{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:00:25Z","timestamp":1775080825579,"version":"3.50.1"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"name":"FEDER - Operational Competitiveness and Internationalization Program","award":["NORTE-01-0145-FEDER-000011"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000011"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PT-DZ\/0005, FCTUID\/QUI\/00062\/2013"],"award-info":[{"award-number":["PT-DZ\/0005, FCTUID\/QUI\/00062\/2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synthesis"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>The Diels\u2013Alder reaction of 1,2-dihydropyridines with different dienophiles is a well-established and straightforward method for the synthesis of isoquinuclidines. Nevertheless, the enantioselective preparation of isoquinuclidines using organocatalysts or organometallic catalysts is rather unexplored. This succinct review offers readers an overall perspective of the most important recent developments and concepts related to this topic.<\/jats:p><jats:p>1 \tIntroduction<\/jats:p><jats:p>2 \tAsymmetric Diels\u2013Alder Reaction of 1,2-Dihydropyridines<\/jats:p><jats:p>2.1 \tTransition-Metal-Catalyzed Reactions<\/jats:p><jats:p>2.2 \tOrganocatalyzed Reactions<\/jats:p><jats:p>3 \tDiels\u2013Alder Reaction of 1,2-Dihydropyridines in the Synthesis of Biologically Valuable Compounds<\/jats:p><jats:p>4 \tConclusion<\/jats:p>","DOI":"10.1055\/s-0037-1609418","type":"journal-article","created":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T18:49:01Z","timestamp":1522867741000},"page":"1773-1782","source":"Crossref","is-referenced-by-count":31,"title":["Diels\u2013Alder Reactions of 1,2-Dihydropyridines: An Efficient Tool for the Synthesis of Isoquinuclidines"],"prefix":"10.1055","volume":"50","author":[{"given":"Eduarda","family":"Silva","sequence":"first","affiliation":[{"name":"LAQV, REQUIMTE, Department of Chemistry Sciences, Faculty of Pharmacy, University of Porto"},{"name":"QOPNA, Department of Chemistry, University of Aveiro"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-8286","authenticated-orcid":false,"given":"Artur","family":"Silva","sequence":"first","affiliation":[{"name":"QOPNA, Department of Chemistry, University of Aveiro"}]},{"given":"Djenisa","family":"Rocha","sequence":"additional","affiliation":[{"name":"QOPNA, Department of Chemistry, University of Aveiro"}]}],"member":"194","published-online":{"date-parts":[[2018,4,4]]},"container-title":["Synthesis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0037-1609418.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,4,18]],"date-time":"2018-04-18T19:41:51Z","timestamp":1524080511000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0037-1609418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,4]]},"references-count":0,"journal-issue":{"issue":"09","published-online":{"date-parts":[[2018,4,18]]},"published-print":{"date-parts":[[2018,5]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0037-1609418","relation":{},"ISSN":["0039-7881","1437-210X"],"issn-type":[{"value":"0039-7881","type":"print"},{"value":"1437-210X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,4]]}}}