{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:39:31Z","timestamp":1792172371901,"version":"4.4.0"},"reference-count":27,"publisher":"Massachusetts Medical Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NEJM Evidence"],"published-print":{"date-parts":[[2022,1,9]]},"DOI":"10.1056\/evidoa2100006","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T21:41:50Z","timestamp":1640209310000},"source":"Crossref","is-referenced-by-count":37,"title":["Acetazolamide to Prevent Adverse Altitude Effects in COPD and Healthy Adults"],"prefix":"10.1056","volume":"1","author":[{"given":"Michael","family":"Furian","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland"},{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maamed","family":"Mademilov","sequence":"additional","affiliation":[{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"},{"name":"Department of Respiratory Medicine, National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Buergin","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland"},{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp M.","family":"Scheiwiller","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland"},{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland"},{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland"},{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berik","family":"Emilov","sequence":"additional","affiliation":[{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"},{"name":"Department of Respiratory Medicine, National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Lichtblau","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland"},{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Bitos","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland"},{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Muralt","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland"},{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Groth","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland"},{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelia E.","family":"Reiser","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland"},{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Sevik","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland"},{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulan","family":"Sheraliev","sequence":"additional","affiliation":[{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"},{"name":"Department of Respiratory Medicine, National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuriddin H.","family":"Marazhapov","sequence":"additional","affiliation":[{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"},{"name":"Department of Respiratory Medicine, National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoira","family":"Aydaralieva","sequence":"additional","affiliation":[{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"},{"name":"Department of Respiratory Medicine, National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aybermet","family":"Muratbekova","sequence":"additional","affiliation":[{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"},{"name":"Department of Respiratory Medicine, National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aizhamal","family":"Tabyshova","sequence":"additional","affiliation":[{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"},{"name":"Department of Respiratory Medicine, National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ainura","family":"Abdraeva","sequence":"additional","affiliation":[{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"},{"name":"Department of Respiratory Medicine, National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Buenzli","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland"},{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talant M.","family":"Sooronbaev","sequence":"additional","affiliation":[{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"},{"name":"Department of Respiratory Medicine, National Center for Cardiology and Internal Medicine, Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland"},{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad E.","family":"Bloch","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, University Hospital of Zurich, Zurich, Switzerland"},{"name":"Swiss-Kyrgyz High-Altitude Medicine and Research Initiative, Zurich, Switzerland, and Bishkek, Kyrgyz Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.18111\/9789284420261"},{"key":"e_1_3_5_3_2","unstructured":"GOLD Science Committee. Global strategy for the diagnosis management and prevention of chronic obstructive pulmonary disease \u2014 2020 report. Global Initiative for Chronic Obstructive Lung Disease. 2020 (https:\/\/goldcopd.org\/wp-content\/uploads\/2019\/12\/GOLD-2020-FINAL-ver1.2-03Dec19_WMV.pdf)."},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy203"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000486450"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.7940"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.06.006"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.16192"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1214870"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.wem.2019.04.006"},{"key":"e_1_3_5_11_2","first-page":"CD009761","article-title":"Interventions for preventing high altitude illness: Part 1. Commonly-used classes of drugs","volume":"6","year":"2017","unstructured":"Nieto Estrada VH, Molano Franco D, Medina RD, Gonzalez Garay AG, Mart\u00ed-Carvajal AJ, Arevalo-Rodriguez I. Interventions for preventing high altitude illness: Part 1. Commonly-used classes of drugs. Cochrane Database Syst Rev 2017;6:CD009761.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.5.1450"},{"key":"e_1_3_5_13_2","first-page":"1086","article-title":"Acetazolamide use in severe chronic obstructive pulmonary disease. Pros and cons","volume":"14","year":"2017","unstructured":"Adamson R, Swenson ER. Acetazolamide use in severe chronic obstructive pulmonary disease. Pros and cons. Ann Am Thorac Soc 2017;14:1086-1093.","journal-title":"Ann Am Thorac Soc"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-7359-2_18"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00113102"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0375"},{"key":"e_1_3_5_17_2","first-page":"272","volume-title":"Hypoxia and molecular medicine: proceedings of the 8th International Hypoxia Symposium","unstructured":"Roach RC, Bartsch P, Hackett PH, Oelz O; Lake Louise Acute Mountain Sickness Scoring System Committee. The Lake Louise Acute Mountain Sickness Scoring System. In: Sutton JR, Coates G, Huston CS, editors. Hypoxia and molecular medicine: proceedings of the 8th International Hypoxia Symposium. Burlington, VT: Queen City Printers; 1993:272-274."},{"key":"e_1_3_5_18_2","first-page":"1063","article-title":"Procedures for the measurement of acute mountain sickness","volume":"54","year":"1983","unstructured":"Sampson JB, Cymerman A, Burse RL, Maher JT, Rock PB. Procedures for the measurement of acute mountain sickness. Aviat Space Environ Med 1983;54:1063-1073.","journal-title":"Aviat Space Environ Med"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/ham.2017.0164"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.94847"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.0067"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1590ST"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.12.052"},{"key":"e_1_3_5_25_2","first-page":"CD009567","article-title":"Interventions for treating acute high altitude illness","volume":"6","year":"2018","unstructured":"Simancas-Racines D, Arevalo-Rodriguez I, Osorio D, Franco JV, Xu Y, Hidalgo R. Interventions for treating acute high altitude illness. Cochrane Database Syst Rev 2018;6:CD009567.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4169"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201802-0382CI"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201406-234PS"}],"container-title":["NEJM Evidence"],"original-title":[],"language":"en","deposited":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T18:12:00Z","timestamp":1651169520000},"score":1,"resource":{"primary":{"URL":"https:\/\/evidence.nejm.org\/doi\/10.1056\/EVIDoa2100006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,9]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1,9]]}},"alternative-id":["10.1056\/EVIDoa2100006"],"URL":"https:\/\/doi.org\/10.1056\/evidoa2100006","relation":{},"ISSN":["2766-5526"],"issn-type":[{"value":"2766-5526","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1,9]]}}}