{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:18:25Z","timestamp":1792819105442,"version":"4.5.0"},"reference-count":39,"publisher":"Massachusetts Medical Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2001,2,8]]},"DOI":"10.1056\/nejm200102083440602","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:49:14Z","timestamp":1027774154000},"page":"403-409","source":"Crossref","is-referenced-by-count":1187,"title":["Efficacy of a Pneumococcal Conjugate Vaccine against Acute Otitis Media"],"prefix":"10.1056","volume":"344","author":[{"given":"Juhani","family":"Eskola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terhi","family":"Kilpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arto","family":"Palmu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jukka","family":"Jokinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervi","family":"Eerola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaason","family":"Haapakoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elja","family":"Herva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aino","family":"Takala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"K\u00e4yhty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka","family":"Karma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kohberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Lockhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Siber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Helena","family":"M\u00e4kel\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506083322307"},{"key":"r002","unstructured":"Freid VM, Makuc DM, Rooks RN. Ambulatory health care visits by children: principal diagnosis and place of visit. Vital and health statistics. Series 13. No. 137. Washington, D.C.: Government Printing Office, 1998. (DHHS publication no. (PHS) 98-1798.)"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/162.3.685"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1997.tb14848.x"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1080\/08035259950169585"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(96)70243-7"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199702001-00003"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1542\/peds.105.6.e72"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81051-0"},{"key":"r010","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3109\/inf.1981.13.issue-3.04","volume":"13","author":"Luotonen J","year":"1981","journal-title":"Scand J Infect Dis"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199208001-00002"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199704000-00029"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(85)80081-8"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.4.885"},{"key":"r015","unstructured":"Block SL, Hendrick JA, Harrison CJ. Pneumococcal serotypes from acute otitis media in rural Kentucky. In: Program and abstracts of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, September 26\u201329, 1999. Washington, D.C.: American Society for Microbiology, 1999:677. abstract."},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91989-3"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/3.Supplement_1.S113"},{"key":"r018","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1542\/peds.73.1.79","volume":"73","author":"Howie VM","year":"1984","journal-title":"Pediatrics"},{"key":"r019","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/149.6.861"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/172.5.1273"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199602000-00009"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.4.604"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199909000-00004"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199604000-00010"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199803000-00008"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00048-1"},{"key":"r027","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199712000-00007"},{"key":"r028","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(99)00393-X"},{"key":"r029","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.6.1271"},{"key":"r030","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199711000-00011"},{"key":"r031","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)65585-7"},{"key":"r032","doi-asserted-by":"publisher","DOI":"10.1086\/315009"},{"key":"r033","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200003000-00003"},{"key":"r034","first-page":"1","volume":"129","author":"Karma P","year":"1987","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"key":"r035","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1128\/JCM.11.2.135-140.1980","volume":"11","author":"Leinonen MK","year":"1980","journal-title":"J Clin Microbiol"},{"key":"r036","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176345976"},{"key":"r037","first-page":"213","volume":"53","author":"Eerola M","year":"1989","journal-title":"Bull Int Stat Inst"},{"key":"r038","unstructured":"Breslow NE, Day NE. Statistical methods in cancer research. Vol. 2. The design and analysis of cohort studies. Lyon, France: International Agency for Research on Cancer, 1987. (IARC scientific publications no. 82.)"},{"key":"r039","unstructured":"Black S, Shinefield H, Ray P, et al. Efficacy of heptavalent conjugate pneumococcal vaccine (Wyeth Lederle) in 37,000 infants and children: impact on pneumonia, otitis media, and an update on invasive disease \u2014 results of the Northern California Kaiser Permanente Efficacy Trial. In: Program and abstracts of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Francisco, September 26\u201329, 1999. Washington, D.C.: American Society for Microbiology, 1999:379. abstract."}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJM200102083440602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T20:12:41Z","timestamp":1682280761000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJM200102083440602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2,8]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,2,8]]}},"alternative-id":["10.1056\/NEJM200102083440602"],"URL":"https:\/\/doi.org\/10.1056\/nejm200102083440602","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2,8]]}}}