{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:28:07Z","timestamp":1792268887644,"version":"4.4.0"},"reference-count":67,"publisher":"Massachusetts Medical Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[1998,1]]},"DOI":"10.1056\/nejm199801013380106","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T08:53:28Z","timestamp":1027760008000},"page":"26-34","source":"Crossref","is-referenced-by-count":362,"title":["Management of Life-Threatening Acid\u2013Base Disorders"],"prefix":"10.1056","volume":"338","author":[{"given":"Horacio J.","family":"Adrogu\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaos E.","family":"Madias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1986.62"},{"key":"r002","doi-asserted-by":"crossref","first-page":"C967","DOI":"10.1152\/ajpcell.1990.258.6.C967","volume":"258","author":"Orchard CH","year":"1990","journal-title":"Am J Physiol"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/28.9.1312"},{"key":"r004","first-page":"H825","volume":"244","author":"Kerber RE","year":"1983","journal-title":"Am J Physiol"},{"key":"r005","first-page":"E812","volume":"255","author":"Adrogue HJ","year":"1988","journal-title":"Am J Physiol"},{"key":"r006","first-page":"177","volume":"2","author":"Hood VL","year":"1994","journal-title":"Diabetes Rev"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90182-0"},{"key":"r008","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00005792-198605000-00004","volume":"65","author":"Adrogue HJ","year":"1986","journal-title":"Medicine (Baltimore)"},{"key":"r009","doi-asserted-by":"crossref","first-page":"C277","DOI":"10.1152\/ajpcell.1991.260.2.C277","volume":"260","author":"England BK","year":"1991","journal-title":"Am J Physiol"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117208"},{"key":"r011","first-page":"E735","volume":"263","author":"Reaich D","year":"1992","journal-title":"Am J Physiol"},{"key":"r012","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1152\/jappl.1984.56.6.1640","volume":"56","author":"Madias NE","year":"1984","journal-title":"J Appl Physiol"},{"key":"r013","doi-asserted-by":"crossref","first-page":"615","DOI":"10.7326\/0003-4819-106-4-615","volume":"106","author":"Narins RG","year":"1987","journal-title":"Ann Intern Med"},{"key":"r014","first-page":"8","volume":"14","author":"Faber MD","year":"1994","journal-title":"Semin Nephrol"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110841"},{"key":"r016","doi-asserted-by":"crossref","first-page":"276","DOI":"10.7326\/0003-4819-105-2-276","volume":"105","author":"Stacpoole PW","year":"1986","journal-title":"Ann Intern Med"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.1.314"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198905183202004"},{"key":"r019","first-page":"F1087","volume":"257","author":"Adrogue HJ","year":"1989","journal-title":"Am J Physiol"},{"key":"r020","first-page":"835","volume":"102","author":"Sun JH","year":"1987","journal-title":"Surgery"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199422100-00007"},{"key":"r022","first-page":"H1835","volume":"258","author":"Shapiro JI","year":"1990","journal-title":"Am J Physiol"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.77.1.227"},{"key":"r024","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1097\/00003246-198912000-00015","volume":"17","author":"Kucera RR","year":"1989","journal-title":"Crit Care Med"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.5.1660"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1001\/jama.266.15.2129"},{"key":"r028","doi-asserted-by":"publisher","DOI":"10.1007\/BF00545225"},{"key":"r029","first-page":"86","volume":"2","author":"Cohen RD","year":"1994","journal-title":"Diabetes Rev"},{"key":"r030","unstructured":"Kraut JA, Madias NE. Lactic acidosis. In: Massry SG, Glassock RJ, eds. Textbook of nephrology. 3rd ed. Vol. 1. Baltimore: Williams & Wilkins, 1995:449-57."},{"key":"r031","unstructured":"Hood VL, Tannen RL. Lactic acidosis. In: Adrogu\u00e9 HJ, ed. Contemporary management in critical care. Vol. 1. No. 2. Acid\u2013base and electrolyte disorder. New York: Churchill Livingstone, 1991:1-19."