{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T15:52:22Z","timestamp":1713973942044},"reference-count":23,"publisher":"Massachusetts Medical Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2021,2,11]]},"DOI":"10.1056\/nejmcpc2027088","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T22:20:14Z","timestamp":1612995614000},"page":"563-574","source":"Crossref","is-referenced-by-count":0,"title":["Case 4-2021: A 70-Year-Old Woman with Dyspnea on Exertion and Abnormal Findings on Chest Imaging"],"prefix":"10.1056","volume":"384","author":[{"given":"Richard M.","family":"Schwartzstein","sequence":"first","affiliation":[{"name":"From the Department of Medicine, Beth Israel Deaconess Medical Center (R.M.S.), the Departments of Medicine (B.D.M., J.G.), Radiology (A.S.), Surgery (Y.L.C.), and Pathology (L.P.H.), Massachusetts General Hospital, and the Departments of Medicine (B.D.M., J.G.), Radiology (A.S.), Surgery (Y.L.C.), and Pathology (L.P.H.), Harvard Medical School \u2014 all in Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin D.","family":"Medoff","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Beth Israel Deaconess Medical Center (R.M.S.), the Departments of Medicine (B.D.M., J.G.), Radiology (A.S.), Surgery (Y.L.C.), and Pathology (L.P.H.), Massachusetts General Hospital, and the Departments of Medicine (B.D.M., J.G.), Radiology (A.S.), Surgery (Y.L.C.), and Pathology (L.P.H.), Harvard Medical School \u2014 all in Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amita","family":"Sharma","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Beth Israel Deaconess Medical Center (R.M.S.), the Departments of Medicine (B.D.M., J.G.), Radiology (A.S.), Surgery (Y.L.C.), and Pathology (L.P.H.), Massachusetts General Hospital, and the Departments of Medicine (B.D.M., J.G.), Radiology (A.S.), Surgery (Y.L.C.), and Pathology (L.P.H.), Harvard Medical School \u2014 all in Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolonda L.","family":"Colson","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Beth Israel Deaconess Medical Center (R.M.S.), the Departments of Medicine (B.D.M., J.G.), Radiology (A.S.), Surgery (Y.L.C.), and Pathology (L.P.H.), Massachusetts General Hospital, and the Departments of Medicine (B.D.M., J.G.), Radiology (A.S.), Surgery (Y.L.C.), and Pathology (L.P.H.), Harvard Medical School \u2014 all in Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Gainor","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Beth Israel Deaconess Medical Center (R.M.S.), the Departments of Medicine (B.D.M., J.G.), Radiology (A.S.), Surgery (Y.L.C.), and Pathology (L.P.H.), Massachusetts General Hospital, and the Departments of Medicine (B.D.M., J.G.), Radiology (A.S.), Surgery (Y.L.C.), and Pathology (L.P.H.), Harvard Medical School \u2014 all in Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lida P.","family":"Hariri","sequence":"additional","affiliation":[{"name":"From the Department of Medicine, Beth Israel Deaconess Medical Center (R.M.S.), the Departments of Medicine (B.D.M., J.G.), Radiology (A.S.), Surgery (Y.L.C.), and Pathology (L.P.H.), Massachusetts General Hospital, and the Departments of Medicine (B.D.M., J.G.), Radiology (A.S.), Surgery (Y.L.C.), and Pathology (L.P.H.), Harvard Medical School \u2014 all in Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"150","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1164\/ajrccm\/140.4.1021","article-title":"Distinguishable sensations of breathlessness induced in normal volunteers.","volume":"140","author":"Simon PM","year":"1989","unstructured":"Simon PM, Schwartzstein RM, Weiss JW, et al. Distinguishable sensations of breathlessness induced in normal volunteers. Am Rev Respir Dis 1989;140:1021-1027.2508520","journal-title":"Am Rev Respir Dis"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1164\/ajrccm\/142.5.1009","article-title":"Distinguishable types of dyspnea in patients with shortness of breath.","volume":"142","author":"Simon PM","year":"1990","unstructured":"Simon PM, Schwartzstein RM, Weiss JW, Fencl V, Teghtsoonian M, Weinberger SE. Distinguishable types of dyspnea in patients with shortness of breath. Am Rev Respir Dis 1990;142:1009-1014.2240820","journal-title":"Am Rev Respir Dis"},{"key":"e_1_3_3_4_2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1164\/ajrccm.162.2.9907138","article-title":"Quality of dyspnea in bronchoconstriction differs from external resistive loads.","volume":"162","author":"Moy ML","year":"2000","unstructured":"Moy ML, Woodrow Weiss J, Sparrow D, Israel E, Schwartzstein RM. Quality of dyspnea in bronchoconstriction differs from external resistive loads. Am J Respir Crit Care Med 2000;162:451-455.10934069","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1164\/ajrccm.158.3.9707088","article-title":"Language of dyspnea in assessment of patients with acute asthma treated with nebulized albuterol.","volume":"158","author":"Moy