{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T06:27:28Z","timestamp":1794292048283,"version":"4.9.0"},"reference-count":33,"publisher":"Massachusetts Medical Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[1979,3,8]]},"DOI":"10.1056\/nejm197903083001001","type":"journal-article","created":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T17:01:38Z","timestamp":1280336498000},"page":"513-517","source":"Crossref","is-referenced-by-count":476,"title":["Sleep Apnea, Hypopnea and Oxygen Desaturation in Normal Subjects"],"prefix":"10.1056","volume":"300","author":[{"given":"A. Jay","family":"Block","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip G.","family":"Boysen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Wynne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn A.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-76-2-185"},{"key":"r002","first-page":"1087","volume":"8","author":"Tassinari","year":"1972","journal-title":"Bull Physiopathol Respir (Nancy)"},{"key":"r003","first-page":"1103","volume":"8","author":"Lugaresi","year":"1972","journal-title":"Bull Physiopathol Respir (Nancy)"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.27.020176.002341"},{"key":"r005","unstructured":"Guilleminault C, van den Hoed J, Mitler MM: Clinical overview of the sleep apnea syndromes, Sleep Apnea Syndromes. Edited by C Guilleminault, WC Dement. New York, Alan R Liss, 1978, pp 1\u201312"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1136\/thx.31.6.730"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-6-725"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1378\/chest.73.2_Supplement.301-a"},{"key":"r009","first-page":"3","volume":"143","author":"Wynne","year":"1978","journal-title":"Johns Hopkins Med J"},{"key":"r010","first-page":"457","volume":"79","author":"Goldman","year":"1959","journal-title":"Am Rev Respir Dis"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(66)90008-8"},{"key":"r012","first-page":"990","volume":"6","author":"Flick","year":"1977","journal-title":"Heart Lung"},{"key":"r013","unstructured":"Agnew HW Jr, Webb WB: Sleep stage scoring (American Psychological Association Abstract Series, Manuscript No. 293). Washington, DC, American Psychological Association, 1972"},{"key":"r014","unstructured":"Williams RL, Karacan I, Hursch CJ: Electroencephalography (EEG) of Human Sleep: Clinical applications. New York, Wiley, 1974"},{"key":"r015","first-page":"719","volume":"22","author":"Mantel","year":"1959","journal-title":"J Natl Cancer Inst"},{"key":"r016","first-page":"95","volume":"117","author":"Block","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1966.tb02650.x"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103694"},{"key":"r019","first-page":"216","volume":"54","author":"Birchfield","year":"1959","journal-title":"J Lab Clin Med"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-52-3-500"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1126\/science.150.3697.763-a"},{"issue":"209","key":"r022","first-page":"1","volume":"59","author":"B\u00fclow","year":"1963","journal-title":"Acta Physiol Scand"},{"key":"r023","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1152\/jappl.1974.37.6.899","volume":"37","author":"Webb","year":"1974","journal-title":"J Appl Physiol"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(75)90127-3"},{"key":"r025","first-page":"293","volume":"73","author":"Guilleminault","year":"1978","journal-title":"Chest"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(78)90204-3"},{"key":"r027","first-page":"38A","volume":"26","author":"Orr","year":"1978","journal-title":"Clin Res"},{"key":"r028","doi-asserted-by":"crossref","unstructured":"Lugaresi E, Coccagna G, Cirignotta F, et al: Breathing during sleep in man in normal and pathologic conditions, The Regulation of Respiration during Sleep and Anesthesia. Edited by RS Fitzgerald, H Gautier, S Lahiri. New York, Plenum Press, 1978, pp 35\u201345","DOI":"10.1007\/978-1-4613-4009-6_5"},{"key":"r029","unstructured":"Lugaresi E, Coccagna G, Cirignotta F: Snoring and its clinical implications, Sleep Apnea Syndromes. Edited by C Guilleminault, WC Dement. New York, Alan R Liss, 1978, pp 13\u201321"},{"key":"r030","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1378\/chest.73.2_Supplement.303","volume":"73","author":"Kryger","year":"1978","journal-title":"Chest"},{"key":"r031","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(68)90088-0"},{"key":"r032","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-83-4-476"},{"key":"r033","first-page":"455","volume":"117","author":"Kryger","year":"1978","journal-title":"Am Rev Respir Dis"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJM197903083001001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T18:08:44Z","timestamp":1559326124000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJM197903083001001"}},"subtitle":["A Strong Male Predominance"],"short-title":[],"issued":{"date-parts":[[1979,3,8]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1979,3,8]]}},"alternative-id":["10.1056\/NEJM197903083001001"],"URL":"https:\/\/doi.org\/10.1056\/nejm197903083001001","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,3,8]]}}}