{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:56:37Z","timestamp":1772841397141,"version":"3.50.1"},"reference-count":31,"publisher":"Massachusetts Medical Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NEJM Evidence"],"published-print":{"date-parts":[[2026,2,24]]},"DOI":"10.1056\/evidoa2500038","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T14:30:34Z","timestamp":1771943434000},"source":"Crossref","is-referenced-by-count":1,"title":["Feasibility Trial of Prolonged versus Single-Dose Challenge in Penicillin Allergy"],"prefix":"10.1056","volume":"5","author":[{"given":"Morgan","family":"Rose","sequence":"first","affiliation":[{"name":"Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia"},{"name":"The Peter Doherty Institute for Infection and Immunity, Department of Infectious Diseases, University of Melbourne, Melbourne, VIC, Australia"},{"name":"Department of Infectious Diseases, Peter MacCallum Cancer Centre, National Centre for Infections in Cancer, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Vogrin","sequence":"additional","affiliation":[{"name":"Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia"},{"name":"The Peter Doherty Institute for Infection and Immunity, Department of Infectious Diseases, University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise A.","family":"Mitri","sequence":"additional","affiliation":[{"name":"Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia"},{"name":"The Peter Doherty Institute for Infection and Immunity, Department of Infectious Diseases, University of Melbourne, Melbourne, VIC, Australia"},{"name":"National Allergy Centre of Excellence, Parkville, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"De Luca","sequence":"additional","affiliation":[{"name":"Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia"},{"name":"The Peter Doherty Institute for Infection and Immunity, Department of Infectious Diseases, University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Lapirow","sequence":"additional","affiliation":[{"name":"Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma K.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia"},{"name":"Department of Infectious Diseases, Peter MacCallum Cancer Centre, National Centre for Infections in Cancer, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Hall","sequence":"additional","affiliation":[{"name":"Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia"},{"name":"The Peter Doherty Institute for Infection and Immunity, Department of Infectious Diseases, University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerryn","family":"McInnes","sequence":"additional","affiliation":[{"name":"Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia"},{"name":"The Peter Doherty Institute for Infection and Immunity, Department of Infectious Diseases, University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona","family":"James","sequence":"additional","affiliation":[{"name":"Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia"},{"name":"The Peter Doherty Institute for Infection and Immunity, Department of Infectious Diseases, University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irvin","family":"Ng","sequence":"additional","affiliation":[{"name":"Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia"},{"name":"The Peter Doherty Institute for Infection and Immunity, Department of Infectious Diseases, University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, St George Hospital, School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales, Kogarah, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lane","sequence":"additional","affiliation":[{"name":"Royal Brisbane and Women\u2019s Hospital, Herston, QLD, Australia"},{"name":"Centre for Clinical Research, University of Queensland, Herston, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Legg","sequence":"additional","affiliation":[{"name":"Royal Brisbane and Women\u2019s Hospital, Herston, QLD, Australia"},{"name":"Centre for Clinical Research, University of Queensland, Herston, QLD, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Copaescu","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology, McGill University Hospital, McGill University, Montr\u00e9al, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle S.","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Austin Health, Heidelberg, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyra Y. L.","family":"Chua","sequence":"additional","affiliation":[{"name":"Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia"},{"name":"The Peter Doherty Institute for Infection and Immunity, Department of Infectious Diseases, University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha E.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia"},{"name":"The Peter Doherty Institute for Infection and Immunity, Department of Infectious Diseases, University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A.","family":"Trubiano","sequence":"additional","affiliation":[{"name":"Centre for Antibiotic Allergy and Research, Department of Infectious Diseases and Immunology, Austin Health, Heidelberg, VIC, Australia"},{"name":"The Peter Doherty Institute for Infection and Immunity, Department of Infectious Diseases, University of Melbourne, Melbourne, VIC, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"150","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw008"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw462"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.5694\/mja15.01329"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k2400"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13830"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32218-9"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy306"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/clt2.12008"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2024.4606"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.08.028"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1254"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.12195"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2014.11.001"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.01.018"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.02.024"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12826"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000320384"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(84)90487-1"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70499-8"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.7.822"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.06.014"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-094712"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2018.07.048"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2020.0403"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12501"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2019.50"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03250-0"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40521-019-00229-8"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa653"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2023.2986"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-024-07448-x"}],"container-title":["NEJM Evidence"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:30:59Z","timestamp":1772807459000},"score":1,"resource":{"primary":{"URL":"https:\/\/evidence.nejm.org\/doi\/10.1056\/EVIDoa2500038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,24]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2,24]]}},"alternative-id":["10.1056\/EVIDoa2500038"],"URL":"https:\/\/doi.org\/10.1056\/evidoa2500038","relation":{},"ISSN":["2766-5526"],"issn-type":[{"value":"2766-5526","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2,24]]}}}