{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:31:26Z","timestamp":1792099886332,"version":"4.4.0"},"reference-count":40,"publisher":"Massachusetts Medical Society","issue":"25","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2012,12,20]]},"DOI":"10.1056\/nejmoa1205099","type":"journal-article","created":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T20:17:30Z","timestamp":1355948250000},"page":"2396-2406","source":"Crossref","is-referenced-by-count":640,"title":["Two Randomized Trials of Canakinumab in Systemic Juvenile Idiopathic Arthritis"],"prefix":"10.1056","volume":"367","author":[{"given":"Nicolino","family":"Ruperto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermine I.","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Quartier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"Constantin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Wulffraat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Horneff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riva","family":"Brik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liza","family":"McCann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozgur","family":"Kasapcopur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Rutkowska-Sak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayfel","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yackov","family":"Berkun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muferet","family":"Erguven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Goffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilmann","family":"Kallinich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila K.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosef","family":"Uziel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Viola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Nistala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Cimaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel A.","family":"Ferrandiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit","family":"Flato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luz","family":"Gamir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Kone-Paut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei","family":"Grom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seza","family":"Ozen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Sztajnbok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Lheritier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Abrams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Martini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Lovell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60244-4"},{"key":"r002","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60363-8"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91710-8"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.12.1428"},{"key":"r005","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119207"},{"key":"r006","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.12.016"},{"key":"r008","first-page":"203","volume":"25","author":"De Benedetti F","year":"1998","journal-title":"J Rheumatol"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60454-7"},{"key":"r010","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1056\/NEJMoa1112802","volume":"367","author":"De Benedetti F","year":"2012","journal-title":"N Engl J Med"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050473"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1002\/art.23437"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.134254"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1002\/art.30128"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810787"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1186\/ar3266"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1002\/art.23475"},{"key":"r018","doi-asserted-by":"publisher","DOI":"10.1002\/art.33342"},{"key":"r019","first-page":"390","volume":"31","author":"Petty RE","year":"2004","journal-title":"J Rheumatol"},{"key":"r020","first-page":"1991","volume":"25","author":"Petty RE","year":"1998","journal-title":"J Rheumatol"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780290216"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.188946"},{"key":"r023","doi-asserted-by":"publisher","DOI":"10.1002\/art.27670"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199707)40:7<1202::AID-ART3>3.0.CO;2-R"},{"key":"r025","first-page":"919","volume":"23","author":"Giannini EH","year":"1996","journal-title":"J Rheumatol"},{"key":"r026","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780371209"},{"key":"r027","first-page":"S1","volume":"19","author":"Paediatric Rheumatology International Trials Organisation (PRINTO)","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"r028","first-page":"S1","volume":"19","author":"Ruperto N","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"r029","first-page":"1058","volume":"29","author":"Brunner HI","year":"2002","journal-title":"J Rheumatol"},{"key":"r030","first-page":"2290","volume":"31","author":"Wallace CA","year":"2004","journal-title":"J Rheumatol"},{"key":"r031","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20497"},{"key":"r032","doi-asserted-by":"publisher","DOI":"10.1002\/art.24534"},{"key":"r033","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60998-8"},{"key":"r034","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60413-8"},{"key":"r035","doi-asserted-by":"publisher","DOI":"10.1002\/art.30105"},{"key":"r036","doi-asserted-by":"publisher","DOI":"10.1002\/art.24174"},{"key":"r037","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.02.040"},{"key":"r038","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341216"},{"key":"r040","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/art.27218","volume":"62","author":"Hashkes PJ","year":"2010","journal-title":"Arthritis Rheum"},{"key":"r041","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc081987"},{"key":"r042","first-page":"2496","volume":"359","author":"De Vries MK","year":"2008","journal-title":"N Engl J Med"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1205099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T13:41:37Z","timestamp":1714743697000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/abs\/10.1056\/NEJMoa1205099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,20]]},"references-count":40,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2012,12,20]]}},"alternative-id":["10.1056\/NEJMoa1205099"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1205099","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717968744.793491946","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717968744.793533221","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,20]]}}}