{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:15:24Z","timestamp":1777364124915,"version":"3.51.4"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"11","funder":[{"name":"11\u00b0 Bolsa de Investiga\u00e7\u00e3o Funda\u00e7\u00e3o AstraZeneca - Faculdade de Medicina Universidade de Lisboa"},{"name":"D. Manuel de Mello grant"},{"DOI":"10.13039\/100017252","name":"Funda\u00e7\u00e3o Am\u00e9lia de Mello","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100017252","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o para Ci\u00eancia e Tecnologia","award":["SFRH\/SINTD\/92677\/2013"],"award-info":[{"award-number":["SFRH\/SINTD\/92677\/2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Elucidating mechanisms of brain damage in cerebral venous thrombosis (CVT) would be instrumental to develop targeted therapies and improve prognosis prediction. Matrix metalloproteinase-9 (MMP-9), a gelatinase that degrades major components of the basal lamina, has been associated to blood\u2013brain barrier disruption. We aimed to assess, in patients with CVT, the temporal change in serum concentrations of MMP-9 and its association with key imaging and clinical outcomes.<\/jats:p><jats:p>\n          Methods\u2003Pathophysiology of Venous Infarction\u2014PRediction of InfarctiOn and RecanalIzaTion in CVT (PRIORITy-CVT) was a multicenter prospective cohort study of patients with newly diagnosed CVT. Serial collection of peripheral blood samples performed on day 1, 3, and 8, and standardized magnetic resonance imaging on day 1, 8, and 90. MMP-9 was quantified using enzyme-linked immunosorbent assay in 59 patients and 22 healthy controls. Primary outcomes were parenchymal brain lesion, early evolution of brain lesion, early recanalization, and functional outcome on day 90.<\/jats:p><jats:p>\n          Results\u2003CVT patients with parenchymal brain lesion had higher baseline concentrations of MMP-9 compared with controls (adjusted p\u2009=\u20090.001). The area under receiver operating characteristic curve value for MMP-9 for predicting brain lesion was 0.71 (95% confidence interval [CI]: 0.57\u20130.85, p\u2009=\u20090.009). Patients with venous recanalization showed early decline of circulating MMP-9 and significantly lower levels on day 8 (p\u2009=\u20090.021). Higher MMP-9 on day 8 was associated with persistent venous occlusion (odds ratio: 1.20 [per 20\u2009ng\/mL], 95% CI: 1.02\u20131.43, p\u2009=\u20090.030).<\/jats:p><jats:p>\n          Conclusion\u2003We report a novel relationship among MMP-9, parenchymal brain damage, and early venous recanalization, suggesting that circulating MMP-9 is a dynamic marker of brain tissue damage in patients with CVT.<\/jats:p>","DOI":"10.1055\/s-0041-1726094","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:07:46Z","timestamp":1616544466000},"page":"1476-1482","source":"Crossref","is-referenced-by-count":14,"title":["Matrix Metalloproteinase-9 Levels are Associated with Brain Lesion and Persistent Venous Occlusion in Patients with Cerebral Venous Thrombosis"],"prefix":"10.1055","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6702-7924","authenticated-orcid":false,"given":"Diana","family":"Aguiar de Sousa","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria\/CHULN, Universidade de Lisboa, Lisbon, Portugal"},{"name":"Institute of Anatomy, Faculdade de Medicina, University of Lisbon, Lisbon, Portugal"},{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Maria Concei\u00e7\u00e3o","family":"Pereira-Santos","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Ana","family":"Serra-Caetano","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Lia Lucas","family":"Neto","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, Faculdade de Medicina, University of Lisbon, Lisbon, Portugal"},{"name":"Department of Neuroradiology, Hospital de Santa Maria - CHULN, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Ana Lu\u00edsa","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospitalar de Entre Douro e Vouga, Santa Maria da Feira, Portugal"}]},{"given":"Denis","family":"Gabriel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospitalar Universit\u00e1rio do Porto - Hospital Santo Ant\u00f3nio, Porto, Portugal"}]},{"given":"Manuel","family":"Correia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospitalar Universit\u00e1rio do Porto - Hospital Santo Ant\u00f3nio, Porto, Portugal"}]},{"given":"Raquel","family":"Gil-Gouveia","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital da Luz, Lisbon, Portugal"}]},{"given":"Renato","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hospital da Luz, Lisbon, Portugal"}]},{"given":"Sara","family":"Penas","sequence":"additional","affiliation":[{"name":"Institute of Anatomy, Faculdade de Medicina, University of Lisbon, Lisbon, Portugal"}]},{"given":"Mariana","family":"Carvalho Dias","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria\/CHULN, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Manuel A.","family":"Correia","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Hospital de Santa Maria - CHULN, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Marta","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o, Faculty of Medicine, University of Porto, Porto, Portugal"}]},{"given":"Ana E.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Patr\u00edcia","family":"Canh\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria\/CHULN, Universidade de Lisboa, Lisbon, Portugal"},{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal"}]},{"given":"Jos\u00e9 M.","family":"Ferro","sequence":"additional","affiliation":[{"name":"Department of Neurosciences and Mental Health (Neurology), Hospital de Santa Maria\/CHULN, Universidade de Lisboa, Lisbon, Portugal"},{"name":"Instituto de Medicina Molecular Jo\u00e3o Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, 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