{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:02:34Z","timestamp":1793138554449,"version":"4.5.0"},"reference-count":21,"publisher":"Massachusetts Medical Society","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[1989,5,18]]},"DOI":"10.1056\/nejm198905183202001","type":"journal-article","created":{"date-parts":[[2010,7,28]],"date-time":"2010-07-28T17:49:58Z","timestamp":1280339398000},"page":"1293-1299","source":"Crossref","is-referenced-by-count":821,"title":["Mitochondrial DNA Deletions in Progressive External Ophthalmoplegia and Kearns-Sayre Syndrome"],"prefix":"10.1056","volume":"320","author":[{"given":"Carlos T.","family":"Moraes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"DiMauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Zeviani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Lombes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Shanske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand F.","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Nakase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Bonilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lineu C.","family":"Werneck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serenella","family":"Servidei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuya","family":"Nonaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutoshi","family":"Koga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred J.","family":"Spiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Keith","family":"W. Brownell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beny","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald L.","family":"Schotland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Zupanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl C.","family":"DeVivo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A.","family":"Schon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis P.","family":"Rowland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","first-page":"137","volume":"23","author":"Wallace","year":"1987","journal-title":"Birth Defects"},{"key":"r002","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0733-8619(18)30832-6","volume":"7","author":"Zeviani","year":"1989","journal-title":"Neurol Clin"},{"key":"r003","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/331717a0","volume":"331","author":"Holt","year":"1988","journal-title":"Nature"},{"key":"r004","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1212\/WNL.38.9.1339","volume":"38","author":"Zeviani","year":"1988","journal-title":"Neurology"},{"key":"r005","unstructured":"Tome FMS, Fardeau M. Ocular myopathies. In: Engel AG, Banker BQ, eds. Myology: basic and clinical. Vol. 2. New York: McGraw-Hill, 1986: 1327\u201347."},{"key":"r006","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/ana.410240609","volume":"24","author":"Koga","year":"1988","journal-title":"Ann Neurol"},{"key":"r007","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0022-510X(76)90063-0","volume":"27","author":"DiMauro","year":"1976","journal-title":"J Neurol Sci"},{"key":"r008","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1001\/archneur.1976.00500070017003","volume":"33","author":"Schotland","year":"1976","journal-title":"Arch Neurol"},{"key":"r009","doi-asserted-by":"crossref","unstructured":"Davis LG, Dibner MD, Battey JF, eds. Basic methods in molecular biology. New York: Elsevier, 1986:47\u201350.","DOI":"10.1016\/B978-0-444-01082-7.50020-5"},{"key":"r010","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/ana.410220409","volume":"22","author":"DiMauro","year":"1987","journal-title":"Ann Neurol"},{"key":"r011","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/0006-2944(78)90037-6","volume":"19","author":"Bookelman","year":"1978","journal-title":"Biochem Med"},{"key":"r012","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0014-5793(85)80122-8","volume":"192","author":"Palva","year":"1985","journal-title":"FEBS Lett"},{"key":"r013","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/0003-2697(83)90418-9","volume":"132","author":"Feinberg","year":"1983","journal-title":"Anal Biochem"},{"key":"r014","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0378-1119(87)90281-2","volume":"55","author":"Zeviani","year":"1987","journal-title":"Gene"},{"key":"r015","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1093\/nar\/14.6.2597","volume":"14","author":"Kristensen","year":"1986","journal-title":"Nucleic Acids Res"},{"key":"r016","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/290457a0","volume":"290","author":"Anderson","year":"1981","journal-title":"Nature"},{"key":"r017","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/S0140-6736(88)92273-8","volume":"1","author":"Holt","year":"1988","journal-title":"Lancet"},{"key":"r018","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0140-6736(88)91632-7","volume":"1","author":"Lestienne","year":"1988","journal-title":"Lancet"},{"key":"r019","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ar.1092140103","volume":"214","author":"Carry","year":"1986","journal-title":"Anat Rec"},{"key":"r020","doi-asserted-by":"crossref","first-page":"7991","DOI":"10.1016\/S0021-9258(19)42063-2","volume":"249","author":"Bogenhagen","year":"1974","journal-title":"J Biol Chem"},{"key":"r021","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1146\/annurev.bi.53.070184.003041","volume":"53","author":"Clayton","year":"1984","journal-title":"Annu Rev Biochem"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJM198905183202001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:26:49Z","timestamp":1635812809000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJM198905183202001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,5,18]]},"references-count":21,"journal-issue":{"issue":"20","published-print":{"date-parts":[[1989,5,18]]}},"alternative-id":["10.1056\/NEJM198905183202001"],"URL":"https:\/\/doi.org\/10.1056\/nejm198905183202001","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,5,18]]}}}