{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:50:50Z","timestamp":1790495450941,"version":"4.1.0"},"reference-count":29,"publisher":"Massachusetts Medical Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2011,3,24]]},"DOI":"10.1056\/nejmoa1008378","type":"journal-article","created":{"date-parts":[[2011,3,23]],"date-time":"2011-03-23T21:09:19Z","timestamp":1300914559000},"page":"1093-1103","source":"Crossref","is-referenced-by-count":489,"title":["Tiotropium versus Salmeterol for the Prevention of Exacerbations of COPD"],"prefix":"10.1056","volume":"364","author":[{"given":"Claus","family":"Vogelmeier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Hederer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Glaab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen P.M.H.","family":"Rutten-van M\u00f6lken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai M.","family":"Beeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus F.","family":"Rabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo M.","family":"Fabbri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0912556"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.57.10.847"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.040527"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61382-8"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909883"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063070"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00269802"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.4.957"},{"key":"r011","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1164\/ajrccm.163.5.9903053","volume":"163","author":"Rennard SI","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805800"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2005.02.013"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.58.5.399"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp0912651"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp0908797"},{"key":"r017","first-page":"119","volume":"4","author":"Beeh KM","year":"2009","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"r018","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1183\/09041950.005s1693","volume":"16","author":"Quanjer PH","year":"1993","journal-title":"Eur Respir J Suppl"},{"key":"r019","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1164\/ajrccm.152.3.7663792","volume":"152","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00122608"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2009.06.002"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.1.258"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12459-2"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2009.125435"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.034280"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1378\/chest.124.4.1350"},{"key":"r027","doi-asserted-by":"crossref","first-page":"317","DOI":"10.7326\/0003-4819-143-5-200509060-00007","volume":"143","author":"Niewoehner DE","year":"2005","journal-title":"Ann Intern Med"},{"key":"r028","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0011"},{"key":"r029","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2147\/COPD.S4802","volume":"4","author":"Kesten S","year":"2009","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"r030","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.6.1817"},{"key":"r031","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136077"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1008378","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T11:36:17Z","timestamp":1560080177000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJMoa1008378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,24]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,3,24]]}},"alternative-id":["10.1056\/NEJMoa1008378"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1008378","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,24]]}}}