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These new hybrids contain a 1,4-disubstituted 1,2,3-triazole ring at the 3-OH position of quercetin whilst the remaining hydroxyl groups were either protected as methyl or benzyl groups or left unprotected. All the quercetin-1,2,3-triazole hybrids I\u2013IV were evaluated against REM-134 canine mammary cancer cell line, which is used as a translational model for human breast cancer. These new analogues exhibit potent antiproliferative activity against this cancer cell line. Furthermore, the results show that some of the new quercetin-1,2,3-triazole hybrids have better activity than quercetin. Our best inhibitors displayed IC50 values in the range of 41\u2013180 nM, and undoubtedly will have an important impact on the treatment of both canine and human breast cancer.<\/jats:p>","DOI":"10.1055\/s-0040-1719928","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T22:42:49Z","timestamp":1654728169000},"page":"4272-4284","source":"Crossref","is-referenced-by-count":9,"title":["Synthesis and Antiproliferative Activity of Novel Quercetin-1,2,3-Triazole Hybrids using the 1,3-Dipolar Cycloaddition (Click) Reaction"],"prefix":"10.1055","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8117-7737","authenticated-orcid":false,"given":"Elisabete P.","family":"Carreiro","sequence":"first","affiliation":[{"name":"University of \u00c9vora, Institute of Research and Advanced Training, LAQV-REQUIMTE"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4077-9755","authenticated-orcid":false,"given":"Carlos M.","family":"Gastalho","sequence":"additional","affiliation":[{"name":"University of \u00c9vora, School of Science and Technology, Department of Chemistry and Biochemistry"},{"name":"University of \u00c9vora, School of Health and Human Development, Department of Medical and Health Sciences"}]},{"given":"Sofia","family":"Ernesto","sequence":"additional","affiliation":[{"name":"University of \u00c9vora, School of Science and Technology, Department of Chemistry and Biochemistry"}]},{"given":"Ana R.","family":"Costa","sequence":"additional","affiliation":[{"name":"University of \u00c9vora, School of Health and Human Development, Department of Medical and Health Sciences"},{"name":"University of \u00c9vora, Institute of Research and Advanced Training, Institute of Earth Sciences"}]},{"given":"C\u00e9lia M.","family":"Antunes","sequence":"additional","affiliation":[{"name":"University of \u00c9vora, School of Health and Human Development, Department of Medical and Health Sciences"},{"name":"University of \u00c9vora, Institute of Research and Advanced Training, Institute of Earth Sciences"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8248-1116","authenticated-orcid":false,"given":"Anthony J.","family":"Burke","sequence":"additional","affiliation":[{"name":"University of \u00c9vora, Institute of Research and Advanced Training, LAQV-REQUIMTE"},{"name":"University of \u00c9vora, School of Science and Technology, Department of Chemistry and Biochemistry"}]}],"member":"194","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"109604","DOI":"10.1016\/j.biopha.2019.109604","volume":"121","author":"S.-M Tang","year":"2020","journal-title":"Biomed. 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