{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:43:37Z","timestamp":1740167017139,"version":"3.37.3"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Coloproctology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Background\u2003Anatomopathological staging is the primary method to determine the prognosis of patients with colorectal carcinoma (CRC). However, new tools have been developed that can complement it, such as the analysis of the elevation of systemic inflammatory markers.<\/jats:p><jats:p>Objective\u2003To evaluate the impact of the elevation of scores based on inflammatory markers (the neutrophil-to-lymphocyte ratio [NLR], the Glasgow Prognostic Score [GPS], and isolated C-reactive protein [CRP]) in the prognosis of patients diagnosed with CRC and submitted to potentially curative surgery in Hospital de Braga, Portugal, between January 1st, 2005, and December 31st, 2010.<\/jats:p><jats:p>Methods\u2003A retrospective analysis of the data of 426 patients was performed, with a collection of several clinico-pathological variables, as well as the levels of lymphocytes, neutrophils, albumin and CRP, in the pre- and postoperative periods, to apply the different scores to the sample.<\/jats:p><jats:p>Results\u2003From the analysis of the survival curves, we concluded that patients with increased NLR in the pre- and postoperative periods present a lower cancer-related survival than patients with normal NLR (preoperative period: 93.7 versus 122 months; p\u2009&lt;\u20090.001; postoperative period: 112 versus 131 months; p\u2009=\u20090.002). Patients with increased NLR in the pre- and postoperative periods also had a lower disease-free survival (preoperative period: 88.0 versus 122 months; p\u2009&lt;\u20090.001; postoperative period: 111 versus 132 months; p\u2009=\u20090.002). In addition, increased pre- and postoperative NLR was associated with a higher risk of death due to CRC (preoperatively: hazard ratio [HR]\u2009=\u20092.25; p\u2009&lt;\u20090.001; postoperatively: HR\u2009=\u20092.18; p\u2009=\u20090.003). However, the multivariate analysis shows that only postoperative NLR (ajusted HR\u2009=\u20092.66; p\u2009=\u20090.002) does so independently of the remaining variables.<\/jats:p><jats:p>Conclusion\u2003Regarding the scores applied to the sample, the NLR was the one that most consistently related to the prognosis of the patients. However, it would be useful to develop a prospective study that could confirm this relationship.<\/jats:p>","DOI":"10.1055\/s-0041-1735458","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T10:08:20Z","timestamp":1644228500000},"page":"393-405","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Inflammation-based Prognostic Scores in Patients with Colorectal Cancer"],"prefix":"10.1055","volume":"41","author":[{"given":"Jo\u00e3o Pedro Lima","family":"Afonso","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), Escola de Medicina, Universidade do Minho, Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1374-1372","authenticated-orcid":false,"given":"Ana","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of General Surgery , Hospital de Braga, Braga, Portugal"}]},{"given":"Joaquim Costa","family":"Pereira","sequence":"additional","affiliation":[{"name":"Coloproctology Unit, Department of General Surgery, Hospital de Braga, Braga, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3526-3199","authenticated-orcid":false,"given":"Sandra F.","family":"Martins","sequence":"additional","affiliation":[{"name":"Life and Health Sciences Research Institute (ICVS), Escola de Medicina, Universidade do Minho, Braga, Portugal"},{"name":"Coloproctology Unit, Department of General Surgery, Hospital de Braga, Braga, Portugal"},{"name":"Life and Health Sciences Research Institute\/Biomaterials, Biodegradables and Biomimetics (ICVS\/3B's)\u2013 Associate Laboratory, Braga\/Guimar\u00e3es, Braga, Portugal"}]}],"member":"194","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"issue":"08","key":"ref1","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/jso.21864","article-title":"Predictors of cure after hepatic resection of colorectal liver metastases: an analysis of actual 5- and 10-year survivors","volume":"103","author":"T C Chua","year":"2011","journal-title":"J Surg Oncol"},{"issue":"12","key":"ref2","first-page":"5567","article-title":"Prognostic value of preoperative inflammation-based prognostic scores in patients with stage IV colorectal cancer who undergo palliative resection of asymptomatic primary tumors","volume":"33","author":"K Maeda","year":"2013","journal-title":"Anticancer Res"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1159\/000346002","article-title":"Glasgow prognostic score as a prognostic factor in patients undergoing curative surgery for colorectal cancer","volume":"29","author":"K