{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:47:58Z","timestamp":1792090078482,"version":"4.4.0"},"reference-count":24,"publisher":"Massachusetts Medical Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["N Engl J Med"],"published-print":{"date-parts":[[2014,7,31]]},"DOI":"10.1056\/nejmoa1405095","type":"journal-article","created":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T09:00:12Z","timestamp":1401613212000},"page":"424-433","source":"Crossref","is-referenced-by-count":2629,"title":["Enzalutamide in Metastatic Prostate Cancer before Chemotherapy"],"prefix":"10.1056","volume":"371","author":[{"given":"Tomasz M.","family":"Beer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana E.","family":"Rathkopf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohann","family":"Loriot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora N.","family":"Sternberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestia S.","family":"Higano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Iversen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suman","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Carles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Chowdhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian D.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann S.","family":"de Bono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Fizazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"Joshua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choung-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Go","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Mainwaring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Mansbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah B.","family":"Noonberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Perabo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De","family":"Phung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Saad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard I.","family":"Scher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary-Ellen","family":"Taplin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"Venner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Tombal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"150","reference":[{"key":"r001","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"r002","first-page":"293","volume":"1","author":"Huggins C","year":"1941","journal-title":"Cancer Res"},{"key":"r003","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707313370502"},{"key":"r004","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70700-8"},{"key":"r005","first-page":"CD003506","volume":"1","author":"Nair B","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"r007","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1207506"},{"key":"r008","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209096"},{"key":"r009","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014618"},{"key":"r010","doi-asserted-by":"publisher","DOI":"10.1038\/nm972"},{"key":"r011","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-2660"},{"key":"r012","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0249"},{"key":"r013","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0943"},{"key":"r014","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2815"},{"key":"r015","doi-asserted-by":"publisher","DOI":"10.1126\/science.1168175"},{"key":"r016","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60172-9"},{"key":"r017","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.4487"},{"key":"r018","first-page":"65","volume":"6","author":"Holm S","year":"1979","journal-title":"Scand J Stat"},{"key":"r019","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001294"},{"key":"r020","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040720"},{"key":"r021","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61389-X"},{"key":"r022","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2011.04.014"},{"key":"r023","first-page":"233","volume":"3","author":"Engel-Nitz NM","year":"2011","journal-title":"Cancer Manag Res"},{"key":"r024","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.770164"},{"key":"r025","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1213755"}],"container-title":["New England Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nejm.org\/doi\/pdf\/10.1056\/NEJMoa1405095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T18:11:59Z","timestamp":1494267119000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.nejm.org\/doi\/10.1056\/NEJMoa1405095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,31]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,7,31]]}},"alternative-id":["10.1056\/NEJMoa1405095"],"URL":"https:\/\/doi.org\/10.1056\/nejmoa1405095","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718429957.793514271","asserted-by":"object"}]},"ISSN":["0028-4793","1533-4406"],"issn-type":[{"value":"0028-4793","type":"print"},{"value":"1533-4406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,31]]}}}