{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T04:16:09Z","timestamp":1770524169240,"version":"3.49.0"},"reference-count":43,"publisher":"Georg Thieme Verlag KG","issue":"01","funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"crossref","award":["PPM-00229-16; APQ-00068-18"],"award-info":[{"award-number":["PPM-00229-16; APQ-00068-18"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"crossref","award":["MCTI\/FINEP\/MS\/SCTIE\/DECIT-01\/2013"],"award-info":[{"award-number":["MCTI\/FINEP\/MS\/SCTIE\/DECIT-01\/2013"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Glioblastoma is the most frequent primary malignant brain tumor without effective treatment, which makes this work extremely relevant. The study of the bioactive compounds from medicinal\n          plants plays an important role in the discovery of new drugs.<\/jats:p><jats:p>This research investigated the constituents of Tapirira guianensis and its antitumor potential (in vitro and in vivo) in glioblastoma. The T. guianensis extracts\n          were characterized by mass spectrometry. The ethyl acetate partition (01ID) and its fractions 01ID-F2 and 01ID-F4 from T. guianensis showed potential antitumor treatment evidenced by\n          selective cytotoxicity for GAMG with IC50 14.1\u2009\u00b5g\/mL, 83.07\u2009\u00b5g\/mL, 59.27\u2009\u00b5g\/mL and U251 with IC50 25.92\u2009\u00b5g\/mL, 37.3\u2009\u00b5g\/mL and 18.84\u2009\u00b5g\/mL. Fractions 01ID-F2 and 01ID-F4 were 10 times more\n          selective when compared to TMZ and 01ID for the two evaluated cell lines. T. guianensis also reduced matrix metalloproteinases 2\u200a\u2013\u200a01ID-F2 (21.84%), 01ID-F4 (29.6%) and 9\u200a\u2013\u200a01ID-F4\n          (73.42%), ID-F4 (53.84%) activities, and induced apoptosis mainly through the extrinsic pathway. Furthermore, all treatments significantly reduced tumor size (01ID p\u2009&lt;\u20090,01,\n          01ID-F2\u2009p\u2009&lt;\u20090,01 and 01ID-F4\u2009p\u2009&lt;\u20090,0001) and caused blood vessels to shrink in vivo. The present findings highlight that T. guianensis exhibits considerable antitumor\n          potential in preclinical studies of glioblastoma. This ability may be related to the phenolic compounds and sesquiterpene derivatives identified in the extracts. This study deserves further\n          in vivo research, followed by clinical investigation.<\/jats:p>","DOI":"10.1055\/a-2181-2569","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T22:59:20Z","timestamp":1697237960000},"page":"13-24","source":"Crossref","is-referenced-by-count":1,"title":["Tapirira guianensis is Selectively Cytotoxic, Induces Apoptosis to the Glioblastoma and Decreases Tumor Growth and Angiogenesis in vivo"],"prefix":"10.1055","volume":"90","author":[{"given":"Ana Gabriela Silva","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Experimental Pathology Laboratory, Midwest Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei, Divin\u00f3polis, Brazil"}]},{"given":"Marina Andrade","family":"Rocha","sequence":"additional","affiliation":[{"name":"Experimental Pathology Laboratory, Midwest Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei, Divin\u00f3polis, Brazil"}]},{"given":"Lucas Santos","family":"de Azevedo","sequence":"additional","affiliation":[{"name":"Experimental Pathology Laboratory, Midwest Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei, Divin\u00f3polis, Brazil"}]},{"given":"Aline Thaynara de Moura","family":"Coelho","sequence":"additional","affiliation":[{"name":"Experimental Pathology Laboratory, Midwest Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei, Divin\u00f3polis, Brazil"}]},{"given":"Rafael C\u00e9sar Russo","family":"Chagas","sequence":"additional","affiliation":[{"name":"Experimental Pathology Laboratory, Midwest Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei, Divin\u00f3polis, Brazil"}]},{"given":"H\u00e9lio Batista","family":"Santos","sequence":"additional","affiliation":[{"name":"Tissue Processing Laboratory, Midwest Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei, Divin\u00f3polis, Brazil"}]},{"given":"Ralph Gruppi","family":"Thom\u00e9","sequence":"additional","affiliation":[{"name":"Tissue Processing Laboratory, Midwest Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei, Divin\u00f3polis, Brazil"}]},{"given":"Peter","family":"Samuel","sequence":"additional","affiliation":[{"name":"Zurich University of Applied Sciences, Department of Life Sciences and Facility Management, W\u00e4denswil, Switzerland"}]},{"given":"Evelyn","family":"Wolfram","sequence":"additional","affiliation":[{"name":"Zurich University of Applied Sciences, Department of Life Sciences and Facility Management, W\u00e4denswil, Switzerland"}]},{"given":"Bonglee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea"}]},{"given":"Rui Manuel","family":"Reis","sequence":"additional","affiliation":[{"name":"Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil"},{"name":"Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7374-4743","authenticated-orcid":false,"given":"Rosy Iara Maciel Azambuja","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Experimental Pathology Laboratory, Midwest Campus, Federal University of S\u00e3o Jo\u00e3o del-Rei, Divin\u00f3polis, Brazil"}]}],"member":"194","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/S0140-6736(18)30990-5","article-title":"Primary brain tumors in adults","volume":"392","author":"S Lapointe","year":"2018","journal-title":"The Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.3390\/cancers14102412","article-title":"Epidemiology of glioblastoma multiforme\u2013Literature review","volume":"14","author":"S Grochans","year":"2022","journal-title":"Cancers 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