{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:15:25Z","timestamp":1792714525152,"version":"4.5.0"},"reference-count":56,"publisher":"Massachusetts Medical Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2000,8,10]]},"DOI":"10.1056\/nejm200008103430607","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T08:56:19Z","timestamp":1027760179000},"page":"411-419","source":"Crossref","is-referenced-by-count":464,"title":["Islet Amyloid and Type 2 Diabetes Mellitus"],"prefix":"10.1056","volume":"343","author":[{"given":"Jo W.M.","family":"H\u00f6ppener","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Ahr\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelis J.M.","family":"Lips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.1084\/jem.5.5.527"},{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(86)90708-4"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.3109\/13506129409148624"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(88)80922-0"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1038\/385787a0"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198006053022305"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.13.5036"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)81444-5"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.303194.x"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1348"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.3109\/13506129709003838"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.2.241"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1038\/nm0897-855"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1210\/er.19.4.477"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1001\/jama.273.23.1855"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81125-3"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198907063210102"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1007\/BF00500380"},{"key":"r019","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400208"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051060"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1021\/bi981658g"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400803"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.43.12.1457"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1320487"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.14.7283"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.240550006"},{"key":"r027","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051175"},{"key":"r028","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(90)80365-P"},{"key":"r029","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1128\/MCB.12.4.1777","volume":"12","author":"German MS","year":"1992","journal-title":"Mol Cell Biol"},{"key":"r030","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.18.8467"},{"key":"r031","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.5.743"},{"key":"r032","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1998.2510208.x"},{"key":"r033","doi-asserted-by":"publisher","DOI":"10.1007\/BF00452067"},{"key":"r034","doi-asserted-by":"publisher","DOI":"10.1038\/368756a0"},{"key":"r035","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9574"},{"key":"r036","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00894-7"},{"key":"r037","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65360-6"},{"key":"r038","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051138"},{"key":"r039","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.4.1988"},{"key":"r040","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(92)90411-6"},{"key":"r041","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.47.4.612"},{"key":"r042","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.3.491"},{"key":"r043","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(99)90102-6"},{"key":"r044","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7014"},{"key":"r045","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1510341"},{"key":"r046","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199808000-00012"},{"key":"r047","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199706)14:6<472::AID-DIA388>3.0.CO;2-Q"},{"key":"r048","first-page":"A316","volume":"40","author":"Zapecka-Dubno B","year":"1997","journal-title":"Diabetologia"},{"key":"r049","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803263381303"},{"key":"r050","unstructured":"Pepys MB. The Lumleian Lecture: C-reactive protein and amyloidosis: from proteins to drugs? In: Williams G, ed. Horizons in medicine. No. 10. London: Royal College of Physicians of London, 1998:397-414."},{"key":"r051","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199608020-00001"},{"key":"r052","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.8.4109"},{"key":"r053","doi-asserted-by":"publisher","DOI":"10.1038\/nm0798-822"},{"key":"r054","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051079"},{"key":"r055","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9308"},{"key":"r056","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.5.810"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJM200008103430607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T10:45:00Z","timestamp":1501584300000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJM200008103430607"}},"subtitle":[],"editor":[{"given":"Franklin H.","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2000,8,10]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,8,10]]}},"alternative-id":["10.1056\/NEJM200008103430607"],"URL":"https:\/\/doi.org\/10.1056\/nejm200008103430607","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,8,10]]}}}