{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:43:36Z","timestamp":1740167016766,"version":"3.37.3"},"reference-count":59,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Coloproctology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003The gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. Even though it can be found in any location of the digestive tract, the colorectal GIST is rare. With this study, we aim to review the current knowledge regarding the prognosis and management of colorectal GIST.<\/jats:p><jats:p>\n          Methods\u2003A literature search was conducted in PubMed, and 717 articles were collected. After analyzing these studies, 60 articles were selected to use in this review.<\/jats:p><jats:p>\n          Results\u2003The mitotic index, as well as tumor size and location were identified as good discriminators of prognosis in various studies. Surgery remains the only curative therapy for potentially resectable tumors. However, even after surgical resection, some patients develop disease recurrence and metastasis, especially those with high-risk tumors. Therefore, surgical resection alone might be inadequate for the management of all colorectal GISTs. The discovery of GIST's molecular pathway led to a shift in its therapy, insofar as tyrosine kinase inhibitors became part of the treatment schemes for this tumor, revolutionizing the treatment's outcome and prognosis.<\/jats:p><jats:p>\n          Discussion\/Conclusion\u2003The controversy concerning colorectal GIST prognosis and treatment can be, in part, attributed to the limited number of studies in the literature. In this review, we gathered the most recent knowledge about the prognosis and management of GIST in this rare location and propose two algorithms for its approach. Lastly, we highlight the importance of an individualized approach in the setting of a multidisciplinary team.<\/jats:p>","DOI":"10.1055\/s-0041-1740297","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T20:17:51Z","timestamp":1644005871000},"page":"068-076","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Factors and Management of Colorectal Gastrointestinal Stromal Tumors"],"prefix":"10.1055","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6638-8293","authenticated-orcid":false,"given":"Nuno Rafael Pereira","family":"Reis","sequence":"additional","affiliation":[{"name":"Department of Surgery and Physiology, Faculdade de Medicina, Universidade do Porto, Porto, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6974-5751","authenticated-orcid":false,"given":"Laura Elisabete Ribeiro","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Surgery and Physiology, Faculdade de Medicina, Universidade do Porto, Porto, Portugal."},{"name":"Department of General Surgery, Centro Hospitalar Universit\u00e1rio S\u00e3o Jo\u00e3o, Servi\u00e7o de Cirurgia Geral, Porto, Portugal."}]}],"member":"194","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"issue":"20","key":"ref1","doi-asserted-by":"publisher","first-page":"3110","DOI":"10.1002\/cncr.30239","article-title":"Diagnostic and treatment strategy for small gastrointestinal stromal tumors","volume":"122","author":"T Nishida","year":"2016","journal-title":"Cancer"},{"issue":"05","key":"ref2","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s00423-018-1683-0","article-title":"Predictors of lymph node metastasis in patients with gastrointestinal stromal tumors (GISTs)","volume":"403","author":"A Gaitanidis","year":"2018","journal-title":"Langenbecks Arch Surg"},{"issue":"03","key":"ref3","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.suc.2017.01.011","article-title":"Atypical 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