{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:40:47Z","timestamp":1775893247245,"version":"3.50.1"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n            Background Pan-intestinal capsule endoscopy (PCE) evaluates the small bowel and colon noninvasively. This study evaluated diagnostic accuracy and safety of PCE vs. colonoscopy as first-line examination in suspected mid\u2013lower gastrointestinal bleeding (MLGIB).<\/jats:p><jats:p>\n            Methods In this prospective, single-center, single-blinded cohort study, consecutive patients with suspected MLGIB underwent PCE followed by same-day colonoscopy. Diagnostic accuracy for potentially hemorrhagic lesions (PHLs; combined diagnosis by PCE + colonoscopy) and incidence of adverse events were assessed. <\/jats:p><jats:p>\n            Results 100 patients were included (median age 70 [range 18\u201392] years; 65% female). PHLs were diagnosed in 46 patients, including small-bowel and\/or colon angioectasias in 32. PCE correctly identified 54 individuals without PHLs, and 95.7% (44\/46) of those with PHLs vs. 50.0% (23\/46) for colonoscopy (P&lt;0.01). PHLs were detected by PCE alone in 65.2% (30\/46), both examinations in 28.3% (13\/46), and colonoscopy alone in 6.5% (3\/46). PHLs were diagnosed at the ileocolonic region in 28% of patients, with PCE diagnosing 25\/28 cases (89.3%) and colonoscopy diagnosing 23\/28 (82.1%; P=0.13). Interventional procedures were performed at colonoscopy in 13\/81 patients with iron-deficiency anemia (16.0%) vs. 6\/19 patients with overt bleeding (31.6%; P&lt;0.01). No significant adverse events occurred with PCE vs. 2% with colonoscopy.<\/jats:p><jats:p>\n            Conclusions In patients with MLGIB, PCE avoided further invasive procedures in &gt;50% of patients. PCE was safe and more effective than colonoscopy in identifying PHL both in the small bowel and colon. These results support the potential use of PCE as first-line examination in patients with suspected MLGIB.<\/jats:p>","DOI":"10.1055\/a-2270-4601","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:33:51Z","timestamp":1708130031000},"page":"572-580","source":"Crossref","is-referenced-by-count":16,"title":["Pan-intestinal capsule endoscopy as first-line procedure in patients with suspected mid or lower gastrointestinal bleeding"],"prefix":"10.1055","volume":"56","clinical-trial-number":[{"clinical-trial-number":"nct04782986","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2885-0720","authenticated-orcid":false,"given":"Bruno","family":"Rosa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital da Senhora da Oliveira, Guimar\u00e3es, Portugal"},{"name":"Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal"},{"name":"ICVS\/3B\u2019s, PT Government Associate Laboratory, Braga, Portugal"}]},{"given":"Tiago","family":"C\u00fardia Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital da Senhora da Oliveira, Guimar\u00e3es, Portugal"},{"name":"Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal"},{"name":"ICVS\/3B\u2019s, PT Government Associate Laboratory, Braga, Portugal"}]},{"given":"Maria J.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital da Senhora da Oliveira, Guimar\u00e3es, Portugal"},{"name":"Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal"},{"name":"ICVS\/3B\u2019s, PT Government Associate Laboratory, Braga, Portugal"}]},{"given":"Francisca","family":"Dias de Castro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital da Senhora da Oliveira, Guimar\u00e3es, Portugal"},{"name":"Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal"},{"name":"ICVS\/3B\u2019s, PT Government Associate Laboratory, Braga, Portugal"}]},{"given":"Bernardo","family":"Sousa-Pinto","sequence":"additional","affiliation":[{"name":"MEDCIDS, Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"CINTESIS, Center for Health Technology and Services Research, University of Porto, Porto, Portugal"}]},{"given":"M\u00e1rio","family":"Dinis-Ribeiro","sequence":"additional","affiliation":[{"name":"MEDCIDS, Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal"},{"name":"RISE@CI-IPO (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) \/ Porto Comprehensive Cancer Center (Porto.CCC), Porto, Portugal"}]},{"given":"Jos\u00e9","family":"Cotter","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital da Senhora da Oliveira, Guimar\u00e3es, Portugal"},{"name":"Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal"},{"name":"ICVS\/3B\u2019s, PT Government Associate Laboratory, Braga, Portugal"}]}],"member":"194","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"E1235","DOI":"10.1055\/a-0677-170","article-title":"Evaluation of a new pan-enteric video capsule endoscopy system in patients with suspected or established inflammatory bowel disease \u2013 feasibility study","volume":"6","author":"R Eliakim","year":"2018","journal-title":"Endosc Int Open"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.cgh.2015.01.031","article-title":"Safety and feasibility of using the second-generation pillcam colon capsule to assess active colonic Crohn\u2019s disease","volume":"13","author":"G D\u2019Haens","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/MEG.0000000000002114","article-title":"A new panenteric capsule endoscopy-based strategy in patients with melena and a negative upper gastrointestinal endoscopy: a prospective feasibility study","volume":"33","author":"A Mussetto","year":"2021","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref4","first-page":"580","article-title":"Pan-enteric capsule for bleeding high-risk patients. 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