","affiliation":[{"name":"Neuroradiology, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal"}]},{"given":"Andreia","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal"},{"name":"Department of Clinical Neurosciences and Mental Health, University of Porto Faculty of Medicine, Porto, Portugal"}]},{"given":"Elsa","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal"},{"name":"Department of Clinical Neurosciences and Mental Health, University of Porto Faculty of Medicine, Porto, Portugal"},{"name":"Cardiovascular Research and Development Unit, University of Porto Faculty of Medicine, Porto, Portugal"}]},{"given":"Jo\u00e3o","family":"Sargento-Freitas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Universidade de Coimbra Faculdade de Medicina, Coimbra, Portugal"}]},{"given":"Fernando","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Neurology, Universidade de Coimbra Faculdade de Medicina, Coimbra, Portugal"}]},{"given":"Ana Catarina","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospitalar Universit\u00e1rio Lisboa Norte EPE, Lisboa, Portugal"},{"name":"IMM, Universidade de Lisboa Instituto de Medicina Molecular, Lisboa, Portugal"}]},{"given":"Pedro","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospitalar Universitario de Sao Joao, Porto, Portugal"},{"name":"Department of Clinical Neurosciences and Mental Health, University of Porto Faculty of Medicine, Porto, Portugal"},{"name":"Cardiovascular Research and Development Unit, University of Porto Faculty of Medicine, Porto, Portugal"}]}],"member":"194","published-online":{"date-parts":[[2023,8,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/S1474-4422(12)70135-7","article-title":"Reversible cerebral vasoconstriction syndrome","volume":"11","author":"A Ducros","year":"2012","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/S1474-4422(15)00111-8","article-title":"Posterior reversible encephalopathy syndrome: clinical and radiological manifestations, pathophysiology, and outstanding questions","volume":"14","author":"JE Fugate","year":"2015","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.3174\/ajnr.A4214","article-title":"Reversible Cerebral Vasoconstriction Syndrome, Part 1: Epidemiology, Pathogenesis, and Clinical 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