{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:38:54Z","timestamp":1792427934673,"version":"4.5.0"},"reference-count":39,"publisher":"Massachusetts Medical Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2014,1,30]]},"DOI":"10.1056\/nejmoa1114576","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T17:40:16Z","timestamp":1387388416000},"page":"433-443","source":"Crossref","is-referenced-by-count":416,"title":["Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis"],"prefix":"10.1056","volume":"370","author":[{"given":"Lenny","family":"van Bon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alsya J.","family":"Affandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Broen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romy B.","family":"Christmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renoud J.","family":"Marijnissen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Stawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina A.","family":"Farina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Stifano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison L.","family":"Mathes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Cossu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"York","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Wenink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Huijbens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Hesselstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tore","family":"Saxne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"DiMarzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Wuttge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep K.","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Reveille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shervin","family":"Assassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Mayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost P.H.","family":"Drenth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"de Graaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"den Heijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cees G.M.","family":"Kallenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bijl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnoud","family":"Loof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim B.","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo A.B.","family":"Joosten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip","family":"de Keyser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaella","family":"Scorza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Lunardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piet L.C.M.","family":"van Riel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madelon","family":"Vonk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waander","family":"van Heerde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Meller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Homey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Beretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Roest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Trojanowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lafyatis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy R.D.J.","family":"Radstake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0806188"},{"key":"r002","first-page":"202","volume":"15","author":"LeRoy EC","year":"1988","journal-title":"J Rheumatol"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1084\/jem.135.6.1351"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32832fd69e"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2007.10.010"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1002\/art.24958"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp119"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1038\/ng.565"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1002\/art.24183"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1002\/art.22382"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1177\/0961203308090020"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0510837103"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.063412"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.121400"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1002\/art.23486"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0084"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780251101"},{"key":"r019","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780400928"},{"key":"r020","first-page":"2225","volume":"24","author":"van der Heijde D","year":"1997","journal-title":"J Rheumatol"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1007\/s002960050098"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-94-4-482"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1002\/art.21257"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem313"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.132464"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00254.2009"},{"key":"r027","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1182\/blood.V90.3.909","volume":"90","author":"Rollins BJ","year":"1997","journal-title":"Blood"},{"key":"r028","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002657"},{"key":"r029","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.09.035"},{"key":"r030","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.5.2680"},{"key":"r031","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005981"},{"key":"r032","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1160\/TH03-02-0069","volume":"90","author":"Pitsilos S","year":"2003","journal-title":"Thromb Haemost"},{"key":"r033","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23435"},{"key":"r034","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090593"},{"key":"r035","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63685-1"},{"key":"r036","doi-asserted-by":"publisher","DOI":"10.1002\/art.27220"},{"key":"r037","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.022970"},{"key":"r038","doi-asserted-by":"publisher","DOI":"10.1186\/ar295"},{"key":"r039","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-010-1610-4"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1114576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T08:49:19Z","timestamp":1597222159000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1114576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,30]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,1,30]]}},"alternative-id":["10.1056\/NEJMoa1114576"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1114576","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718213551.793489635","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718213551.793516637","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718213551.793489275","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,30]]}}}