{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:21:45Z","timestamp":1792012905334,"version":"4.4.0"},"reference-count":20,"publisher":"Massachusetts Medical Society","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2005,4,21]]},"DOI":"10.1056\/nejmoa041810","type":"journal-article","created":{"date-parts":[[2005,4,20]],"date-time":"2005-04-20T17:13:25Z","timestamp":1114017205000},"page":"1655-1666","source":"Crossref","is-referenced-by-count":206,"title":["Leflunomide or Methotrexate for Juvenile Rheumatoid Arthritis"],"prefix":"10.1056","volume":"352","author":[{"given":"Earl","family":"Silverman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Mouy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Spiegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence K.","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rotraud K.","family":"Saurenmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pekka","family":"Lahdenne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Horneff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Immaculada","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona S.","family":"Szer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke","family":"Strand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","first-page":"1520","volume":"29","author":"Manners PJ","year":"2002","journal-title":"J Rheumatol"},{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199204163261602"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003163421103"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1002\/art.10710"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199805)41:5<808::AID-ART6>3.0.CO;2-T"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200008)43:8<1849::AID-ANR22>3.0.CO;2-F"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1002\/art.10683"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1080\/030097499750042236"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.7.689"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200109)44:9<1984::AID-ART346>3.0.CO;2-B"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.21.2542"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200003)43:3<495::AID-ANR4>3.0.CO;2-U"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)09403-3"},{"key":"r015","first-page":"195","volume":"20","author":"Brewer EJ","year":"1977","journal-title":"Arthritis Rheum"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199707)40:7<1202::AID-ART3>3.0.CO;2-R"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200108)44:8<1768::AID-ART312>3.0.CO;2-Q"},{"key":"r018","first-page":"S1","volume":"19","author":"Ruperto N","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"r019","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780371209"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2003.11.017"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200241060-00003"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa041810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T16:00:30Z","timestamp":1478102430000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJMoa041810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,21]]},"references-count":20,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2005,4,21]]}},"alternative-id":["10.1056\/NEJMoa041810"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa041810","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,21]]}}}