{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T06:50:24Z","timestamp":1751957424854},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\nTo determine the prevalence of hypogonadotropic hypogonadism (HH) among patients with non-functioning pituitary adenomas (NFPA) and the post-surgery outcome on pituitary gonadotropins secretion (PGS); to determine the prevalence of erectile dysfunction (ED) on male patients with NFPA, to evaluate the impact of testosterone replacement therapy (TRT) in those with HH.<\/jats:p><jats:p>\nRetrospective evaluation of gonadal function in 109 NFPA patients (45 males), with a mean age of 51.8 years, diagnosed on the last 10 years. ED questionnaire applied to 34 male patients.<\/jats:p><jats:p>\nMale patients with NFPA were significantly older (males 58.1\u00b115.8 vs. females 47.4\u00b116.94; p=0.001). Most patients had macroadenomas (67%; p=0.001) and only a minority were incidentalomas (19%; p&lt;0.001). Prevalence of HH was 40% (60% on males, 25% on females; p&lt;0.001). Surgery was performed in 54% of all patients (71% of males, 42% of females; p&lt;0.003). After intervention, 14% became HH, 69% maintained previous function and 17% improved. On the questionnaire, 76% reported having ED, 54% of which had HH and 21% were under TRT. Of the patients under TRT, 79% still had ED. Median age of patients with ED was significantly higher [with ED 65 vs. without 49 years; p=0.012). There was no BMI difference between patients with or without TRT (28.0 vs. 27.4\u2009Kg\/m2).<\/jats:p><jats:p>\nNFPA was more frequent in older rather than younger patients. Males were older, had more HH and surgery. There was no significant improvement of pituitary function with surgery (17%) and 13% became iatrogenic HH. TRT had a low efficacy to improve ED in these patients.<\/jats:p>","DOI":"10.1055\/s-0042-124355","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T19:18:11Z","timestamp":1487186291000},"page":"368-376","source":"Crossref","is-referenced-by-count":9,"title":["Hypogonadotropic Hypogonadism in Non-Functioning Pituitary Adenomas: Impact of Intervention"],"prefix":"10.1055","volume":"125","author":[{"given":"Diana","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Gynaecology and Obstetrics Department, Unidade Local de Sa\u00fade de Matosinhos, Portugal; Faculty of Medicine University of Porto"}]},{"given":"Paula","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Centro Hospitalar S. Jo\u00e3o, Faculty of Medicine \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade University of Porto,Portugal"}]},{"given":"Romana","family":"Vieira","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Centro Hospitalar de S\u00e3o Jo\u00e3o, Porto, Portugal"}]},{"given":"Davide","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism Centro Hospitalar S. Jo\u00e3o, Faculty of Medicine \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade University of Porto,Portugal"}]}],"member":"194","published-online":{"date-parts":[[2017,2,15]]},"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0042-124355.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T02:19:51Z","timestamp":1513649991000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0042-124355"}},"subtitle":[""],"short-title":[],"issued":{"date-parts":[[2017,2,15]]},"references-count":0,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2017,6,20]]},"published-print":{"date-parts":[[2017,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0042-124355","relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,15]]}}}