{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:43:49Z","timestamp":1762674229517,"version":"3.37.3"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synlett"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>We report an efficient one-pot synthesis of a novel series of chromenopyridodiazepinone polyheterocycles by a catalyst-free nucleo\u00adphilic addition of ethane-1,2-diamine to (E,E)-3-[3-(2-hydroxyphenyl)-3-oxoprop-1-en-1-yl]-2-styrylchromones at room temperature under mild conditions. The reaction proceeds by a tandem process involving 1,4- and 1,6-aza-conjugate additions of one amino group of ethane-1,2-diamine to the \u03b1,\u03b2-unsaturated (3-oxoprop-1-en-1-yl) and the \u03b1,\u03b2,\u03b3,\u03b4-diunsaturated (2-styrylchromone) carbonyl system of the precursor, followed by imine condensation of the remaining amino group to generate the chromenopyridodiazepinone polyheterocycle. All compounds were characterized by means of one- and two-dimensional NMR spectroscopy and single-crystal X-ray crystallography.<\/jats:p>","DOI":"10.1055\/s-0037-1609201","type":"journal-article","created":{"date-parts":[[2018,1,30]],"date-time":"2018-01-30T18:37:51Z","timestamp":1517337471000},"page":"885-889","source":"Crossref","is-referenced-by-count":3,"title":["Diastereoselective One-Pot Tandem Synthesis of Chromenopyridodiazepinones through 1,4- and 1,6-Aza-Conjugate Additions\/Heterocyclizations"],"prefix":"10.1055","volume":"29","author":[{"given":"Oualid","family":"Talhi","sequence":"first","affiliation":[{"name":"Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques (CRAPC)"},{"name":"QOPNA and Department of Chemistry, University of Aveiro"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":false,"given":"Artur","family":"Silva","sequence":"first","affiliation":[{"name":"QOPNA and Department of Chemistry, University of Aveiro"}]},{"given":"Abdelghani","family":"Bouchama","sequence":"additional","affiliation":[{"name":"Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques (CRAPC)"},{"name":"Laboratoire de Structure, Elaboration et Application des Mat\u00e9riaux Mol\u00e9culaires (SEA2M), Facult\u00e9 des Sciences et de la Technologie, BP 188, Universit\u00e9 Abdelhamid Benbadis"}]},{"given":"Ridha","family":"Hassaine","sequence":"additional","affiliation":[{"name":"Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques (CRAPC)"},{"name":"Laboratoire de Catalyse et Synth\u00e8se en Chimie Organique, Facult\u00e9 des Sciences, Universit\u00e9 de Tlemcen"}]},{"given":"Nadia","family":"Taibi","sequence":"additional","affiliation":[{"name":"Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques (CRAPC)"}]},{"given":"Ricardo","family":"Mendes","sequence":"additional","affiliation":[{"name":"CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro"}]},{"given":"Fillipe","family":"Almeida Paz","sequence":"additional","affiliation":[{"name":"CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro"}]},{"given":"Khaldoun","family":"Bachari","sequence":"additional","affiliation":[{"name":"Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques (CRAPC)"}]}],"member":"194","published-online":{"date-parts":[[2018,1,30]]},"container-title":["Synlett"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1609201.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T18:46:31Z","timestamp":1523472391000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1609201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,30]]},"references-count":0,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2018,4,11]]},"published-print":{"date-parts":[[2018,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1609201","relation":{},"ISSN":["0936-5214","1437-2096"],"issn-type":[{"type":"print","value":"0936-5214"},{"type":"electronic","value":"1437-2096"}],"subject":[],"published":{"date-parts":[[2018,1,30]]}}}