{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:58:49Z","timestamp":1785340729892,"version":"3.55.0"},"reference-count":32,"publisher":"Massachusetts Medical Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NEJM Evidence"],"published-print":{"date-parts":[[2026,7,28]]},"DOI":"10.1056\/evidoa2500271","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:31:02Z","timestamp":1785245462000},"source":"Crossref","is-referenced-by-count":1,"title":["Gram-Positive Bacteria and the Inverse Association between Farm Exposure and Childhood Asthma"],"prefix":"10.1056","volume":"5","author":[{"given":"Giulia","family":"Pagani","sequence":"first","affiliation":[{"name":"Institute of Asthma and Allergy Prevention, Helmholtz Munich, Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Loss","sequence":"additional","affiliation":[{"name":"Dr von Hauner Children\u2019s Hospital, LMU Munich, Munich, Germany"},{"name":"Department of Pediatrics, University of California at San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali","family":"Pechlivanis","sequence":"additional","affiliation":[{"name":"Institute of Asthma and Allergy Prevention, Helmholtz Munich, Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Depner","sequence":"additional","affiliation":[{"name":"Institute of Asthma and Allergy Prevention, Helmholtz Munich, Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanze","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Research Unit Analytical Biogeochemistry, Helmholtz Munich, Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Ru","sequence":"additional","affiliation":[{"name":"Institute for Disease Prevention, Technical University of Munich, Freising, Germany"},{"name":"Institute of Virology, Helmholtz Munich, Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Strunz-Lehner","sequence":"additional","affiliation":[{"name":"Dr von Hauner Children\u2019s Hospital, LMU Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Humphrey","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California at San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Ackermann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California at San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amnon","family":"Amir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California at San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Melnik","sequence":"additional","affiliation":[{"name":"Arome Science and BileOmix, Farmington, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Garg","sequence":"additional","affiliation":[{"name":"Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Knight","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California at San Diego, La Jolla, CA, USA"},{"name":"Department of Computer Science & Engineering, University of California at San Diego, La Jolla, CA, USA"},{"name":"Hal\u0131c\u0131o\u011flu Data Science Institute, University of California at San Diego, La Jolla, CA, USA"},{"name":"Shu Chien-Gene Lay Department of Bioengineering, University of California at San Diego, La Jolla, CA, USA"},{"name":"Center for Microbiome Innovation, University of California at San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter C.","family":"Dorrestein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California at San Diego, La Jolla, CA, USA"},{"name":"Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA, USA"},{"name":"Center for Microbiome Innovation, University of California at San Diego, La Jolla, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Schmitt-Kopplin","sequence":"additional","affiliation":[{"name":"Research Unit Analytical Biogeochemistry, Helmholtz Munich, Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Deng","sequence":"additional","affiliation":[{"name":"Institute for Disease Prevention, Technical University of Munich, Freising, Germany"},{"name":"Institute of Virology, Helmholtz Munich, Neuherberg, Germany"},{"name":"Member of the German Center for Lung Research (DZL), Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schloter","sequence":"additional","affiliation":[{"name":"Member of the German Center for Lung Research (DZL), Munich, Germany"},{"name":"Research Unit for Comparative Microbiome Analysis, Helmholtz Munich, Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Divaret-Chauveau","sequence":"additional","affiliation":[{"name":"Pediatric Allergy Department, Children\u2019s Hospital, University Hospital of Nancy, Vandoeuvre les Nancy, France"},{"name":"EA 3450 DevAH, Faculty of Medicine, University of Lorraine, Vandoeuvre les Nancy, France"},{"name":"UMR\/CNRS 6249 Chrono-environnement, University of Bourgogne Franche-Comt\u00e9, Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Roduit","sequence":"additional","affiliation":[{"name":"Christine K\u00fchne Center for Allergy Research and Education (CK-CARE), Davos, Switzerland"},{"name":"Division of Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Karvonen","sequence":"additional","affiliation":[{"name":"Department of Public Health, Finnish Institute for Health and Welfare, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Genuneit","sequence":"additional","affiliation":[{"name":"Institute for Public Health, Medical Faculty, Goethe-University Frankfurt, Frankfurt\/Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"von Mutius","sequence":"additional","affiliation":[{"name":"Institute of Asthma and Allergy Prevention, Helmholtz Munich, Neuherberg, Germany"},{"name":"Dr von Hauner Children\u2019s Hospital, LMU Munich, Munich, Germany"},{"name":"Member of the German Center for Lung Research (DZL), Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus J.","family":"Ege","sequence":"additional","affiliation":[{"name":"Institute of Asthma and Allergy Prevention, Helmholtz Munich, Neuherberg, Germany"},{"name":"Dr von Hauner Children\u2019s Hospital, LMU Munich, Munich, Germany"},{"name":"Member of the German Center for Lung Research (DZL), Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra054308"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201702-139AW"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007302"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1508749"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1095-x"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201503-133AW"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.13002"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2011.01223.x"},{"key":"e_1_3_5_10_2","unstructured":"Earth Microbiome Project. Protocols and standards. 2026 (https:\/\/earthmicrobiome.ucsd.edu\/protocols-and-standards\/dna-extraction-protocol\/)."},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13361-015-1101-6"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa290"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.1029"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01688-w"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-020-0548-6"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.65088"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-022-00738-y"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv402"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.11.017"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020057"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac6623"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903670"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228797"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.110797"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252313072"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.9.4318"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-017-0574-7"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.05.013"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.05.050"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052632"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo10030097"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-021-01022-x"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-013-9837-4"}],"container-title":["NEJM Evidence"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:07:43Z","timestamp":1785337663000},"score":1,"resource":{"primary":{"URL":"https:\/\/evidence.nejm.org\/doi\/10.1056\/EVIDoa2500271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,7,28]]}},"alternative-id":["10.1056\/EVIDoa2500271"],"URL":"https:\/\/doi.org\/10.1056\/evidoa2500271","relation":{},"ISSN":["2766-5526"],"issn-type":[{"value":"2766-5526","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,28]]}}}