{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:36:40Z","timestamp":1793054200362,"version":"4.5.0"},"reference-count":25,"publisher":"Massachusetts Medical Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2010,9,16]]},"DOI":"10.1056\/nejmoa0909883","type":"journal-article","created":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T17:03:51Z","timestamp":1284570231000},"page":"1128-1138","source":"Crossref","is-referenced-by-count":2277,"title":["Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease"],"prefix":"10.1056","volume":"363","author":[{"given":"John R.","family":"Hurst","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Vestbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Anzueto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Locantore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"M\u00fcllerova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Tal-Singer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Lomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvar","family":"Agusti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"MacNee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Calverley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Rennard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiel F.M.","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jadwiga A.","family":"Wedzicha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1164\/ajrccm.164.3.2010017","volume":"164","author":"Kanner RE","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.10.847"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200408-1054OC"},{"key":"r004","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1164\/ajrccm.157.5.9709032","volume":"157","author":"Seemungal TA","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.040527"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.2_suppl.5S"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.04.00014304"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.041806"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063070"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805800"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00111707"},{"key":"r013","first-page":"45","volume":"119","author":"Comstock GW","year":"1979","journal-title":"Am Rev Respir Dis"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61382-8"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.7.581"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-0702"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10245"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"r020","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1164\/ajrccm.164.9.2105011","volume":"164","author":"Seemungal T","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.2.114"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.4.1096"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1159\/000067462"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00009307"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2062"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2006.064410"},{"key":"r027","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200708-1290OC"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa0909883","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T16:24:55Z","timestamp":1559665495000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJMoa0909883"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,16]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,9,16]]}},"alternative-id":["10.1056\/NEJMoa0909883"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa0909883","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.5519956.5491057","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,16]]}}}