{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:12:40Z","timestamp":1768273960781,"version":"3.49.0"},"reference-count":5,"publisher":"Massachusetts Medical Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[1970,7,2]]},"DOI":"10.1056\/nejm197007022830104","type":"journal-article","created":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T20:11:40Z","timestamp":1280347900000},"page":"15-20","source":"Crossref","is-referenced-by-count":302,"title":["Tay-Sachs Disease"],"prefix":"10.1056","volume":"283","author":[{"given":"John S.","family":"O'Brien","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy L.","family":"Fillerup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.1126\/science.165.3894.698"},{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(69)90947-4"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(69)90311-8"},{"key":"r004","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1042\/bj1070321","volume":"107","author":"Robinson","year":"1968","journal-title":"Biochem J"},{"key":"r005","unstructured":"Aronson SM: Epidemiology, Tay\u2013Sachs Disease. Edited by BW Volk. New York, Grune and Stratton, 1964, pp 118\u2013153"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJM197007022830104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T21:26:03Z","timestamp":1559337963000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJM197007022830104"}},"subtitle":["Detection of Heterozygotes and Homozygotes by Serum Hexosaminidase Assay"],"short-title":[],"issued":{"date-parts":[[1970,7,2]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1970,7,2]]}},"alternative-id":["10.1056\/NEJM197007022830104"],"URL":"https:\/\/doi.org\/10.1056\/nejm197007022830104","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,7,2]]}}}