ML","year":"1998","unstructured":"Moy ML, Lantin ML, Harver A, Schwartzstein RM. Language of dyspnea in assessment of patients with acute asthma treated with nebulized albuterol. Am J Respir Crit Care Med 1998;158:749-753.9731000","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1164\/ajrccm.154.5.8912748","article-title":"Descriptors of breathlessness in cardiorespiratory diseases.","volume":"154","author":"Mahler DA","year":"1996","unstructured":"Mahler DA, Harver A, Lentine T, Scott JA, Beck K, Schwartzstein RM. Descriptors of breathlessness in cardiorespiratory diseases. Am J Respir Crit Care Med 1996;154:1357-1363.8912748","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1513\/pats.200611-159CC","article-title":"Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable.","volume":"4","author":"O\u2019Donnell DE","year":"2007","unstructured":"O\u2019Donnell DE, Banzett RB, Carrieri-Kohlman V, et al. Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable. Proc Am Thorac Soc 2007;4:145-168.17494725","journal-title":"Proc Am Thorac Soc"},{"key":"e_1_3_3_8_2","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1161\/CIRCHEARTFAILURE.109.879684","article-title":"Influence of locomotor muscle metaboreceptor stimulation on the ventilatory response to exercise in heart failure.","volume":"3","author":"Olson TP","year":"2010","unstructured":"Olson TP, Joyner MJ, Johnson BD. Influence of locomotor muscle metaboreceptor stimulation on the ventilatory response to exercise in heart failure. Circ Heart Fail 2010;3:212-219.20061520","journal-title":"Circ Heart Fail"},{"key":"e_1_3_3_9_2","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1056\/NEJMra1411863","article-title":"The asthma\u2013COPD overlap syndrome.","volume":"373","author":"Postma DS","year":"2015","unstructured":"Postma DS, Rabe KF. The asthma\u2013COPD overlap syndrome. N Engl J Med 2015;373:1241-1249.26398072","journal-title":"N Engl J Med"},{"key":"e_1_3_3_10_2","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1148\/rg.2015140308","article-title":"Mosaic attenuation: etiology, methods of differentiation, and pitfalls.","volume":"35","author":"Kligerman SJ","year":"2015","unstructured":"Kligerman SJ, Henry T, Lin CT, Franks TJ, Galvin JR. Mosaic attenuation: etiology, methods of differentiation, and pitfalls. Radiographics 2015;35:1360-1380.26274445","journal-title":"Radiographics"},{"key":"e_1_3_3_11_2","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1183\/13993003.01954-2015","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia syndrome.","volume":"47","author":"Rossi G","year":"2016","unstructured":"Rossi G, Cavazza A, Spagnolo P, et al. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia syndrome. Eur Respir J 2016;47:1829-1841.27076588","journal-title":"Eur Respir J"},{"key":"e_1_3_3_12_2","doi-asserted-by":"crossref","first-page":"975","DOI":"10.12659\/AJCR.904468","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: a case report and review of the literature.","volume":"18","author":"Koliakos E","year":"2017","unstructured":"Koliakos E, Thomopoulos T, Abbassi Z, Duc C, Christodoulou M. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: a case report and review of the literature. Am J Case Rep 2017;18:975-979.28890532","journal-title":"Am J Case Rep"},{"key":"e_1_3_3_13_2","unstructured":"Travis WD Brambilla E Burke AP Marx A Nicholson OG eds. WHO classification of tumours of the lung pleura thymus and heart. 4th ed. Geneva: World Health Organization 2015."},{"key":"e_1_3_3_14_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1164\/rccm.201010-1685PP","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: a systematic overview.","volume":"184","author":"Nassar AA","year":"2011","unstructured":"Nassar AA, Jaroszewski DE, Helmers RA, Colby TV, Patel BM, Mookadam F. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: a systematic overview. Am J Respir Crit Care Med 2011;184:8-16.21471097","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_3_3_15_2","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1056\/NEJM199210293271806","article-title":"Idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease.","volume":"327","author":"Aguayo SM","year":"1992","unstructured":"Aguayo SM, Miller YE, Waldron JA Jr, et al. Idiopathic diffuse hyperplasia of pulmonary neuroendocrine cells and airways disease. N Engl J Med 1992;327:1285-1288.1406819","journal-title":"N Engl J Med"},{"key":"e_1_3_3_16_2","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1378\/chest.06-2788","article-title":"Significance of multiple carcinoid tumors and tumorlets in surgical lung specimens: analysis of 28 patients.","volume":"131","author":"Aubry M-C","year":"2007","unstructured":"Aubry M-C, Thomas CF Jr, Jett JR, Swensen SJ, Myers JL. Significance of multiple carcinoid tumors and tumorlets in surgical lung specimens: analysis of 28 patients. Chest 2007;131:1635-1643.17400673","journal-title":"Chest"},{"key":"e_1_3_3_17_2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00408-015-9755-1","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia of the lung (DIPNECH): current best evidence.","volume":"193","author":"Wirtschafter E","year":"2015","unstructured":"Wirtschafter E, Walts AE, Liu ST, Marchevsky AM. