{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:30:19Z","timestamp":1791469819113,"version":"4.3.4"},"reference-count":35,"publisher":"Massachusetts Medical Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2012,3,8]]},"DOI":"10.1056\/nejmoa1106173","type":"journal-article","created":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T17:02:33Z","timestamp":1331139753000},"page":"904-913","source":"Crossref","is-referenced-by-count":509,"title":["Enzyme-Replacement Therapy in Life-Threatening Hypophosphatasia"],"prefix":"10.1056","volume":"366","author":[{"given":"Michael P.","family":"Whyte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl R.","family":"Greenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada J.","family":"Salman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Bober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"McAlister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Wenkert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Van Sickle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill H.","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence S.","family":"Edgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin L.","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Hamdan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Bishop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mairead","family":"McGinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean N.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Cleveland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Cranley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom D.","family":"Thacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill E.","family":"Mayhew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Downs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Mill\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison M.","family":"Skrinar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Crine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hal","family":"Landy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(65)91422-4"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1038\/212901a0"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112031"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113440"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.01.020"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(57)90124-9"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.20.7666"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2001.3283"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.454"},{"key":"r013","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1001\/archpedi.1948.02030020840003","volume":"75","author":"Rathbun JC","year":"1948","journal-title":"Am J Dis Child"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80061-9"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80079-7"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.4.624"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2131"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-008-0708-3"},{"key":"r019","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508401110"},{"key":"r020","unstructured":"Ish-Shalom S, Budden F, Fraser D, et al. A follow-up of hypophosphatasia from infancy to adulthood. Presented at the 8th Annual Scientific Meeting of the American Society for Bone and Mineral Research, Anaheim, CA, June 21\u201324, 1986."},{"key":"r021","first-page":"S155","volume":"7","author":"Whyte MP","year":"1992","journal-title":"J Bone Miner Res"},{"key":"r022","first-page":"1555","volume":"151","author":"Anderson HC","year":"1997","journal-title":"Am J Pathol"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.071213"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1999.14.12.2015"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.03.770"},{"key":"r027","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510393517"},{"key":"r028","unstructured":"Greenberg CR, Kishnani P, Landy H, et al. Hypophosphatasia: enzyme replacement with ENB-0040, a bone-targeted human recombinant tissue nonspecific alkaline phosphatase (TNSALP) fusion protein. Presented at the 16th Annual Clinical Genetics Meeting of the American College of Medical Genetics, Tampa, FL, March 25\u201329, 2009."},{"key":"r029","unstructured":"Beal SL, Sheiner LB, NONMEM Project Group. NONMEM users guide, part I. San Francisco: University of California, San Francisco, 1989."},{"key":"r031","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/26.4.404"},{"key":"r032","doi-asserted-by":"publisher","DOI":"10.2307\/3001968"},{"key":"r033","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/46.3.132"},{"key":"r034","doi-asserted-by":"publisher","DOI":"10.1038\/ng1221"},{"key":"r035","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1902"},{"key":"r036","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.1.130"},{"key":"r037","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6513.79"},{"key":"r038","unstructured":"Fleisch H. Bisphosphonates in bone disease. 2nd ed. New York: Parthenon, 1995:149-50."},{"key":"r039","first-page":"S483","volume":"15","author":"Whyte MP","year":"2000","journal-title":"J Bone Miner Res"},{"key":"r040","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1276205"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1106173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T11:20:45Z","timestamp":1497957645000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJMoa1106173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,8]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,3,8]]}},"alternative-id":["10.1056\/NEJMoa1106173"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1106173","relation":{},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,8]]}}}