{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:03:44Z","timestamp":1791324224371,"version":"4.3.1"},"reference-count":97,"publisher":"Massachusetts Medical Society","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2001,5,17]]},"DOI":"10.1056\/nejm200105173442007","type":"journal-article","created":{"date-parts":[[2002,7,27]],"date-time":"2002-07-27T12:56:19Z","timestamp":1027774579000},"page":"1527-1535","source":"Crossref","is-referenced-by-count":432,"title":["Oral Contraceptives and the Risk of Venous Thrombosis"],"prefix":"10.1056","volume":"344","author":[{"given":"Jan P.","family":"Vandenbroucke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Rosing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitty W.M.","family":"Bloemenkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Middeldorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans M.","family":"Helmerhorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonno N.","family":"Bouma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits R.","family":"Rosendaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/S0002-9378(87)80129-1","volume":"157","author":"Bonnar J","year":"1987","journal-title":"Am J Obstet Gynecol"},{"key":"r002","first-page":"40","volume":"34","author":"Stubblefield PG","year":"1989","journal-title":"Int J Fertil"},{"key":"r003","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1055\/s-0038-1657546","volume":"78","author":"Kluft C","year":"1997","journal-title":"Thromb Haemost"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(98)00020-1"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(98)00016-X"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/5.6.721"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-0620(94)80051-0"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90286-0"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198109103051104"},{"key":"r010","first-page":"1","volume":"877","year":"1998","journal-title":"WHO Tech Rep Ser"},{"key":"r011","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1136\/bmj.316.7136.984","volume":"316","author":"Hannaford PC","year":"1998","journal-title":"BMJ"},{"key":"r012","first-page":"91","volume":"69","author":"Helmrich SP","year":"1987","journal-title":"Obstet Gynecol"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6519.526"},{"key":"r014","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0140-6736(95)91926-0","volume":"346","year":"1995","journal-title":"Lancet"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91928-7"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(96)00112-6"},{"key":"r017","unstructured":"Colman RW, Hirsch J, Marder VJ, Salzman EW, eds. Hemostasis and thrombosis: basic principles and clinical practice. 3rd ed. Philadelphia: J.B. Lippincott, 1994:1283-4."},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5599.199"},{"key":"r019","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/oxfordjournals.aje.a112148","volume":"102","author":"Stolley PD","year":"1975","journal-title":"Am J Epidemiol"},{"key":"r020","first-page":"315","volume":"10","author":"Realini JP","year":"1997","journal-title":"J Am Board Fam Pract"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.1.65"},{"key":"r022","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/S0140-6736(95)91927-9","volume":"346","year":"1995","journal-title":"Lancet"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91929-5"},{"key":"r024","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/bmj.312.7023.83","volume":"312","author":"Spitzer WO","year":"1996","journal-title":"BMJ"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)07496-X"},{"key":"r026","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1136\/bmj.316.7137.1090","volume":"316","author":"Farmer RDT","year":"1998","journal-title":"BMJ"},{"key":"r027","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1161\/01.ATV.19.3.700","volume":"19","author":"Martinelli I","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"r028","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1998.00310.x"},{"key":"r029","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1055\/s-0037-1614213","volume":"79","author":"Andersen BS","year":"1998","journal-title":"Thromb Haemost"},{"key":"r030","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(98)00033-X"},{"key":"r031","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(99)00011-6"},{"key":"r032","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01257-X"},{"key":"r033","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)04394-9"},{"key":"r034","first-page":"19","volume":"44","author":"Burnhill MS","year":"1999","journal-title":"Int J Fertil Womens Med"},{"key":"r035","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02382-5"},{"key":"r036","first-page":"547","volume":"347","author":"Poulter NR","year":"1996","journal-title":"Lancet"},{"key":"r037","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70289-8"},{"key":"r038","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.6.1822"},{"key":"r039","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02369-2"},{"key":"r040","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7255.190"},{"key":"r041","doi-asserted-by":"publisher","DOI":"10.1053\/ob.1998.v179.a93059"},{"key":"r042","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.6.1493"},{"key":"r043","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.4.817"},{"key":"r044","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91921-X"},{"key":"r045","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1136\/bmj.312.7023.68","volume":"312","author":"McPherson K","year":"1996","journal-title":"BMJ"},{"key":"r046","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(98)00014-6"},{"key":"r047","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1136\/bmj.319.7213.795","volume":"319","author":"O'Brien PA","year":"1999","journal-title":"BMJ"},{"key":"r048","first-page":"12","volume":"25","year":"1999","journal-title":"Curr Probl Pharmacovigilance"},{"key":"r049","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.3.1004"},{"key":"r050","doi-asserted-by":"publisher","DOI":"10.1038\/369064a0"},{"key":"r051","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91803-5"},{"key":"r052","doi-asserted-by":"publisher","DOI":"10.1001\/jama.277.16.1305"},{"key":"r053","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1182\/blood.V85.6.1504.bloodjournal8561504","volume":"85","author":"Rosendaal