{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:27:24Z","timestamp":1791289644298,"version":"4.3.0"},"reference-count":39,"publisher":"Massachusetts Medical Society","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2009,11,19]]},"DOI":"10.1056\/nejmoa0905506","type":"journal-article","created":{"date-parts":[[2009,9,23]],"date-time":"2009-09-23T22:42:40Z","timestamp":1253745760000},"page":"2046-2055","source":"Crossref","is-referenced-by-count":687,"title":["Combined Immunodeficiency Associated with\n                    <i>DOCK8<\/i>\n                    Mutations"],"prefix":"10.1056","volume":"361","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremiah C.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian T.","family":"Lamborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra F.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huie","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Favreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen F.","family":"Matthews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joie","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulbu","family":"Uzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Holland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen C.","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.11.012"},{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2008.01.009"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32831ac557"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.113.4.495"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(03)00449-9"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2008.01.005"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1097\/01.GIM.0000105752.80592.A3"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26121"},{"key":"r009","first-page":"91","volume":"119","author":"van der Burg M","year":"2009","journal-title":"J Clin Invest"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.12.031"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1007\/BF00917017"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19961016)65:2<167::AID-AJMG17>3.0.CO;2-O"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1662"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1038\/nri2336"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.10.023"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.06.095"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200012000-00008"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1038\/nature06764"},{"key":"r019","doi-asserted-by":"publisher","DOI":"10.1086\/302547"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.07.003"},{"key":"r021","unstructured":"Custer JW, Rau RE, eds. The Harriet Lane handbook: a manual for pediatric house officers. 18th ed. Philadelphia: Elsevier Mosby, 2009."},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04195.x"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.76.050106.093909"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02671"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1038\/35090591"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(03)00169-9"},{"key":"r027","doi-asserted-by":"publisher","DOI":"10.1038\/ni1506"},{"key":"r028","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061780"},{"key":"r029","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073687"},{"key":"r030","doi-asserted-by":"publisher","DOI":"10.1038\/nature06096"},{"key":"r031","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.04.037"},{"key":"r032","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080321"},{"key":"r033","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.09.009"},{"key":"r034","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.05.007"},{"key":"r035","first-page":"321","volume":"28","author":"Takahashi K","year":"2006","journal-title":"Int J Oncol"},{"key":"r036","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-008-9644-z"},{"key":"r037","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2007.10.011"},{"key":"r038","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gam045"},{"key":"r039","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.7.080505.115618"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa0905506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T16:09:38Z","timestamp":1478102978000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJMoa0905506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,19]]},"references-count":39,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2009,11,19]]}},"alternative-id":["10.1056\/NEJMoa0905506"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa0905506","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1168490.630679","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,19]]}}}