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The phytochemical composition was analysed by LC-MS\/MS while the antioxidant capacity was evaluated using DPPH, ABTS, and FRAP assays. The neutrophil migration was assessed using a CuSO4-induced inflammation model in a transgenic zebrafish line (Tg(mpx\u200a:\u200aGFP)i114). Three days post-fertilisation zebrafish larvae were treated with 5 and 25\u2009\u00b5g\/mL extract for 1\u2009h and then exposed to 10\u2009\u00b5M CuSO4 for 40\u2009min. Following exposure, various biochemical markers were assessed, along with neurobehavioral effects. The polyphenolic profile revealed a high flavonoid content and good antioxidant properties confirmed by the DPPH, ABTS, and FRAP assays. The extract reduced neutrophil migration in a concentration-dependent manner,\n          indicating anti-inflammatory activity. Additionally, it decreased reactive oxygen species (ROS) production and cell death without affecting mitochondrial membrane potential. The extract also mitigated oxidative damage, as shown by reduced malondialdehyde and protein carbonylation levels, alongside decreased antioxidant response markers. Neurobehavioral effects induced by CuSO4 were alleviated, as evidenced by improved touch-evoked responses. These findings suggest that almond-skin extract holds significant antioxidant and anti-inflammatory properties, possibly through modulation of ROS and calcium signalling pathways.<\/jats:p>","DOI":"10.1055\/a-2654-9426","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T23:00:36Z","timestamp":1759359636000},"page":"850-861","source":"Crossref","is-referenced-by-count":1,"title":["Anti-inflammatory and Antioxidant Properties of Almond-Skin Acetonic Extract in Zebrafish (Danio rerio) Copper-Sulphate-induced Inflammation"],"prefix":"10.1055","volume":"91","author":[{"given":"R\u00faben","family":"Barbosa","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences (ECVA), University of Tr\u00e1s-os-Montes and Alto Douro (UTAD), Vila Real, Portugal"}]},{"given":"Ana","family":"Martins","sequence":"additional","affiliation":[{"name":"School of Life and Environmental Sciences (ECVA), University of Tr\u00e1s-os-Montes and Alto 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Portugal"}]},{"given":"Carlos","family":"Ven\u00e2ncio","sequence":"additional","affiliation":[{"name":"Centre for the Research and Technology of Agroenvironmental and Biological Sciences, CITAB, Inov4Agro, UTAD, Vila Real, Portugal"},{"name":"Animal and Veterinary Research Centre (CECAV), UTAD, Vila Real, Portugal"}]},{"given":"Lu\u00eds","family":"F\u00e9lix","sequence":"additional","affiliation":[{"name":"Centre for the Research and Technology of Agroenvironmental and Biological Sciences, CITAB, Inov4Agro, UTAD, Vila Real, Portugal"}]}],"member":"194","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/ni.3790","article-title":"A guiding map for inflammation","volume":"18","author":"M G Netea","year":"2017","journal-title":"Nat Immunol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.cell.2015.02.010","article-title":"Homeostasis, inflammation, and disease 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