Sugimoto","year":"2012","journal-title":"Dig Surg"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1097\/SLA.0b013e3181454171","article-title":"Inflammation-based prognostic score is a novel predictor of postoperative outcome in patients with colorectal cancer","volume":"246","author":"M Ishizuka","year":"2007","journal-title":"Ann Surg"},{"issue":"08","key":"ref5","first-page":"3291","article-title":"A high preoperative neutrophil-to-lymphocyte ratio is associated with poor survival in patients with colorectal cancer","volume":"33","author":"M Shibutani","year":"2013","journal-title":"Anticancer Res"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00384-012-1459-x","article-title":"Can neutrophil-to-lymphocyte ratio predict the survival of colorectal cancer patients who have received curative surgery electively?","volume":"27","author":"S F Chiang","year":"2012","journal-title":"Int J Colorectal Dis"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00042737-200304000-00006","article-title":"Serum C-reactive protein correlates with survival in colorectal cancer patients but is not an independent prognostic indicator","volume":"15","author":"Y C Chung","year":"2003","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1158\/1538-7445.AM2013-102","article-title":"Abstract 102: Circulating C-reactive protein and colorectal cancer risk: a report from the Shanghai Men's Health Study","volume":"73","author":"J Wu","year":"2013","journal-title":"Cancer Res"},{"issue":"08","key":"ref9","doi-asserted-by":"crossref","first-page":"689","DOI":"10.7150\/jca.9569","article-title":"The modified glasgow prognostic score is an independent prognostic factor in patients with inoperable thoracic esophageal squamous cell carcinoma undergoing chemoradiotherapy","volume":"5","author":"P Zhang","year":"2014","journal-title":"J Cancer"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.5489\/cuaj.3587","article-title":"The neutrophil-to-lymphocyte ratio in clinical practice","volume":"10","author":"A G\u00fcra\u011fa\u00e7","year":"2016","journal-title":"Can Urol Assoc J"},{"issue":"05","key":"ref11","first-page":"602","article-title":"[An elevated neutrophil\/lymphocyte ratio is associated with poor prognosis in stage II resected colon cancer]","volume":"141","author":"G I Urrejola","year":"2013","journal-title":"Rev Med Chil"},{"issue":"06","key":"ref12","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1634\/theoncologist.8-6-541","article-title":"Cancer survival and incidence from the Surveillance, Epidemiology, and End Results (SEER) program","volume":"8","author":"L A Gloeckler Ries","year":"2003","journal-title":"Oncologist"},{"issue":"09","key":"ref13","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/apt.12682","article-title":"Systematic review with meta-analysis: the incidence of advanced neoplasia after polypectomy in patients with and without low-risk adenomas","volume":"39","author":"C Hassan","year":"2014","journal-title":"Aliment Pharmacol Ther"},{"issue":"05","key":"ref14","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"J Ferlay","year":"2015","journal-title":"Int J Cancer"},{"issue":"07","key":"ref15","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.3748\/wjg.v9.i7.1598","article-title":"Meta analysis of risk factors for colorectal cancer","volume":"9","author":"K Chen","year":"2003","journal-title":"World J Gastroenterol"},{"issue":"22","key":"ref16","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1001\/jama.290.22.2959","article-title":"Risk factors for advanced colonic neoplasia and hyperplastic polyps in asymptomatic individuals","volume":"290","author":"D A Lieberman","year":"2003","journal-title":"JAMA"},{"issue":"03","key":"ref17","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/15398285.2012.701177","article-title":"Cancer Facts & Figures 2017. American Cancer Society (ACS)","volume":"16","author":"T Tarver","year":"2017","journal-title":"J Consum Health Internet"},{"issue":"01","key":"ref18","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1186\/1471-2407-10-688","article-title":"Tumor location and patient characteristics of colon and rectal adenocarcinomas in relation to survival and TNM classes","volume":"10","author":"K Hemminki","year":"2010","journal-title":"BMC Cancer"},{"issue":"01","key":"ref19","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejca.2008.08.019","article-title":"Evaluation of the prognostic value of systemic inflammation and socioeconomic deprivation in patients with resectable colorectal liver metastases","volume":"45","author":"C P Neal","year":"2009","journal-title":"Eur J Cancer"},{"issue":"06","key":"ref20","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1053\/j.gastro.2010.01.058","article-title":"Inflammation and colon cancer","volume":"138","author":"J 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