{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:14:05Z","timestamp":1792066445079,"version":"4.4.0"},"reference-count":34,"publisher":"Massachusetts Medical Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2011,7,14]]},"DOI":"10.1056\/nejmoa1100066","type":"journal-article","created":{"date-parts":[[2011,4,27]],"date-time":"2011-04-27T17:00:58Z","timestamp":1303923658000},"page":"127-138","source":"Crossref","is-referenced-by-count":593,"title":["<i>IRF8<\/i>\n                    Mutations and Human Dendritic-Cell Immunodeficiency"],"prefix":"10.1056","volume":"365","author":[{"given":"Sophie","family":"Hambleton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacinta","family":"Bustamante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venetia","family":"Bigley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Boisson-Dupuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anny","family":"Fortin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzlifah","family":"Haniffa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Ceron-Gutierrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris M.","family":"Bacon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Menon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Trouillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Carey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Ginhoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laia","family":"Alsina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.","family":"Zumwalt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Fei","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinakantha","family":"Kumararatne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Hubeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Feinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh","family":"Al-Muhsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Cant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Abel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Chaussabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Doffinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Talesnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anete","family":"Grumach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Abarca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewton","family":"Moraes-Vasconcelos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Burk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Berghuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Geissmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Collin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Laurent","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.11.012"},{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1126\/science.1142963"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00449-4"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1126\/science.1178331"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2128"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91421-8"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.20.081501.125851"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090400"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2009.00868.x"},{"key":"r010","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1182\/blood.V94.11.3764","volume":"94","author":"Scheller M","year":"1999","journal-title":"Blood"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00016-9"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1088"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021263"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-07-100750"},{"key":"r015","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.4049\/jimmunol.170.3.1131","volume":"170","author":"Tsujimura H","year":"2003","journal-title":"J Immunol"},{"key":"r016","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.4049\/jimmunol.179.4.2467","volume":"179","author":"Turcotte K","year":"2007","journal-title":"J Immunol"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0800680"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-208629"},{"key":"r019","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101459"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81348-3"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.18.5028"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1038\/nri2784"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1038\/ni852"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1126\/science.1194637"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707704200"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01546-08"},{"key":"r027","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.05.289"},{"key":"r028","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041429"},{"key":"r029","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3076-3087.2003"},{"key":"r030","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092140"},{"key":"r031","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092618"},{"key":"r032","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100348"},{"key":"r033","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100223"},{"key":"r034","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.8.080706.092315"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1100066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T13:30:46Z","timestamp":1592487046000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJMoa1100066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,14]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,7,14]]}},"alternative-id":["10.1056\/NEJMoa1100066"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1100066","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.10494957.11335055","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,14]]}}}