{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T10:00:33Z","timestamp":1767952833330,"version":"3.49.0"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Esophagogastric junction (EGJ) lesions are uncommon and histologically diverse. Among these, EGJ hyperplastic lesions are rare and generally considered benign. However, their nonspecific appearance makes accurate endoscopic identification challenging. Endoscopic resection is both a diagnostic and therapeutic approach, yet risk factors for neoplastic transformation in EGJ lesions remain unclear. This study aimed to identify predictive factors for neoplastic transformation in hyperplastic EGJ lesions.<\/jats:p>\n                  <jats:p>This multicenter, retrospective study included patients with hyperplastic EGJ lesions endoscopically resected across 13 European hospitals. Data were collected from endoscopy and pathology reports. Neoplastic transformation was defined by presence of dysplasia or adenocarcinoma. A multivariable logistic regression model was conducted to assess predictive factors for neoplastic transformation in resected hyperplastic lesions.<\/jats:p>\n                  <jats:p>From January 2015 to October 2024, 91 EGJ hyperplastic lesions were included. Polypectomy\/endoscopic mucosal resection (EMR) was performed in 86% of cases, endoscopic submucosal dissection (ESD) in 19%. En bloc resection was successfully achieved in 93% of cases, whereas R0 resection rates were confirmed in 84% of cases. Twenty-one lesions (23%) showed neoplastic transformation on histology. Independent predictive factors for neoplastic transformation in hyperplastic lesions included non-polypoid morphology (odds ratio [OR] 5.48; P = 0.025), presence of surface ulceration (OR 11.5; P = 0.0005) and lesion size (OR 5.48; P = 0.021). Lesion size &gt; 12 mm was identified as a significant predictor of neoplastic transformation in hyperplastic lesions.<\/jats:p>\n                  <jats:p>EGJ hyperplastic lesions showed a non-negligible risk of neoplastic transformation. These findings highlight the need for careful endoscopic assessment to predict malignancy while promoting appropriate management strategies to ensure adequate R0 resection in case of undetected local malignancy.<\/jats:p>","DOI":"10.1055\/a-2760-6753","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:16:33Z","timestamp":1764634593000},"source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Neoplastic risk in hyperplastic esophagogastric junction lesions: Comprehensive multicenter study"],"prefix":"10.1055","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2818-916X","authenticated-orcid":false,"given":"Elena","family":"De Cristofaro","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery, Gastroenterology, University of Rome Tor Vergata, Rome, Italy"}]},{"given":"Federico","family":"Barbaro","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy"}]},{"given":"J\u00e9r\u00f4me","family":"Rivory","sequence":"additional","affiliation":[{"name":"Gastroenterology, Edouard Herriot Hospital, Lyon, France"}]},{"given":"Alexandru","family":"Lupu","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy, Pavillon L Edouard Herriot Hospital, Lyon, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0803-7903","authenticated-orcid":false,"given":"Benedetto","family":"Neri","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome Tor Vergata, Roma, Italy"},{"name":"Therapeutic GI Endoscopy Unit, Campus Bio-Medico University Hospital, Roma, Italy"}]},{"given":"Dario","family":"Biasutto","sequence":"additional","affiliation":[{"name":"Therapeutic GI Endoscopy Unit, Campus Bio-Medico University Hospital, Roma, Italy"}]},{"given":"Gianluca","family":"Andrisani","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, Campus Bio-Medico University Hospital, Roma, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1293-3353","authenticated-orcid":false,"given":"Rui","family":"Morais","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hospital S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Franscisco","family":"Mendes","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hospital S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-0576","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Santos-Antunes","sequence":"additional","affiliation":[{"name":"Gastroenterology, Hospital S\u00e3o Jo\u00e3o, Porto, Portugal"},{"name":"Glycobiology and Cancer, IPATIMUP, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8758-654X","authenticated-orcid":false,"given":"Germana","family":"de Nucci","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, A.O. Salvini, Garbagnate Milanese (MI), Italy"}]},{"given":"Sandro","family":"Sferrazza","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, Department of Medical and Surgical Sciences, ARNAS Civico Di Cristina Benfratelli, Palermo, Italy"}]},{"given":"Silvia","family":"Pecere","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, Catholic University, Gemelli University Hospital, Rome, Italy"}]},{"given":"Yanis","family":"Dahel","sequence":"additional","affiliation":[{"name":"Endoscopy Unit, Paoli Calmettes Institute, Marseille, France"}]},{"given":"Jean-Philippe","family":"Ratone","sequence":"additional","affiliation":[{"name":"Gastroenterology, Paoli-Camettes, Marseille, France"}]},{"given":"Laura","family":"Rovedatti","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy"}]},{"given":"Cristiano","family":"Spada","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy"}]},{"given":"Francesco Maria","family":"Di Matteo","sequence":"additional","affiliation":[{"name":"Operative Digestive Endoscopy Department, Campus Bio-Medico University Hospital, Roma, Italy"}]},{"given":"Andrea","family":"Anderloni","sequence":"additional","affiliation":[{"name":"Endoscopy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy"}]},{"given":"Philippe","family":"Leclercq","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium"}]},{"given":"Samanta","family":"Romeo","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Department, Maggiore Hospital Crema, Crema, Italy"}]},{"given":"Guido","family":"Manfredi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Department, Maggiore Hospital Crema, Crema, Italy"}]},{"given":"Elisa","family":"Stasi","sequence":"additional","affiliation":[{"name":"Gastroenterology, Digestive Endoscopy, Vito Fazzi Hospital, Lecce, Italy"}]},{"given":"Jeremie","family":"Jacques","sequence":"additional","affiliation":[{"name":"Service d'H\u00e9pato-Gastro-Ent\u00e9rologie, CHU Dupuytren Limoges, Limoges, France"}]},{"given":"Edoardo","family":"Troncone","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5416-6004","authenticated-orcid":false,"given":"Lucile","family":"H\u00e9roin","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology, University Hospitals Strasbourg, Strasbourg, France"}]},{"given":"Jerome","family":"Maitre","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Strasbourg University Hospitals, Strasbourg, France"}]},{"given":"Arthur","family":"Berger","sequence":"additional","affiliation":[{"name":"P\u00f4le H\u00e9pato-Gastro-Ent\u00e9rologie, Diab\u00e9tologie, Nutrition et Endocrinologie, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1797-3864","authenticated-orcid":false,"given":"Giulio","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, Ospedale dei Castelli, Rome, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2912-2792","authenticated-orcid":false,"given":"Simona","family":"Agazzi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy"}]},{"given":"Giovanna","family":"Del Vecchio Blanco","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit, University of Rome Tor Vergata, Rome, Italy"}]},{"given":"Giovanni","family":"Monteleone","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy"}]},{"given":"Mathieu","family":"Pioche","sequence":"additional","affiliation":[{"name":"Gastroenterology, Edouard Herriot Hospital, Lyon, France"}]}],"member":"194","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1007\/BF02087691","article-title":"Esophageal inflammatory fibroid polyp - 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