{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T19:58:42Z","timestamp":1781121522756,"version":"3.54.1"},"reference-count":27,"publisher":"Massachusetts Medical Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[1976,7,15]]},"DOI":"10.1056\/nejm197607152950302","type":"journal-article","created":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T20:47:10Z","timestamp":1280350030000},"page":"125-130","source":"Crossref","is-referenced-by-count":56,"title":["Hemoglobin Beth Israel"],"prefix":"10.1056","volume":"295","author":[{"given":"Ronald L.","family":"Nagel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Lynfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Landau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Bookchin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","first-page":"385","volume":"11","author":"Nagel","year":"1974","journal-title":"Semin Hematol"},{"key":"r002","first-page":"423","volume":"11","author":"Rieder","year":"1974","journal-title":"Semin Hematol"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104406"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106200"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(70)90164-9"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2795(75)90192-0"},{"key":"r007","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0021-9258(17)41272-5","volume":"164","author":"Drabkin","year":"1946","journal-title":"J Biol Chem"},{"key":"r008","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1042\/bj0710585","volume":"71","author":"Smithies","year":"1959","journal-title":"Biochem J"},{"key":"r009","unstructured":"Dacie JV, Lewis SM: Practical Haematology. Third edition. New York, Grune and Stratton, Incorporated, 1963"},{"key":"r010","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1182\/blood.V34.2.157.157","volume":"34","author":"Nagel","year":"1969","journal-title":"Blood"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103561"},{"key":"r012","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0021-9258(18)97685-4","volume":"240","author":"Bucci","year":"1965","journal-title":"J Biol Chem"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.13.4.469"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(66)80052-9"},{"key":"r015","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1042\/bj0490463","volume":"49","author":"Sanger","year":"1951","journal-title":"Biochem J"},{"key":"r016","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0021-9258(19)81457-6","volume":"242","author":"Bookchin","year":"1967","journal-title":"J Biol Chem"},{"key":"r017","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0021-9258(19)50965-6","volume":"187","author":"Allen","year":"1950","journal-title":"J Biol Chem"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(70)90023-0"},{"key":"r020","unstructured":"Antonini E, Brunori M: Hemoglobin and myoglobin in their reactions with ligands. Vol 21. New York, American Elsevier Publishing Company, 1971"},{"key":"r021","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S0021-9258(18)93612-4","volume":"243","author":"Bonaventura","year":"1968","journal-title":"J Biol Chem"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1972.036.01.040"},{"key":"r023","doi-asserted-by":"crossref","first-page":"6105","DOI":"10.1016\/S0021-9258(18)63512-4","volume":"244","author":"Efremov","year":"1969","journal-title":"J Biol Chem"},{"key":"r024","doi-asserted-by":"crossref","first-page":"5976","DOI":"10.1016\/S0021-9258(19)43496-0","volume":"248","author":"Gibson","year":"1973","journal-title":"J Biol Chem"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.6.1718"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(75)90403-9"},{"key":"r027","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106103"},{"key":"r028","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196910232811701"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJM197607152950302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T01:42:28Z","timestamp":1635817348000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJM197607152950302"}},"subtitle":["A Mutant Causing Clinically Apparent Cyanosis"],"short-title":[],"issued":{"date-parts":[[1976,7,15]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1976,7,15]]}},"alternative-id":["10.1056\/NEJM197607152950302"],"URL":"https:\/\/doi.org\/10.1056\/nejm197607152950302","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[1976,7,15]]}}}