{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:15:41Z","timestamp":1787004941445,"version":"build-2736575974"},"reference-count":31,"publisher":"Massachusetts Medical Society","issue":"26","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[1988,12,29]]},"DOI":"10.1056\/nejm198812293192602","type":"journal-article","created":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T17:47:51Z","timestamp":1280339271000},"page":"1692-1698","source":"Crossref","is-referenced-by-count":172,"title":["Acyclovir Treatment of the Chronic Fatigue Syndrome"],"prefix":"10.1056","volume":"319","author":[{"given":"Stephen E.","family":"Straus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet K.","family":"Dale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Tobi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Lawley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Preble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Michael","family":"Blaese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Hallahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Henle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/infdis\/157.3.405","volume":"157","author":"Straus","year":"1988","journal-title":"J Infect Dis"},{"key":"r002","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0140-6736(82)90210-0","volume":"1","author":"Tobi","year":"1982","journal-title":"Lancet"},{"key":"r003","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1097\/00007611-198411000-00007","volume":"77","author":"DuBois","year":"1984","journal-title":"South Med J"},{"key":"r004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-102-1-","volume":"102","author":"Jones","year":"1985","journal-title":"Ann Intern Med"},{"key":"r005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.7326\/0003-4819-102-1-7","volume":"102","author":"Straus","year":"1985","journal-title":"Ann Intern Med"},{"key":"r006","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1093\/infdis\/151.6.1150","volume":"151","author":"Horwitz","year":"1985","journal-title":"J Infect Dis"},{"key":"r007","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1001\/jama.1987.03390170053027","volume":"257","author":"Holmes","year":"1987","journal-title":"JAMA"},{"key":"r008","doi-asserted-by":"crossref","first-page":"387","DOI":"10.7326\/0003-4819-108-3-387","volume":"108","author":"Holmes","year":"1988","journal-title":"Ann Intern Med"},{"key":"r009","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/infdis\/153.2.283","volume":"153","author":"Andersson","year":"1986","journal-title":"J Infect Dis"},{"key":"r010","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1128\/JVI.34.2.560-568.1980","volume":"34","author":"Colby","year":"1980","journal-title":"J Virol"},{"key":"r011","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0091-6749(88)90933-5","volume":"81","author":"Straus","year":"1988","journal-title":"J Allergy Clin Immunol"},{"key":"r012","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0046-8177(74)80006-7","volume":"5","author":"Henle","year":"1974","journal-title":"Hum Pathol"},{"key":"r013","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/ijc.2910110302","volume":"11","author":"Reedman","year":"1973","journal-title":"Int J Cancer"},{"key":"r014","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.4049\/jimmunol.123.3.1382","volume":"123","author":"Lawley","year":"1979","journal-title":"J Immunol"},{"key":"r015","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1172\/JCI108257","volume":"57","author":"Theofilopoulos","year":"1976","journal-title":"J Clin Invest"},{"key":"r016","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1126\/science.6176024","volume":"216","author":"Preble","year":"1982","journal-title":"Science"},{"key":"r017","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1073\/pnas.80.16.4954","volume":"80","author":"Jacobsen","year":"1983","journal-title":"Proc Natl Acad Sci USA"},{"key":"r018","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/0002-9343(88)90313-0","volume":"84","author":"Sawyer","year":"1988","journal-title":"Am J Med"},{"key":"r019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijc.2910170102","volume":"17","author":"Henle","year":"1976","journal-title":"Int J Cancer"},{"key":"r020","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1136\/jcp.32.10.1036","volume":"32","author":"Edwards","year":"1979","journal-title":"J Clin Pathol"},{"key":"r021","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/infdis\/156.1.26","volume":"156","author":"Miller","year":"1987","journal-title":"J Infect Dis"},{"key":"r022","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1073\/pnas.84.2.570","volume":"84","author":"Henle","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"r023","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1136\/bmj.287.6385.85","volume":"287","author":"Hamblin","year":"1983","journal-title":"Br Med J"},{"key":"r024","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.4049\/jimmunol.134.5.3082","volume":"134","author":"Tosato","year":"1985","journal-title":"J Immunol"},{"key":"r025","first-page":"111","volume":"58","author":"Borysiewicz","year":"1986","journal-title":"Q J Med"},{"key":"r026","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/BF00915168","volume":"5","author":"Kibler","year":"1985","journal-title":"J Clin Immunol"},{"key":"r027","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.4049\/jimmunol.139.10.3306","volume":"139","author":"Caligiuri","year":"1987","journal-title":"J Immunol"},{"key":"r028","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1056\/NEJM198406143102401","volume":"310","author":"Straus","year":"1984","journal-title":"N Engl J Med"},{"key":"r029","first-page":"33","volume":"47","author":"Brigden","year":"1985","journal-title":"Scand J Infect Dis [Suppl]"},{"key":"r030","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1001\/archinte.1961.03620090065008","volume":"108","author":"Imboden","year":"1961","journal-title":"Arch Intern Med"},{"key":"r031","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2190\/8R67-N9ER-XR74-9RA7","volume":"17","author":"Taerk","year":"1987","journal-title":"Int J Psych Med"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJM198812293192602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T08:31:29Z","timestamp":1685694689000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJM198812293192602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,12,29]]},"references-count":31,"journal-issue":{"issue":"26","published-print":{"date-parts":[[1988,12,29]]}},"alternative-id":["10.1056\/NEJM198812293192602"],"URL":"https:\/\/doi.org\/10.1056\/nejm198812293192602","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,12,29]]}}}