{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:17:18Z","timestamp":1758637038837,"version":"3.37.3"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synthesis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>Diastereoselective Diels\u2013Alder reactions of 2,6-diaryl-1,2-dihydropyridines with N-methylmaleimide afford highly substituted isoquinuclidines in good chemical yield (30\u201350%). This sequential one-pot synthesis is performed under microwave irradiation and involves, primarily, the synthesis of 2,6-diaryl-1,2-dihydropyridines by a 6\u03c0-azaelectrocyclisation involving an intermediate \u03b1,\u03b2,\u03b3,\u03b4-di-unsaturated imine, obtained by condensation of (E,E)-cinnamylideneacetophenones with amines. This procedure easily converts unstable 2,6-diaryl-1,2-dihydropyridines into, otherwise inaccessible, isoquinuclidines without any kind of manipulation.<\/jats:p>","DOI":"10.1055\/s-0036-1591767","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T18:44:56Z","timestamp":1520448296000},"page":"1965-1972","source":"Crossref","is-referenced-by-count":5,"title":["One-Pot Synthesis of Isoquinuclidines via 2,6-Diaryl-1,2-dihydropyridines using (E,E)-Cinnamylideneacetophenones as Templates"],"prefix":"10.1055","volume":"50","author":[{"given":"Pedro","family":"Varandas","sequence":"additional","affiliation":[{"name":"QOPNA, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago"}]},{"given":"Djenisa","family":"Rocha","sequence":"additional","affiliation":[{"name":"QOPNA, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago"}]},{"given":"Filipe","family":"Paz","sequence":"additional","affiliation":[{"name":"CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro"}]},{"given":"Eduarda","family":"Silva","sequence":"additional","affiliation":[{"name":"QOPNA, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago"},{"name":"UCIBIO, REQUIMTE, Department of Chemistry Sciences, Facultyof Pharmacy, University of Porto"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":false,"given":"Artur","family":"Silva","sequence":"additional","affiliation":[{"name":"QOPNA, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago"}]}],"member":"194","published-online":{"date-parts":[[2018,3,7]]},"container-title":["Synthesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0036-1591767.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T11:19:01Z","timestamp":1557832741000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0036-1591767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,7]]},"references-count":0,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,4,27]]},"published-print":{"date-parts":[[2018,5]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0036-1591767","relation":{},"ISSN":["0039-7881","1437-210X"],"issn-type":[{"type":"print","value":"0039-7881"},{"type":"electronic","value":"1437-210X"}],"subject":[],"published":{"date-parts":[[2018,3,7]]}}}