{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T10:27:48Z","timestamp":1747391268872},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Otorhinolaryngol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:p>\n            Introduction\u2003Hypopharyngeal tumors are head and neck malignancies associated with a great mortality rate, and the treatment of advanced lesions constitutes a challenging problem. Pharyngolaryngectomy continues to be the gold standard treatment modality for locally-advanced diseases, and it is currently used as the primary treatment or in cases of relapse after an organ preservation strategy.<\/jats:p><jats:p>\n            Objective\u2003This study aims to compare the survival rates of patients with advanced hypopharyngeal tumors treated with pharyngolaryngectomy as a primary or salvage option, and identify possible prognostic factors.<\/jats:p><jats:p>\n            Methods\u2003All patients with advanced hypopharyngeal squamous cell carcinomas who performed pharyngolaryngectomy between 2007 and 2014 were reviewed retrospectively.<\/jats:p><jats:p>\n            Results\u2003A total of 87 patients fulfilled the aforementioned criteria, and the sample had a mean age of 57.2 years and a male predominance of 43:1. The tumors were located in the pyriform sinus walls (81 tumors), in the posterior pharyngeal wall (4 tumors) and in the postcricoid region (2 tumors). A total of 60 patients underwent surgery as the primary treatment option, and 27 were submitted to salvage pharyngolaryngectomy after a previous treatment with chemoradiotherapy or radiotherapy. The 5-year overall survival was of 25.9%, the 5-year disease-free survival was of 24.2%, and the disease-specific survival was of 29.5%.<\/jats:p><jats:p>\n            Conclusion\u2003The patients treated with pharyngolaryngectomy as the primary option revealed a better 5-year-disease free survival than the patients who underwent the salvage surgery (35.8% versus 11.7% respectively; p\u2009&lt;\u20090.05). The histopathological criteria of capsular rupture of the lymph nodes (30.1% versus 19.8% respectively for the primary and salvage groups; p\u2009&lt;\u20090.05) and vascular invasion (30.5% versus 22.5% respectively; p\u2009&lt;\u20090.05) reduced the 5-year disease-free survival. Pharyngolaryngectomy as the primary intent revealed a lower local recurrence rate than the salvage surgery (40.6% versus 83.3% respectively; p\u2009&lt;\u20090.05).<\/jats:p>","DOI":"10.1055\/s-0038-1641562","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T23:08:47Z","timestamp":1530832127000},"page":"443-448","source":"Crossref","is-referenced-by-count":9,"title":["Surgically-Treated Locoregionally Advanced Hypopharyngeal Cancer: Outcomes"],"prefix":"10.1055","volume":"22","author":[{"given":"Jorge","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaringology, Hospital da Senhora da Oliveira Guimar\u00e3es EPE, Creixomil, Guimar\u00e3es, Portugal"},{"name":"Department of Anatomy, University of Porto, Portugal"}]},{"given":"Eduardo","family":"Breda","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaringology, Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil EPE, Porto, Portugal"}]},{"given":"Eurico","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaringology, Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil EPE, Porto, Portugal"}]}],"member":"194","published-online":{"date-parts":[[2018,7,5]]},"container-title":["International Archives of Otorhinolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0038-1641562.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T21:11:02Z","timestamp":1557177062000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0038-1641562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,5]]},"references-count":0,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2018,10,22]]},"published-print":{"date-parts":[[2018,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0038-1641562","relation":{},"ISSN":["1809-9777","1809-4864"],"issn-type":[{"value":"1809-9777","type":"print"},{"value":"1809-4864","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,5]]}}}