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia of the lung (DIPNECH): current best evidence. Lung 2015;193:659-667.26104490","journal-title":"Lung"},{"key":"e_1_3_3_18_2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1136\/thx.2006.063065","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease.","volume":"62","author":"Davies SJ","year":"2007","unstructured":"Davies SJ, Gosney JR, Hansell DM, et al. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: an under-recognised spectrum of disease. Thorax 2007;62:248-252.17099078","journal-title":"Thorax"},{"key":"e_1_3_3_19_2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00408-015-9754-2","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) and the role of somatostatin analogs: a case series.","volume":"193","author":"Chauhan A","year":"2015","unstructured":"Chauhan A, Ramirez RA. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) and the role of somatostatin analogs: a case series. Lung 2015;193:653-657.26112453","journal-title":"Lung"},{"key":"e_1_3_3_20_2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/LBR.0000000000000098","article-title":"Double lung transplantation for diffuse idiopathic pulmonary neuroendocrine cell hyperplasia.","volume":"21","author":"Zhou H","year":"2014","unstructured":"Zhou H, Ge Y, Janssen B, et al. Double lung transplantation for diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. J Bronchology Interv Pulmonol 2014;21:342-345.25321455","journal-title":"J Bronchology Interv Pulmonol"},{"key":"e_1_3_3_21_2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00408-018-0149-z","article-title":"Management of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: review and a single center experience.","volume":"196","author":"Myint ZW","year":"2018","unstructured":"Myint ZW, McCormick J, Chauhan A, Behrens E, Anthony LB. Management of diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: review and a single center experience. Lung 2018;196:577-581.30167840","journal-title":"Lung"},{"key":"e_1_3_3_22_2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.chest.2020.01.031","article-title":"Somatostatin analogs improve respiratory symptoms in patients with diffuse idiopathic neuroendocrine cell hyperplasia.","volume":"158","author":"Al-Toubah T","year":"2020","unstructured":"Al-Toubah T, Strosberg J, Halfdanarson TR, et al. Somatostatin analogs improve respiratory symptoms in patients with diffuse idiopathic neuroendocrine cell hyperplasia. Chest 2020;158:401-405.32059961","journal-title":"Chest"},{"key":"e_1_3_3_23_2","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/cncr.26200","article-title":"Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia and the associated lung neuroendocrine tumors: clinical experience with a rare entity.","volume":"118","author":"Gorshtein A","year":"2012","unstructured":"Gorshtein A, Gross DJ, Barak D, et al. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia and the associated lung neuroendocrine tumors: clinical experience with a rare entity. Cancer 2012;118:612-619.21751183","journal-title":"Cancer"},{"key":"e_1_3_3_24_2","unstructured":"National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: neuroendocrine and adrenal tumors. 2020 (https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/neuroendocrine.pdf)."}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMcpc2027088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:25:40Z","timestamp":1711499140000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMcpc2027088"}},"subtitle":[],"editor":[{"given":"Richard C.","family":"Cabot","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Eric S.","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Virginia M.","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"David M.","family":"Dudzinski","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Meridale V.","family":"Baggett","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Dennis C.","family":"Sgroi","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Jo-Anne O.","family":"Shepard","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Kathy M.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Matthew B.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Emily K.","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]},{"given":"Tara","family":"Corpuz","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,2,11]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,2,11]]}},"alternative-id":["10.1056\/NEJMcpc2027088"],"URL":"https:\/\/doi.org\/10.1056\/nejmcpc2027088","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,11]]}}}