{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:41:21Z","timestamp":1783633281705,"version":"3.55.0"},"reference-count":40,"publisher":"Massachusetts Medical Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[1988,2,25]]},"DOI":"10.1056\/nejm198802253180804","type":"journal-article","created":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T21:46:20Z","timestamp":1280353580000},"page":"478-484","source":"Crossref","is-referenced-by-count":252,"title":["The Clinical Outcome of Prospective Screening for Multiple Endocrine Neoplasia Type 2A"],"prefix":"10.1056","volume":"318","author":[{"given":"Robert F.","family":"Gagel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Armen H.","family":"Tashjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Papathanasopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael M.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald A.","family":"DeLellis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert J.","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seymour","family":"Reichlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1056\/NEJM197111112852004","volume":"285","author":"Melvin","year":"1971","journal-title":"N Engl J Med"},{"key":"r002","first-page":"225","volume":"32","author":"Telenius-Berg","year":"1984","journal-title":"Henry Ford Hosp Med J"},{"key":"r003","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0002-9343(61)90234-0","volume":"31","author":"Sipple","year":"1961","journal-title":"Am J Med"},{"key":"r004","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/00005792-196809000-00001","volume":"47","author":"Steiner","year":"1968","journal-title":"Medicine"},{"key":"r005","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1073\/pnas.60.1.293","volume":"60","author":"Deftos","year":"1968","journal-title":"Proc Natl Acad Sci USA"},{"key":"r006","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0140-6736(69)92389-7","volume":"2","author":"Clark","year":"1969","journal-title":"Lancet"},{"key":"r007","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1056\/NEJM197010222831702","volume":"283","author":"Tashjian","year":"1970","journal-title":"N Engl J Med"},{"key":"r008","first-page":"399","volume":"28","author":"Melvin","year":"1972","journal-title":"Recent Prog Horm Res"},{"key":"r009","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1056\/NEJM197811022991804","volume":"299","author":"Graze","year":"1978","journal-title":"N Engl J Med"},{"key":"r010","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/00000478-198107000-00005","volume":"5","author":"Bigner","year":"1981","journal-title":"Am J Surg Pathol"},{"key":"r011","first-page":"995","volume":"94","author":"Jackson","year":"1983","journal-title":"Surgery"},{"key":"r012","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0039-6109(16)41279-X","volume":"57","author":"Sizemore","year":"1977","journal-title":"Surg Clin North Am"},{"key":"r013","doi-asserted-by":"crossref","first-page":"561","DOI":"10.7326\/0003-4819-78-4-561","volume":"78","author":"Keiser","year":"1973","journal-title":"Ann Intern Med"},{"key":"r014","first-page":"254","volume":"32","author":"Sisson","year":"1984","journal-title":"Henry Ford Hosp Med J"},{"key":"r015","first-page":"177","volume":"88","author":"Gagel","year":"1975","journal-title":"Trans Assoc Am Physicians"},{"key":"r016","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/0002-9343(78)90757-X","volume":"65","author":"Hamilton","year":"1978","journal-title":"Am J Med"},{"key":"r017","first-page":"246","volume":"32","author":"Takai","year":"1984","journal-title":"Henry Ford Hosp Med J"},{"key":"r018","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/00000658-195703000-00004","volume":"145","author":"Crile","year":"1957","journal-title":"Ann Surg"},{"key":"r019","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0022-3468(76)90111-1","volume":"11","author":"Leape","year":"1976","journal-title":"J Pediatr Surg"},{"key":"r020","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/0002-9610(72)90197-3","volume":"123","author":"Miller","year":"1972","journal-title":"Am J Surg"},{"key":"r021","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1056\/NEJM197308302890901","volume":"289","author":"Wolfe","year":"1973","journal-title":"N Engl J Med"},{"key":"r022","first-page":"237","volume":"36","author":"DeLellis","year":"1977","journal-title":"Lab Invest"},{"key":"r023","unstructured":"Sandhu RS, Freed RM. Catecholamines and associated metabolites in human urine. In: Cooper GR, ed. Standard methods of clinical chemistry. Vol. 7. New York: Academic Press, 1972:231\u201346."},{"key":"r024","unstructured":"Nichols Institute. Radioimmunoassay manual. San Juan Capistrano, Calif.: Nichols Institute, 1974:171\u201381."},{"key":"r025","first-page":"94","volume":"35","author":"Gagel","year":"1987","journal-title":"Henry Ford Hosp Med J"},{"key":"r026","first-page":"177","volume":"83","author":"DeLellis","year":"1976","journal-title":"Am J Pathol"},{"key":"r027","first-page":"129","volume":"35","author":"Motte","year":"1987","journal-title":"Henry Ford Hosp Med"},{"key":"r028","unstructured":"Tashjian AH Jr, Voelkel EF. Radioimmunoassay of human calcitonin: application of affinity chromatography. In: Jaffe BM, Behrman H, eds. Methods of hormone radioimmunoassay. New York: Academic Press, 1974:199\u2013214."},{"key":"r029","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/0026-0495(71)90037-0","volume":"20","author":"Deftos","year":"1971","journal-title":"Metabolism"},{"key":"r030","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/clinchem\/30.4.511","volume":"30","author":"Body","year":"1984","journal-title":"Clin Chem"},{"key":"r031","first-page":"60","volume":"99","author":"Tisell","year":"1986","journal-title":"Surgery"},{"key":"r032","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1210\/jcem-43-2-428","volume":"43","author":"Heath","year":"1976","journal-title":"J Clin Endocrinol Metab"},{"key":"r033","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1056\/NEJM198605153142004","volume":"314","author":"Brandi","year":"1986","journal-title":"N Engl J Med"},{"key":"r034","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.3616618","volume":"237","author":"Suva","year":"1987","journal-title":"Science"},{"key":"r035","doi-asserted-by":"crossref","first-page":"776","DOI":"10.7326\/0003-4819-102-6-776","volume":"102","author":"Stewart","year":"1985","journal-title":"Ann Intern Med"},{"key":"r036","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.0954-6820.1987.tb10683.x","volume":"222","author":"Telenius-Berg","year":"1987","journal-title":"Acta Med Scand"},{"key":"r037","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1056\/NEJM198605013141803","volume":"314","author":"O'Connor","year":"1986","journal-title":"N Engl J Med"},{"key":"r038","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/328527a0","volume":"328","author":"Mathew","year":"1987","journal-title":"Nature"},{"key":"r039","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/328528a0","volume":"328","author":"Simpson","year":"1987","journal-title":"Nature"},{"key":"r040","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0022-3476(82)80014-0","volume":"101","author":"Gagel","year":"1982","journal-title":"J Pediatr"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJM198802253180804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T18:00:10Z","timestamp":1591725610000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJM198802253180804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,2,25]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1988,2,25]]}},"alternative-id":["10.1056\/NEJM198802253180804"],"URL":"https:\/\/doi.org\/10.1056\/nejm198802253180804","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,2,25]]}}}