},{"key":"r032","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199006000-00018"},{"key":"r033","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115820"},{"key":"r034","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(81)90212-1"},{"key":"r035","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109431"},{"key":"r036","doi-asserted-by":"crossref","first-page":"492","DOI":"10.7326\/0003-4819-112-7-492","volume":"112","author":"Cooper DJ","year":"1990","journal-title":"Ann Intern Med"},{"key":"r037","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0272-6386(87)80182-8","volume":"10","author":"Madias NE","year":"1987","journal-title":"Am J Kidney Dis"},{"key":"r038","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199211263272204"},{"key":"r039","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90645-2"},{"key":"r040","unstructured":"Adrogu\u00e9 HJ, Tannen RL. Ketoacidosis, hyperosmolar states, and lactic acidosis. In: Kokko JP, Tannen RL, eds. Fluids and electrolytes. 3rd ed. Philadelphia: W.B. Saunders, 1996:643-74."},{"key":"r041","first-page":"F291","volume":"235","author":"Adrogue HJ","year":"1978","journal-title":"Am J Physiol"},{"key":"r042","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198212233072603"},{"key":"r043","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.62"},{"key":"r044","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90003-G"},{"key":"r045","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1988.60"},{"key":"r046","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198807143190206"},{"key":"r047","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197305242882107"},{"key":"r048","first-page":"F613","volume":"259","author":"Chatton JY","year":"1990","journal-title":"Am J Physiol"},{"key":"r049","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1681\/ASN.V181019","volume":"1","author":"Carlisle EJF","year":"1991","journal-title":"J Am Soc Nephrol"},{"key":"r050","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199611150-00030"},{"key":"r051","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198612183152506"},{"key":"r052","unstructured":"Madias NE, Perrone RD. Acid-base disorders in association with renal disease. In: Schrier RW, Gottschalk CW, eds. Diseases of the kidney. 5th ed. Vol. 3. Boston: Little, Brown, 1993:2669-99."},{"key":"r053","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(97)90317-6"},{"key":"r054","unstructured":"Madias NE, Cohen JJ. Respiratory acidosis. In: Cohen JJ, Kassirer JP, eds. Acid-base. Boston: Little, Brown, 1982:307-48."},{"key":"r055","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1152\/jappl.1983.55.4.1187","volume":"55","author":"Madias NE","year":"1983","journal-title":"J Appl Physiol"},{"key":"r056","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1152\/jappl.1985.58.4.1231","volume":"58","author":"Adrogue HJ","year":"1985","journal-title":"J Appl Physiol"},{"key":"r057","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1985.44"},{"key":"r058","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111856"},{"key":"r059","first-page":"F204","volume":"260","author":"Teixeira Da Silva JC","year":"1991","journal-title":"Am J Physiol"},{"key":"r060","unstructured":"Madias NE, Adrogu\u00e9 HJ. Acid-base disturbances in pulmonary medicine. In: Arieff AI, DeFronzo RA, eds. Fluid, electrolyte, and acid-base disorders. 2nd ed. New York: Churchill Livingstone, 1995:223-53."},{"key":"r061","unstructured":"Respiratory pump failure: primary hypercapnia (respiratory acidosis). In: Adrogu\u00e9 HJ, Tobin MJ. Respiratory failure. Cambridge, Mass.: Blackwell Science, 1997:125-34."},{"key":"r062","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1164\/ajrccm.150.6.7952641","volume":"150","author":"Feihl F","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"r063","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199511000-00028"},{"key":"r064","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1164\/ajrccm.152.6.8520744","volume":"152","author":"Amato MBP","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"r065","first-page":"A75","volume":"149","author":"Amato MBP","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"r066","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199605000-00017"},{"key":"r067","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199511000-00007"},{"key":"r068","unstructured":"Adrogu\u00e9 HJ, Madias NE. Mixed acid\u2013base disorders. In: Jacobson HR, Striker GE, Klahr S, eds. The principles and practice of nephrology. 2nd ed. St. Louis: Mosby-Year Book, 1995:953-62."}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJM199801013380106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T06:00:49Z","timestamp":1622008849000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJM199801013380106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1056\/NEJM199801013380106"],"URL":"https:\/\/doi.org\/10.1056\/nejm199801013380106","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1]]}}}