{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:28:15Z","timestamp":1761514095203,"version":"3.37.3"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["FRH\/BPD\/92394\/2013"],"award-info":[{"award-number":["FRH\/BPD\/92394\/2013"]}]},{"DOI":"10.13039\/501100008530","name":"Fundo Europeu de Desenvolvimento Regional","doi-asserted-by":"crossref","award":["ALENT-07-0224-FEDER-001743"],"award-info":[{"award-number":["ALENT-07-0224-FEDER-001743"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008530","name":"Fundo Europeu de Desenvolvimento Regional","doi-asserted-by":"crossref","award":["ALENT-07-0262-FEDER-001878"],"award-info":[{"award-number":["ALENT-07-0262-FEDER-001878"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"crossref","award":["05\/PICA\/B802\/EC07"],"award-info":[{"award-number":["05\/PICA\/B802\/EC07"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synlett"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>3-Amino-2-oxindole derivatives are a common framework found in many natural products and medicinal compounds and thus their synthesis is of significant importance. We report for the first time a one-pot approach for the synthesis of these compounds, using a bory\u00adlation\/intramolecular asymmetric arylation sequence starting from \u00adortho-bromo-\u03b1-ketimino amide derivatives. Pd(OAc)2 was used as the pre-catalyst along with (R)-BINAP as the chiral source. We successfully obtained a family of 3-phenyl-3-(aryl-amino)-indolin-2-one derivatives (11 in total) with excellent yields (up to 98%) and enantioselectivities of up to 76% ee. The reaction is versatile and tolerant of a wide range of functional groups.<\/jats:p>","DOI":"10.1055\/s-0036-1590940","type":"journal-article","created":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T19:44:44Z","timestamp":1509738284000},"page":"497-502","source":"Crossref","is-referenced-by-count":5,"title":["Pd-Catalyzed One-Pot Borylation\/Intramolecular Asymmetric Arylation on \u03b1-Ketiminoamides: Innovative Approach to Chiral 3-Amino-2-oxindoles"],"prefix":"10.1055","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1697-7871","authenticated-orcid":false,"given":"Carolina","family":"Marques","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica de \u00c9vora, University of \u00c9vora, Institute for Research and Advanced Training, CLAV"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8248-1116","authenticated-orcid":false,"given":"Anthony","family":"Burke","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica de \u00c9vora, University of \u00c9vora, Institute for Research and Advanced Training, CLAV"},{"name":"Department of Chemistry, School of Science and Technology, University of \u00c9vora, CLAV"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9430-7983","authenticated-orcid":false,"given":"Simon","family":"Lawrence","sequence":"additional","affiliation":[{"name":"School of Chemistry, Analytical and Biological Chemistry Research Facility, Solid State Pharmaceutical Centre, University College Cork"}]}],"member":"194","published-online":{"date-parts":[[2017,11,3]]},"container-title":["Synlett"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0036-1590940.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T18:46:27Z","timestamp":1518720387000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0036-1590940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,3]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2018,2,15]]},"published-print":{"date-parts":[[2018,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0036-1590940","relation":{},"ISSN":["0936-5214","1437-2096"],"issn-type":[{"type":"print","value":"0936-5214"},{"type":"electronic","value":"1437-2096"}],"subject":[],"published":{"date-parts":[[2017,11,3]]}}}