{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T13:47:58Z","timestamp":1793972878458,"version":"4.8.0"},"reference-count":12,"publisher":"Massachusetts Medical Society","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[1985,4,18]]},"DOI":"10.1056\/nejm198504183121602","type":"journal-article","created":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T21:30:55Z","timestamp":1280352655000},"page":"1011-1015","source":"Crossref","is-referenced-by-count":136,"title":["Trial of Penicillamine in Advanced Primary Biliary Cirrhosis"],"prefix":"10.1056","volume":"312","author":[{"given":"E. Rolland","family":"Dickson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell H.","family":"Wiesner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P.","family":"Baldus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Richard","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T.","family":"McCall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","first-page":"487","volume":"6","author":"Dickson","year":"1979","journal-title":"Prog Liver Dis"},{"key":"r002","unstructured":"Dickson ER, Fleming CR, Baldus WP. Primary biliary cirrhosis: past, present, and speculations on the future. In: Berk PD, Chalmers TC, eds. Frontiers in liver disease. New York: Thieme-Stratton, 1981:242\u201354."},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1038\/newbio240220a0"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109759"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb36059.x"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.2307\/2281868"},{"key":"r007","first-page":"163","volume":"50","author":"Mantel","year":"1966","journal-title":"Cancer Chemother Rep"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.2307\/2556114"},{"key":"r009","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","volume":"34","author":"Cox","year":"1972","journal-title":"J R Stat Soc (B)"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(83)70166-0"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92456-9"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198202113060602"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJM198504183121602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T14:40:30Z","timestamp":1740321630000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJM198504183121602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,4,18]]},"references-count":12,"journal-issue":{"issue":"16","published-print":{"date-parts":[[1985,4,18]]}},"alternative-id":["10.1056\/NEJM198504183121602"],"URL":"https:\/\/doi.org\/10.1056\/nejm198504183121602","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,4,18]]}}}