{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:34:59Z","timestamp":1761514499404,"version":"3.37.3"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["PD\/BD\/143159\/2019"],"award-info":[{"award-number":["PD\/BD\/143159\/2019"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["Pest-OE\/QUI\/UI0619\/2019"],"award-info":[{"award-number":["Pest-OE\/QUI\/UI0619\/2019"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["SFRH\/BD\/130198\/2017"],"award-info":[{"award-number":["SFRH\/BD\/130198\/2017"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UID\/QUI\/00313\/2019"],"award-info":[{"award-number":["UID\/QUI\/00313\/2019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synlett"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>A successful one-pot methodology for the synthesis of chiral 2-tetrazolyl-2H-azirines has been established, resorting to organocatalysis. The protocol involves the in situ tosylation of \u03b2-ketoxime-1H-tetrazoles followed by the Neber reaction, in the presence of chiral organocatalysts. Among the organocatalysts studied a novel thiourea catalyst derived from 6\u03b2-aminopenicillanic acid afforded excellent enantioselectivities.<\/jats:p>","DOI":"10.1055\/s-0039-1691533","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T23:50:15Z","timestamp":1576626615000},"page":"553-558","source":"Crossref","is-referenced-by-count":11,"title":["Asymmetric Neber Reaction in the Synthesis of Chiral 2-(Tetrazol-5-yl)-2H-Azirines"],"prefix":"10.1055","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1886-6112","authenticated-orcid":false,"given":"Cl\u00e1udia","family":"Alves","sequence":"additional","affiliation":[{"name":"CQC and Department of Chemistry, University of Coimbra, 3004-535 Coimbra"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1999-3471","authenticated-orcid":false,"given":"Carla","family":"Grosso","sequence":"additional","affiliation":[{"name":"CQC and Department of Chemistry, University of Coimbra, 3004-535 Coimbra"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4075-3667","authenticated-orcid":false,"given":"Pedro","family":"Barrulas","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica de \u00c9vora and Department of Chemistry, University of \u00c9vora"},{"name":"HERCULES Laboratory, \u00c9vora University"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4634-7395","authenticated-orcid":false,"given":"Jos\u00e9 A.","family":"Paix\u00e3o","sequence":"additional","affiliation":[{"name":"CFisUC and Department of Physics, University of Coimbra"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0551-7255","authenticated-orcid":false,"given":"Ana L.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"CQC and Department of Chemistry, University of Coimbra, 3004-535 Coimbra"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8248-1116","authenticated-orcid":false,"given":"Anthony J.","family":"Burke","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica de \u00c9vora and Department of Chemistry, University of \u00c9vora"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9588-4555","authenticated-orcid":false,"given":"Am\u00e9rico","family":"Lemos","sequence":"additional","affiliation":[{"name":"CQC and Department of Chemistry, University of Coimbra, 3004-535 Coimbra"},{"name":"FCT, University of Algarve"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3256-4954","authenticated-orcid":false,"given":"Teresa M. V. D.","family":"Pinho e Melo","sequence":"additional","affiliation":[{"name":"CQC and Department of Chemistry, University of Coimbra, 3004-535 Coimbra"}]}],"member":"194","published-online":{"date-parts":[[2019,12,17]]},"container-title":["Synlett"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0039-1691533.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T23:42:22Z","timestamp":1584402142000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0039-1691533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,17]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2020,3,16]]},"published-print":{"date-parts":[[2020,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0039-1691533","relation":{},"ISSN":["0936-5214","1437-2096"],"issn-type":[{"type":"print","value":"0936-5214"},{"type":"electronic","value":"1437-2096"}],"subject":[],"published":{"date-parts":[[2019,12,17]]}}}