FR","year":"1995","journal-title":"Blood"},{"key":"r054","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90192-2"},{"key":"r055","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011293232202"},{"key":"r056","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1182\/blood.V85.10.2756.bloodjournal85102756","volume":"85","author":"Koster T","year":"1995","journal-title":"Blood"},{"key":"r057","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1055\/s-0038-1642457","volume":"71","author":"Pabinger I","year":"1994","journal-title":"Thromb Haemost"},{"key":"r058","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1055\/s-0037-1614442","volume":"81","author":"Simioni P","year":"1999","journal-title":"Thromb Haemost"},{"key":"r059","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199110000-00015"},{"key":"r060","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1182\/blood.V88.10.3698.bloodjournal88103698","volume":"88","author":"Poort SR","year":"1996","journal-title":"Blood"},{"key":"r061","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1055\/s-0037-1615049","volume":"79","author":"Rosendaal FR","year":"1998","journal-title":"Thromb Haemost"},{"key":"r062","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.1.49"},{"key":"r063","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90166-3"},{"key":"r064","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-0037-1613747","volume":"83","author":"Kraaijenhagen RA","year":"2000","journal-title":"Thromb Haemost"},{"key":"r065","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)91955-2"},{"key":"r066","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1055\/s-0037-1614323","volume":"82","author":"Bloemenkamp KWM","year":"1999","journal-title":"Thromb Haemost"},{"key":"r067","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1055\/s-0037-1613876","volume":"83","author":"Robert A","year":"2000","journal-title":"Thromb Haemost"},{"key":"r068","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1055\/s-0037-1615132","volume":"80","author":"Bouma BN","year":"1998","journal-title":"Thromb Haemost"},{"key":"r069","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1055\/s-0037-1613959","volume":"84","author":"Middeldorp S","year":"2000","journal-title":"Thromb Haemost"},{"key":"r070","doi-asserted-by":"crossref","first-page":"18735","DOI":"10.1016\/S0021-9258(17)32228-7","volume":"269","author":"Shen L","year":"1994","journal-title":"J Biol Chem"},{"key":"r071","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1055\/s-0038-1650556","volume":"76","author":"Varadi K","year":"1996","journal-title":"Thromb Haemost"},{"key":"r072","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199410000-00030"},{"key":"r073","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05323.x"},{"key":"r074","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1055\/s-0038-1653788","volume":"73","author":"Henkens CMA","year":"1995","journal-title":"Thromb Haemost"},{"key":"r075","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1055\/s-0037-1614599","volume":"81","author":"Lowe GD","year":"1999","journal-title":"Thromb Haemost"},{"key":"r076","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.192707.x"},{"key":"r077","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)63015-2"},{"key":"r078","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)06092-4"},{"key":"r079","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-996021"},{"key":"r080","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1182\/blood.V93.4.1271","volume":"93","author":"de Visser MCH","year":"1999","journal-title":"Blood"},{"key":"r081","doi-asserted-by":"crossref","first-page":"643","DOI":"10.7326\/0003-4819-130-8-199904200-00004","volume":"130","author":"Rodeghiero F","year":"1999","journal-title":"Ann Intern Med"},{"key":"r082","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1055\/s-0037-1613960","volume":"84","author":"Tans G","year":"2000","journal-title":"Thromb Haemost"},{"key":"r083","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1055\/s-0037-1613959","volume":"84","author":"Meijers JCM","year":"2000","journal-title":"Thromb Haemost"},{"key":"r084","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.24.14477"},{"key":"r085","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119412"},{"key":"r086","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1182\/blood.V95.9.2855.009k02_2855_2859","volume":"95","author":"van Tilburg NH","year":"2000","journal-title":"Blood"},{"key":"r087","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0002-9378(90)90583-S","volume":"163","author":"Kuhl H","year":"1990","journal-title":"Am J Obstet Gynecol"},{"key":"r088","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(98)00019-5"},{"key":"r090","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1136\/bmj.315.7121.1502","volume":"315","author":"Heinemann LAJ","year":"1997","journal-title":"BMJ"},{"key":"r091","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1136\/bmj.318.7198.1579","volume":"318","author":"Dunn N","year":"1999","journal-title":"BMJ"},{"key":"r092","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5901.215"},{"key":"r093","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(98)00041-9"},{"key":"r094","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/bmj.312.7025.198","volume":"312","author":"Campbell B","year":"1996","journal-title":"BMJ"},{"key":"r095","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1136\/bmj.313.7065.1127","volume":"313","author":"Vandenbroucke JP","year":"1996","journal-title":"BMJ"},{"key":"r096","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-125-1-199607010-00001","volume":"125","author":"Prandoni P","year":"1996","journal-title":"Ann Intern Med"},{"key":"r097","first-page":"317","volume":"91","author":"Szucs T","year":"1996","journal-title":"Med Klin"},{"key":"r098","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1182\/blood.V88.11.4205.4205","volume":"88","author":"Lensen RPM","year":"1996","journal-title":"Blood"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJM200105173442007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T10:22:21Z","timestamp":1622024541000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJM200105173442007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5,17]]},"references-count":97,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2001,5,17]]}},"alternative-id":["10.1056\/NEJM200105173442007"],"URL":"https:\/\/doi.org\/10.1056\/nejm200105173442007","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5,17]]}}}