{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:39:06Z","timestamp":1773887946394,"version":"3.50.1"},"reference-count":50,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"12","license":[{"start":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T00:00:00Z","timestamp":1703289600000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cervical cancer (CC) is caused by persistent infection of human papillomavirus of high oncogenic risk (hr-HPV); however, several cofactors are important in its carcinogenesis, such as smoking, multiparity, and prolonged use of oral hormonal contraceptives (COCs). Worldwide, 16% of women use COCs, whereas in Brazil this rate is of \u223c 30%. The safety and adverse effects of COCs are widely discussed in the literature, including the increase in carcinogenic risk. Due to the existence of several drugs, combinations, and dosages of COCs, it is hard to have uniform information in epidemiological studies. Our objective was to perform a narrative review on the role of COCs use in the carcinogenesis of cervical cancer. Several populational studies have suggested an increase in the incidence of cervical cancer for those who have used COCs for\u2009&gt;\u20095 years, but other available studies reach controversial and contradictory results regarding the action of COCs in the development of CC.<\/jats:p>","DOI":"10.1055\/s-0043-1776403","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T23:30:32Z","timestamp":1703374232000},"page":"e818-e824","source":"Crossref","is-referenced-by-count":15,"title":["Combined Oral Contraceptive Use and the Risk of Cervical Cancer: Literature Review"],"prefix":"10.61622","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9402-2571","authenticated-orcid":false,"given":"Adriane Cristina","family":"Bovo","sequence":"additional","affiliation":[{"name":"Hospital do C\u00e2ncer de Barretos, Barretos, S\u00e3o Paulo, Brazil."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0245-1089","authenticated-orcid":false,"given":"Priscila Grecca","family":"Pedr\u00e3o","sequence":"additional","affiliation":[{"name":"Hospital do C\u00e2ncer de Barretos, Barretos, S\u00e3o Paulo, Brazil."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8994-4195","authenticated-orcid":false,"given":"Yasmin Medeiros","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Hospital do C\u00e2ncer de Barretos, Barretos, S\u00e3o Paulo, Brazil."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1559-293X","authenticated-orcid":false,"given":"Luani Rezende","family":"Godoy","sequence":"additional","affiliation":[{"name":"Hospital do C\u00e2ncer de Barretos, Barretos, S\u00e3o Paulo, Brazil."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7869-3885","authenticated-orcid":false,"given":"J\u00falio C\u00e9sar Possati","family":"Resende","sequence":"additional","affiliation":[{"name":"Hospital do C\u00e2ncer de Barretos, Barretos, S\u00e3o Paulo, Brazil."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-9752","authenticated-orcid":false,"given":"Adhemar","family":"Longatto-Filho","sequence":"additional","affiliation":[{"name":"Hospital do C\u00e2ncer de Barretos, Barretos, S\u00e3o Paulo, Brazil."},{"name":"Faculdade de Medicia, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil."},{"name":"Life and Health Sciences Research Institute, Faculdade de Medicina, Universidade do Minho, Braga, Portugal."},{"name":"Government Associate Laboratory, Braga, Portugal."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8271-3690","authenticated-orcid":false,"given":"Ricardo dos","family":"Reis","sequence":"additional","affiliation":[{"name":"Hospital do C\u00e2ncer de Barretos, Barretos, S\u00e3o Paulo, Brazil."}]}],"member":"47794","published-online":{"date-parts":[[2023,12,23]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023","volume":"73","author":"R L Siegel","year":"2023","journal-title":"CA Cancer J Clin"},{"key":"ref2","first-page":"160","volume-title":"Estimativa 2023 : incid\u00eancia de c\u00e2ncer no Brasil. 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